Garvan Institute of Medical Research

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Zammit, N. W.; Siggs, O. M.; Gray, P. E.; Horikawa, K.; Langley, D. B.; Walters, S. N.; Daley, S. R.; Loetsch, C.; Warren, J.; Yap, J. Y.; Cultrone, D.; Russell, A.; Malle, E. K.; Villanueva, J. E.; Cowley, M. J.; Gayevskiy, V.; Dinger, M. E.; Brink, R.; Zahra, D.; Chaudhri, G.; Karupiah, G.; Whittle, B.; Roots, C.; Bertram, E.; Yamada, M.; Jeelall, Y.; Enders, A.; Clifton, B. E.; Mabbitt, P. D.; Jackson, C. J.; Watson, S. R.; Jenne, C. N.; Lanier, L. L.; Wiltshire, T.; Spitzer, M. H.; Nolan, G. P.; Schmitz, F.; Aderem, A.; Porebski, B. T.; Buckle, A. M.; Abbott, D. W.; Ziegler, J. B.; Craig, M. E.; Benitez-Aguirre, P.; Teo, J.; Tangye, S. G.; King, C.; Wong, M.; Cox, M. P.; Phung, W.; Tang, J.; Sandoval, W.; Wertz, I. E.; Christ, D.; Goodnow, C. C.; Grey, S. T.

NATURE IMMUNOLOGY 20 (10) :1299-1310, 2019 10.1038/s41590-019-0492-0

Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4(+) T cells

Bier, J.; Rao, G.; Payne, K.; Brigden, H.; French, E.; Pelham, S. J.; Lau, A.; Lenthall, H.; Edwards, E. S. J.; Smart, J. M.; Cole, T. S.; Choo, S.; Joshi, A. Y.; Abraham, R. S.; O'Sullivan, M.; Boztug, K.; Meyts, I.; Gray, P. E.; Berglund, L. J.; Hsu, P.; Wong, M.; Holland, S. M.; Notarangelo, L. D.; Uzel, G.; Ma, C. S.; Brink, R.; Tangye, S. G.; Deenick, E. K.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 144 (1) :236-253, 2019 10.1016/j.jaci.2019.01.033

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects

Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010

B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans

Moran, I.; Avery, D. T.; Payne, K.; Lenthall, H.; Davies, E. G.; Burns, S.; Ip, W.; Oleastro, M. M.; Reisli, I.; Guner, S.; Keles, S.; Notarangelo, L.; Deenick, E. K.; Goodnow, C. C.; Zahra, D.; Brink, R.; Circa; Wong, M.; Tangye, S. G.; Ma, C. S.; Phan, T. G.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 143 (6) :2302-2305, 2019 10.1016/j.jaci.2019.02.010

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

Moran, I.; Nguyen, A.; Khoo, W. H.; Butt, D.; Bourne, K.; Young, C.; Hermes, J. R.; Biro, M.; Gracie, G.; Ma, C. S.; Munier, C. M. L.; Luciani, F.; Zaunders, J.; Parker, A.; Kelleher, A. D.; Tangye, S. G.; Croucher, P. I.; Brink, R.; Read, M. N.; Phan, T. G.

Nature Communications 9 (1) :3372, 2018 10.1038/s41467-018-05772-7

Germline-activating mutations in PIK3CD compromise B cell development and function

Avery, D. T.; Kane, A.; Nguyen, T.; Lau, A.; Nguyen, A.; Lenthall, H.; Payne, K.; Shi, W.; Brigden, H.; French, E.; Bier, J.; Hermes, J. R.; Zahra, D.; Sewell, W. A.; Butt, D.; Elliott, M.; Boztug, K.; Meyts, I.; Choo, S.; Hsu, P.; Wong, M.; Berglund, L. J.; Gray, P.; O'Sullivan, M.; Cole, T.; Holland, S. M.; Ma, C. S.; Burkhart, C.; Corcoran, L. M.; Phan, T. G.; Brink, R.; Uzel, G.; Deenick, E. K.; Tangye, S. G.

JOURNAL OF EXPERIMENTAL MEDICINE 215 (8) :2073-2095, 2018 10.1084/jem.20180010

Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice

Byrne, F. L.; Olzomer, E. M.; Brink, R.; Hoehn, K. L.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 315 (2) :E286-E293, 2018 10.1152/ajpendo.00082.2018

SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation

Thientosapol, E. S.; Bosnjak, D.; Durack, T.; Stevanovski, I.; van Geldermalsen, M.; Holst, J.; Jahan, Z.; Shepard, C.; Weninger, W.; Kim, B.; Brink, R.; Jolly, C. J.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115 (19) :4921-4926, 2018 10.1073/pnas.1719771115

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination

Burnett, D. L.; Langley, D. B.; Schofield, P.; Hermes, J. R.; Chan, T. D.; Jackson, J.; Bourne, K.; Reed, J. H.; Patterson, K.; Porebski, B. T.; Brink, R.; Christ, D.; Goodnow, C. C.

SCIENCE 360 (6385) :223-226, 2018 10.1126/science.aao3859

Self-Reactive B Cells in the Germinal Center Reaction

Brink, R.; Phan, T. G.

Annual Review of Immunology 36 :339-357, 2018 10.1146/annurev-immunol-051116-052510

Atypical chemokine receptor 4 shapes activated B cell fate

Kara, E. E.; Bastow, C. R.; McKenzie, D. R.; Gregor, C. E.; Fenix, K. A.; Babb, R.; Norton, T. S.; Zotos, D.; Rodda, L. B.; Hermes, J. R.; Bourne, K.; Gilchrist, D. S.; Nibbs, R. J.; Alsharifi, M.; Vinuesa, C. G.; Tarlinton, D. M.; Brink, R.; Hill, G. R.; Cyster, J. G.; Comerford, I.; McColl, S. R.

JOURNAL OF EXPERIMENTAL MEDICINE 215 (3) :801-813, 2018 10.1084/jem.20171067

GPR65 inhibits experimental autoimmune encephalomyelitis through CD4(+) T cell independent mechanisms that include effects on iNKT cells

Wirasinha, R. C.; Vijayan, D.; Smith, N. J.; Parnell, G. P.; Swarbrick, A.; Brink, R.; King, C.; Stewart, G.; Booth, D. R.; Batten, M.

IMMUNOLOGY AND CELL BIOLOGY 96 (2) :128-136, 2018 10.1111/imcb.1031

CCR6 defines memory B cell precursors in mouse and human germinal centers revealing light zone location and predominant low antigen affinity.

Suan, D.; Krautler, N.J.; Maag, J.L.V.; Butt, D.; Bourne, K.; Hermes, J.R.; Avery, D.T.; Young, C.; Statham, A.; Elliott, M.; Dinger, M.E.; Basten, A.; Tangye, S.G.; Brink, R.

IMMUNITY 47 (6) :1142-1153, 2017 10.1016/j.immuni.2017.11.022

Structural basis of antigen recognition: crystal structure of duck egg lysozyme

Langley, D. B.; Crossett, B.; Schofield, P.; Jackson, J.; Zeraati, M.; Maltby, D.; Christie, M.; Burnett, D.; Brink, R.; Goodnow, C.; Christ, D.

Acta Crystallographica Section D-Structural Biology 73 (Pt 11) :910-920, 2017 10.1107/S2059798317013730