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The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
Manry, J.; Bastard, P.; Gervais, A.; Le Voyer, T.; Rosain, J.; Philippot, Q.; Michailidis, E.; Hoffmann, H. H.; Eto, S.; Garcia-Prat, M.; Bizien, L.; Parra-Martinez, A.; Yang, R.; Haljasmagi, L.; Migaud, M.; Sarekannu, K.; Maslovskaja, J.; de Prost, N.; Tandjaoui-Lambiotte, Y.; Luyt, C. E.; Amador-Borrero, B.; Gaudet, A.; Poissy, J.; Morel, P.; Richard, P.; Cognasse, F.; Troya, J.; Trouillet-Assant, S.; Belot, A.; Saker, K.; Garcon, P.; Riviere, J. G.; Lagier, J. C.; Gentile, S.; Rosen, L. B.; Shaw, E.; Morio, T.; Tanaka, J.; Dalmau, D.; Tharaux, P. L.; Sene, D.; Stepanian, A.; Megarbane, B.; Triantafyllia, V.; Fekkar, A.; Heath, J. R.; Franco, J. L.; Anaya, J. M.; Sole-Violan, J.; Imberti, L.; Biondi, A.; Bonfanti, P.; Castagnoli, R.; Delmonte, O. M.; Zhang, Y.; Snow, A. L.; Holland, S. M.; Biggs, C. M.; Moncada-Velez, M.; Arias, A. A.; Lorenzo, L.; Boucherit, S.; Anglicheau, D.; Planas, A. M.; Haerynck, F.; Duvlis, S.; Ozcelik, T.; Keles, S.; Bousfiha, A. A.; El Bakkouri, J.; Ramirez-Santana, C.; Paul, S.; Pan-Hammarstrom, Q.; Hammarstrom, L.; Dupont, A.; Kurolap, A.; Metz, C. N.; Aiuti, A.; Casari, G.; Lampasona, V.; Ciceri, F.; Barreiros, L. A.; Dominguez-Garrido, E.; Vidigal, M.; Zatz, M.; van de Beek, D.; Sahanic, S.; Tancevski, I.; Stepanovskyy, Y.; Boyarchuk, O.; Nukui, Y.; Tsumura, M.; Vidaur, L.; Tangye, S. G.; Burrel, S.; Duffy, D.; Quintana-Murci, L.; Klocperk, A.; Kann, N. Y.; Shcherbina, A.; Lau, Y. L.; Leung, D.; Coulongeat, M.; Marlet, J.; Koning, R.; Reyes, L. F.; Chauvineau-Grenier, A.; Venet, F.; Monneret, G.; Nussenzweig, M. C.; Arrestier, R.; Boudhabhay, I.; Baris-Feldman, H.; Hagin, D.; Wauters, J.; Meyts, I.; Dyer, A. H.; Kennelly, S. P.; Bourke, N. M.; Halwani, R.; Sharif-Askari, F. S.; Dorgham, K.; Sallette, J.; Sedkaoui, S. M.; AlKhater, S.; Rigo-Bonnin, R.; Morandeira, F.; Roussel, L.; Vinh, D. C.; Erikstrup, C.; Condino-Neto, A.; Prando, C.; Bondarenko, A.; Spaan, A. N.; Gilardin, L.; Fellay, J.; Lyonnet, S.; Bilguvar, K.; Lifton, R. P.; Mane, S.; Lab, Hgid; Clinicians, Covid; Clinicians, Covid-Storm; Group, Niaid Immune Response to COVID; Group, Nh-Covair Study; Danish, Chge; Danish Blood Donor, Study; St. James's Hospital, Sars CoV Interest Group; French, Covid Cohort Study Group; Imagine, Covid-Group; Milieu Interieur, Consortium; Co, V. Contact Cohort; Amsterdam, U. M. C. Covid-Biobank Investigators; Effort, Covid Human Genetic; Group, Cp-Covid-; cohort, Constances; Study, C. Dijon; Cerba, Health-Care; Etablissement Francais du Sang Study, group; Anderson, M. S.; Boisson, B.; Beziat, V.; Zhang, S. Y.; Andreakos, E.; Hermine, O.; Pujol, A.; Peterson, P.; Mogensen, T. H.; Rowen, L.; Mond, J.; Debette, S.; de Lamballerie, X.; Burdet, C.; Bouadma, L.; Zins, M.; Soler-Palacin, P.; Colobran, R.; Gorochov, G.; Solanich, X.; Susen, S.; Martinez-Picado, J.; Raoult, D.; Vasse, M.; Gregersen, P. K.; Piemonti, L.; Rodriguez-Gallego, C.; Notarangelo, L. D.; Su, H. C.; Kisand, K.; Okada, S.; Puel, A.; Jouanguy, E.; Rice, C. M.; Tiberghien, P.; Zhang, Q.; Casanova, J. L.; Abel, L.; Cobat, A.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 119 (21) :e2200413119, 2022 10.1073/pnas.2200413119
Severe COVID-19 represents an undiagnosed primary immunodeficiency in a high proportion of infected individuals
Gray, P. E.; Bartlett, A. W.; Tangye, S. G.
Clinical & Translational Immunology 11 (4) :e1365, 2022 10.1002/cti2.1365
Coronavirus disease 2019 in patients with inborn errors of immunity: lessons learned
Bucciol, G.; Tangye, S. G.; Meyts, I.
CURRENT OPINION IN PEDIATRICS 33 (6) :648-656, 2021 10.1097/MOP.0000000000001062
Mechanisms underlying host defense and disease pathology in response to severe acute respiratory syndrome (SARS)-CoV2 infection: insights from inborn errors of immunity
Tangye, S.; Bucciol, G.; Meyts, I.
Current Opinion in Allergy and Clinical Immunology 21 (6) :515-524, 2021 10.1097/ACI.0000000000000786
Intrinsic Defects in B Cell Development and Differentiation, T Cell Exhaustion and Altered Unconventional T Cell Generation Characterize Human Adenosine Deaminase Type 2 Deficiency
Yap, J. Y.; Moens, L.; Lin, M. W.; Kane, A.; Kelleher, A.; Toong, C.; Wu, K. H. C.; Sewell, W. A.; Phan, T. G.; Hollway, G. E.; Enthoven, K.; Gray, P. E.; Casas-Martin, J.; Wouters, C.; De Somer, L.; Hershfield, M.; Bucciol, G.; Delafontaine, S.; Ma, C. S.; Tangye, S. G.; Meyts, I.
JOURNAL OF CLINICAL IMMUNOLOGY 41 (8) :1915-1935, 2021 10.1007/s10875-021-01141-0
Molecular regulation and dysregulation of T follicular helper cells - learning from inborn errors of immunity
Tangye, S. G.; Ma, C. S.
CURRENT OPINION IN IMMUNOLOGY 72 :249-261, 2021 10.1016/j.coi.2021.06.011
The expansion of human T-bet(high)CD21(low) B cells is T cell dependent
Keller, B.; Strohmeier, V.; Harder, I.; Unger, S.; Payne, K. J.; Andrieux, G.; Boerries, M.; Felixberger, P. T.; Landry, J. J. M.; Nieters, A.; Rensing-Ehl, A.; Salzer, U.; Frede, N.; Usadel, S.; Elling, R.; Speckmann, C.; Hainmann, I.; Ralph, E.; Gilmour, K.; Wentink, M. W. J.; van der Burg, M.; Kuehn, H. S.; Rosenzweig, S. D.; Kolsch, U.; von Bernuth, H.; Kaiser-Labusch, P.; Gothe, F.; Hambleton, S.; Vlagea, A. D.; Garcia Garcia, A.; Alsina, L.; Markelj, G.; Avcin, T.; Vasconcelos, J.; Guedes, M.; Ding, J. Y.; Ku, C. L.; Shadur, B.; Avery, D. T.; Venhoff, N.; Thiel, J.; Becker, H.; Erazo-Borras, L.; Trujillo-Vargas, C. M.; Franco, J. L.; Fieschi, C.; Okada, S.; Gray, P. E.; Uzel, G.; Casanova, J. L.; Fliegauf, M.; Grimbacher, B.; Eibel, H.; Ehl, S.; Voll, R. E.; Rizzi, M.; Stepensky, P.; Benes, V.; Ma, C. S.; Bossen, C.; Tangye, S. G.; Warnatz, K.
Science Immunology 6 (64) :eabh0891, 2021 10.1126/sciimmunol.abh0891
Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child
Ogishi, M.; Yang, R.; Aytekin, C.; Langlais, D.; Bourgey, M.; Khan, T.; Ali, F. A.; Rahman, M.; Delmonte, O. M.; Chrabieh, M.; Zhang, P.; Gruber, C.; Pelham, S. J.; Spaan, A. N.; Rosain, J.; Lei, W. T.; Drutman, S.; Hellmann, M. D.; Callahan, M. K.; Adamow, M.; Wong, P.; Wolchok, J. D.; Rao, G.; Ma, C. S.; Nakajima, Y.; Yaguchi, T.; Chamoto, K.; Williams, S. C.; Emile, J. F.; Rozenberg, F.; Glickman, M. S.; Rapaport, F.; Kerner, G.; Allington, G.; Tezcan, I.; Cagdas, D.; Hosnut, F. O.; Dogu, F.; Ikinciogullari, A.; Rao, V. K.; Kainulainen, L.; Beziat, V.; Bustamante, J.; Vilarinho, S.; Lifton, R. P.; Boisson, B.; Abel, L.; Bogunovic, D.; Marr, N.; Notarangelo, L. D.; Tangye, S. G.; Honjo, T.; Gros, P.; Boisson-Dupuis, S.; Casanova, J. L.
NATURE MEDICINE 27 (9) :1646-1654, 2021 10.1038/s41591-021-01388-5
Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents
Levy, R.; Langlais, D.; Beziat, V.; Rapaport, F.; Rao, G.; Lazarov, T.; Bourgey, M.; Zhou, Y. J.; Briand, C.; Moriya, K.; Ailal, F.; Avery, D. T.; Markle, J.; Lim, A. I.; Ogishi, M.; Yang, R.; Pelham, S.; Emam, M.; Migaud, M.; Deswarte, C.; Habib, T.; Saraiva, L. R.; Moussa, E. A.; Guennoun, A.; Boisson, B.; Belkaya, S.; Martinez-Barricarte, R.; Rosain, J.; Belkadi, A.; Breton, S.; Payne, K.; Benhsaien, I.; Plebani, A.; Lougaris, V.; Di Santo, J. P.; Neven, B.; Abel, L.; Ma, C. S.; Bousfiha, A. A.; Marr, N.; Bustamante, J.; Liu, K.; Gros, P.; Geissmann, F.; Tangye, S. G.; Casanova, J. L.; Puel, A.
JOURNAL OF CLINICAL INVESTIGATION 131 (17) :e150143, 2021 10.1172/JCI150143
Tissue-resident regulatory T cells accumulate at human barrier lymphoid organs
Hewavisenti, R. V. Ferguson, A. L. Gasparini, G. Ohashi, T. Braun, A. Watkins, T. S. Miles, J. J. Elliott, M. Sierro, F. Feng, C. G. Britton, W. J. Gebhardt, T. Tangye, S. Palendira, U.
IMMUNOLOGY AND CELL BIOLOGY 2021 10.1111/imcb.12481
CD4(+) T cells that help B cells - a proposal for uniform nomenclature
Eisenbarth, S. C.; Baumjohann, D.; Craft, J.; Fazilleau, N.; Ma, C. S.; Tangye, S. G.; Vinuesa, C. G.; Linterman, M. A.
TRENDS IN IMMUNOLOGY 42 (8) :658-669, 2021 10.1016/j.it.2021.06.003
Hematopoietic Stem Cell Transplantation Cures Chronic Aichi Virus Infection in a Patient with X-linked Agammaglobulinemia
Bucciol, G.; Tousseyn, T.; Jansen, K.; Casteels, I.; Tangye, S. G.; Breuer, J.; Brown, J. R.; Wollants, E.; Van Ranst, M.; Moens, L.; Mekahli, D.; Meyts, I.
JOURNAL OF CLINICAL IMMUNOLOGY 41 (6) :1403-1405, 2021 10.1007/s10875-021-01056-w
Phosphatidylinositol 3-kinase signaling and immune regulation: insights into disease pathogenesis and clinical implications
Nguyen, T.; Deenick, E. K.; Tangye, S. G.
Expert Review of Clinical Immunology 17 (8) :905-914, 2021 10.1080/1744666X.2021.1945443
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Bastard, P.; Gervais, A.; Le Voyer, T.; Rosain, J.; Philippot, Q.; Manry, J.; Michailidis, E.; Hoffmann, H. H.; Eto, S.; Garcia-Prat, M.; Bizien, L.; Parra-Martinez, A.; Yang, R.; Haljasmagi, L.; Migaud, M.; Sarekannu, K.; Maslovskaja, J.; de Prost, N.; Tandjaoui-Lambiotte, Y.; Luyt, C. E.; Amador-Borrero, B.; Gaudet, A.; Poissy, J.; Morel, P.; Richard, P.; Cognasse, F.; Troya, J.; Trouillet-Assant, S.; Belot, A.; Saker, K.; Garcon, P.; Riviere, J. G.; Lagier, J. C.; Gentile, S.; Rosen, L. B.; Shaw, E.; Morio, T.; Tanaka, J.; Dalmau, D.; Tharaux, P. L.; Sene, D.; Stepanian, A.; Megarbane, B.; Triantafyllia, V.; Fekkar, A.; Heath, J. R.; Franco, J. L.; Anaya, J. M.; Sole-Violan, J.; Imberti, L.; Biondi, A.; Bonfanti, P.; Castagnoli, R.; Delmonte, O. M.; Zhang, Y.; Snow, A. L.; Holland, S. M.; Biggs, C.; Moncada-Velez, M.; Arias, A. A.; Lorenzo, L.; Boucherit, S.; Coulibaly, B.; Anglicheau, D.; Planas, A. M.; Haerynck, F.; Duvlis, S.; Nussbaum, R. L.; Ozcelik, T.; Keles, S.; Bousfiha, A. A.; El Bakkouri, J.; Ramirez-Santana, C.; Paul, S.; Pan-Hammarstrom, Q.; Hammarstrom, L.; Dupont, A.; Kurolap, A.; Metz, C. N.; Aiuti, A.; Casari, G.; Lampasona, V.; Ciceri, F.; Barreiros, L. A.; Dominguez-Garrido, E.; Vidigal, M.; Zatz, M.; van de Beek, D.; Sahanic, S.; Tancevski, I.; Stepanovskyy, Y.; Boyarchuk, O.; Nukui, Y.; Tsumura, M.; Vidaur, L.; Tangye, S. G.; Burrel, S.; Duffy, D.; Quintana-Murci, L.; Klocperk, A.; Kann, N. Y.; Shcherbina, A.; Lau, Y. L.; Leung, D.; Coulongeat, M.; Marlet, J.; Koning, R.; Reyes, L. F.; Chauvineau-Grenier, A.; Venet, F.; Monneret, G.; Nussenzweig, M. C.; Arrestier, R.; Boudhabhay, I.; Baris-Feldman, H.; Hagin, D.; Wauters, J.; Meyts, I.; Dyer, A. H.; Kennelly, S. P.; Bourke, N. M.; Halwani, R.; Sharif-Askari, N. S.; Dorgham, K.; Sallette, J.; Sedkaoui, S. M.; AlKhater, S.; Rigo-Bonnin, R.; Morandeira, F.; Roussel, L.; Vinh, D. C.; Ostrowski, S. R.; Condino-Neto, A.; Prando, C.; Bonradenko, A.; Spaan, A. N.; Gilardin, L.; Fellay, J.; Lyonnet, S.; Bilguvar, K.; Lifton, R. P.; Mane, S.; Lab, Hgid; Clinicians, Covid; Clinicians, Covid-Storm; Group, Niaid Immune Response to COVID; Group, Nh-Covair Study; Danish, Chge; Danish Blood Donor, Study; St. James's, Hospital; group, Sars CoV2 Interest; French, Covid Cohort Study Group; Imagine, Covid-Group; Milieu Interieur, Consortium; Co, V. Contact Cohort; Amsterdam, U. M. C. Covid; Biobank, Investigators; Effort, Covid Human Genetic; cohort, Constances; Study, C. Dijon; Cerba, Health-Care; Etablissement du Sang study, group; Anderson, M. S.; Boisson, B.; Beziat, V.; Zhang, S. Y.; Vandreakos, E.; Hermine, O.; Pujol, A.; Peterson, P.; Mogensen, T. H.; Rowen, L.; Mond, J.; Debette, S.; de Lamballerie, X.; Duval, X.; Mentre, F.; Zins, M.; Soler-Palacin, P.; Colobran, R.; Gorochov, G.; Solanich, X.; Susen, S.; Martinez-Picado, J.; Raoult, D.; Vasse, M.; Gregersen, P. K.; Piemonti, L.; Rodriguez-Gallego, C.; Notarangelo, L. D.; Su, H. C.; Kisand, K.; Okada, S.; Puel, A.; Jouanguy, E.; Rice, C. M.; Tiberghien, P.; Zhang, Q.; Cobat, A.; Abel, L.; Casanova, J. L.
Science Immunology 6 (62) :eabl4340, 2021 10.1126/sciimmunol.abl4340
Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance
Asano, T.; Khourieh, J.; Zhang, P.; Rapaport, F.; Spaan, A. N.; Li, J.; Lei, W. T.; Pelham, S. J.; Hum, D.; Chrabieh, M.; Han, J. E.; Guerin, A.; Mackie, J.; Gupta, S.; Saikia, B.; Baghdadi, J. E. I.; Fadil, I.; Bousfiha, A.; Habib, T.; Marr, N.; Ganeshanandan, L.; Peake, J.; Droney, L.; Williams, A.; Celmeli, F.; Hatipoglu, N.; Ozcelik, T.; Picard, C.; Abel, L.; Tangye, S. G.; Boisson-Dupuis, S.; Zhang, Q.; Puel, A.; Beziat, V.; Casanova, J. L.; Boisson, B.
JOURNAL OF EXPERIMENTAL MEDICINE 218 (8) :e20202592, 2021 10.1084/jem.20202592
Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency
Cagdas, D. Mayr, D. Baris, S. Worley, L. Langley, D. B. Metin, A. Aytekin, E. S. Atan, R. Kasap, N. Bal, S. K. Dmytrus, J. Heredia, R. J. Karasu, G. Torun, S. H. Toyran, M. Karakoc-Aydiner, E. Christ, D. Kuskonmaz, B. Uckan-Cetinkaya, D. Uner, A. Oberndorfer, F. Schiefer, A. I. Uzel, G. Deenick, E. K. Keller, B. Warnatz, K. Neven, B. Durandy, A. Sanal, O. Ma, C. S. Ozen, A. Stepensky, P. Tezcan, I. Boztug, K. Tangye, S. G.
JOURNAL OF CLINICAL IMMUNOLOGY 2021 10.1007/s10875-021-01031-5