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61 items matching your search terms.
The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma
Parkin, A.; Man, J.; Chou, A.; Nagrial, A. M.; Samra, J.; Gill, A. J.; Timpson, P.; Pajic, M.
Diseases 6 (4) :103, 2018 10.3390/diseases6040103
Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors
Hoque, M.; Abbassi, R. H.; Froio, D.; Man, J.; Johns, T. G.; Stringer, B. W.; Day, B. W.; Pajic, M.; Kassiou, M.; Munoz, L.
PHARMACOLOGICAL RESEARCH 134 :166-178, 2018 10.1016/j.phrs.2018.06.023
Rho kinase inhibition blocks pancreatic ductal adenocarinoma invasion and tumor growth
Rath, N.; Munro, J.; Cutiongco, M. F.; Jagiello, A.; Gadegaard, N.; McGarry, L.; Unbekandt, M.; Michalopoulou, E.; Kamphorst, J. J.; Sumpton, D.; Mackay, G.; Vennin, C.; Pajic, M.; Timpson, P.; Olson, M. F.
CLINICAL CANCER RESEARCH 78 (12) :3321-3336, 2018 10.1158/0008-5472.Can-17-1339
OpenAccess publication Intravital imaging to monitor therapeutic response in moving hypoxic regions resistant to PI3K pathway targeting in pancreatic cancer
Conway, J. R. W.; Warren, S. C.; Herrmann, D.; Murphy, K. J.; Cazet, A. S.; Vennin, C.; Shearer, R. F.; Killen, M. J.; Magenau, A.; Melenec, P.; Pinese, M.; Nobis, M.; Zaratzian, A.; Boulghourjian, A.; Da Silva, A. M.; Del Monte-Nieto, G.; Adam, A. S. A.; Harvey, R. P.; Haigh, J. J.; Wang, Y.; Croucher, D. R.; Sansom, O. J.; Pajic, M.; Caldon, C. E.; Morton, J. P.; Timpson, P.
Cell Reports 23 (11) :3312-3326, 2018 10.1016/j.celrep.2018.05.038
Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth
Rath, N.; Munro, J.; Cutiongco, M. F.; Jagiello, A.; Gadegaard, N.; McGarry, L.; Unbekandt, M.; Michalopoulou, E.; Kamphorst, J. J.; Sumpton, D.; Mackay, G.; Vennin, C.; Pajic, M.; Timpson, P.; Olson, M. F.
CANCER RESEARCH 78 (12) :3321-3336, 2018 10.1158/0008-5472.CAN-17-1339
BRAF gene rearrangements can be identified by FISH studies in pancreatic acinar cell carcinoma
Chou, A.; Kim, Y.; Samra, J. S.; Pajic, M.; Gill, A. J.
PATHOLOGY 50 (3) :345-348, 2018 10.1016/j.pathol.2017.09.027
OpenAccess publication Reshaping the tumor stroma for treatment of pancreatic cancer
Vennin, C.; Murphy, K. J.; Morton, J. P.; Cox, T. R.; Pajic, M.; Timpson, P.
GASTROENTEROLOGY 154 (4) :820-838, 2018 10.1053/j.gastro.2017.11.280
OpenAccess publication 133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
Campbell, H.; Fleming, N.; Roth, I.; Mehta, S.; Wiles, A.; Williams, G.; Vennin, C.; Arsic, N.; Parkin, A.; Pajic, M.; Munro, F.; McNoe, L.; Black, M.; McCall, J.; Slatter, T. L.; Timpson, P.; Reddel, R.; Roux, P.; Print, C.; Baird, M. A.; Braithwaite, A. W.
Nature Communications 9 (1) :254, 2018 10.1038/s41467-017-02408-0
miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense
Pajic, M.; Froio, D.; Daly, S.; Doculara, L.; Millar, E.; Graham, P. H.; Drury, A.; Steinmann, A.; de Bock, C. E.; Boulghourjian, A.; Zaratzian, A.; Carroll, S.; Toohey, J.; O'Toole, S. A.; Harris, A. L.; Buffa, F. M.; Gee, H. E.; Hollway, G. E.; Molloy, T. J.
CANCER RESEARCH 78 (2) :501-515, 2018 10.1158/0008-5472.CAN-16-3105
OpenAccess publication Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology
Conway, J. R. W.; Vennin, C.; Cazet, A. S.; Herrmann, D.; Murphy, K. J.; Warren, S. C.; Wullkopf, L.; Boulghourjian, A.; Zaratzian, A.; Da Silva, A. M.; Pajic, M.; Morton, J. P.; Cox, T. R.; Timpson, P.
Scientific Reports 7 (1) :16887, 2017 10.1038/s41598-017-17177-5
Selected alkylating agents can overcome drug tolerance of G0-like tumor cells and eradicate BRCA1-deficient mammary tumors in mice
Pajic, M.; Blatter, S.; Guyader, C.; Gonggrijp, M.; Kersbergen, A.; Kucukosmanoglu, A.; Sol, W.; Drost, R.; Jonkers, J.; Borst, P.; Rottenberg, S.
CLINICAL CANCER RESEARCH 23 (22) :7020-7033, 2017 10.1158/1078-0432.CCR-17-1279
OpenAccess publication Transient targeting of the pancreatic cancer stroma as a 'fine-tuned' anti-tumor and anti-metastatic therapy
Vennin, C.; Cox, T. R.; Pajic, M.; Timpson, P.
Oncotarget 8 (49) :84635-84636, 2017 10.18632/oncotarget.21468
OpenAccess publication A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts
Nobis, M.; Herrmann, D.; Warren, S. C.; Kadir, S.; Leung, W.; Killen, M.; Magenau, A.; Stevenson, D.; Lucas, M. C.; Reischmann, N.; Vennin, C.; Conway, J. R. W.; Boulghourjian, A.; Zaratzian, A.; Law, A. M.; Gallego-Ortega, D.; Ormandy, C. J.; Walters, S. N.; Grey, S. T.; Bailey, J.; Chtanova, T.; Quinn, J. M. W.; Baldock, P. A.; Croucher, P. I.; Schwarz, J. P.; Mrowinska, A.; Zhang, L.; Herzog, H.; Masedunskas, A.; Hardeman, E. C.; Gunning, P. W.; Del Monte-Nieto, G.; Harvey, R. P.; Samuel, M. S.; Pajic, M.; McGhee, E. J.; Johnsson, A. E.; Sansom, O. J.; Welch, H. C. E.; Morton, J. P.; Strathdee, D.; Anderson, K. I.; Timpson, P.
Cell Reports 21 (1) :274-288, 2017 10.1016/j.celrep.2017.09.022
GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer
Martinelli, P.; Carrillo-de Santa Pau, E.; Cox, T.; Sainz, B., Jr.; Dusetti, N.; Greenhalf, W.; Rinaldi, L.; Costello, E.; Ghaneh, P.; Malats, N.; Buchler, M.; Pajic, M.; Biankin, A. V.; Iovanna, J.; Neoptolemos, J.; Real, F. X.
GUT 66 (9) :1665-1676, 2017 10.1136/gutjnl-2015-311256
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer
Harris, N. L.; Vennin, C.; Conway, J. R.; Vine, K. L.; Pinese, M.; Cowley, M. J.; Shearer, R. F.; Lucas, M. C.; Herrmann, D.; Allam, A. H.; Pajic, M.; Morton, J. P.; Australian Pancreatic Cancer Genome, Initiative; Biankin, A. V.; Ranson, M.; Timpson, P.; Saunders, D. N.
ONCOGENE 36 (30) :4288-4298, 2017 10.1038/onc.2017.63
Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?
Chin, V.; Vennin, C.; Timpson, P.; Pajic, M.
MOLECULAR & CELLULAR ONCOLOGY 4 (5) :e1333973, 2017 10.1080/23723556.2017.1333973