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85 items matching your search terms.
OpenAccess publication Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells
Cantley, J.; Burchfield, J. G.; Pearson, G. L.; Schmitz-Peiffer, C.; Leitges, M.; Biden, T. J.
DIABETES 58 (8) :1826-34, 2009 db09-0132 [pii] 10.2337/db09-0132
OpenAccess publication Bad news for beta-cell apoptosis
Thomas, H. E.; Biden, T. J.;
DIABETES 58 (8) :1725-7, 2009
OpenAccess publication Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling
Akerfeldt, M. C.; Howes, J.; Chan, J. Y.; Stevens, V. A.; Boubenna, N.; McGuire, H. M.; King, C.; Biden, T. J.; Laybutt, D. R.
DIABETES 57 (11) :3034-44, 2008
OpenAccess publication The diverse roles of protein kinase C in pancreatic beta-cell function
Biden, T. J.; Schmitz-Peiffer, C.; Burchfield, J. G.; Gurisik, E.; Cantley, J.; Mitchell, C. J.; Carpenter, L.
BIOCHEMICAL SOCIETY TRANSACTIONS 36 (Pt 5) :916-9, 2008
OpenAccess publication Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes
Schmitz-Peiffer, C.;Biden, T. J. :
DIABETES 57 (7) :1774-83, 2008
OpenAccess publication Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism
Roberts, C. G.;Gurisik, E.;Biden, T. J.;Sutherland, R. L.;Butt, A. J. :
MOLECULAR CANCER THERAPEUTICS 6 (10) :2777-85, 2007
OpenAccess publication Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
Laybutt, D. R.;Preston, A. M.;Akerfeldt, M. C.;Kench, J. G.;Busch, A. K.;Biankin, A. V.;Biden, T. J. :
DIABETOLOGIA 50 (4) :752-63, 2007
OpenAccess publication Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle
Cazzolli, R.;Mitchell, T. W.;Burchfield, J. G.;Pedersen, D. J.;Turner, N.;Biden, T. J.;Schmitz-Peiffer, C. :
DIABETOLOGIA 50 (8) :1732-42, 2007
OpenAccess publication Inhibition of PKCvarepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance
Schmitz-Peiffer, C.;Laybutt, D. R.;Burchfield, J. G.;Gurisik, E.;Narasimhan, S.;Mitchell, C. J.;Pedersen, D. J.;Braun, U.;Cooney, G. J.;Leitges, M.;Biden, T. J. :
Cell Metabolism 6 (4) :320-8, 2007
Phosphorylation of nonmuscle myosin heavy chain IIA on Ser1917 is mediated by protein kinase C beta II and coincides with the onset of stimulated degranulation of RBL-2H3 mast cells
Ludowyke, R. I.;Elgundi, Z.;Kranenburg, T.;Stehn, J. R.;Schmitz-Peiffer, C.;Hughes, W. E.;Biden, T. J. :
JOURNAL OF IMMUNOLOGY 177 (3) :1492-9, 2006
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes
Kjorholt, C.;Akerfeldt, M. C.;Biden, T. J.;Laybutt, D. R. :
DIABETES 54 (9) :2755-63, 2005
Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis
Busch, A. K.;Gurisik, E.;Cordery, D. V.;Sudlow, M.;Denyer, G. S.;Laybutt, D. R.;Hughes, W. E.;Biden, T. J. :
DIABETES 54 (10) :2917-24, 2005
PKC alpha is activated but not required during glucose-induced insulin secretion from rat pancreatic islets
Carpenter, L.;Mitchell, C. J.;Xu, Z. Z.;Poronnik, P.;Both, G. W.;Biden, T. J. :
DIABETES 53 (1) :53-60, 2004
Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C theta
Burchfield, J. G.;Lennard, A. J.;Narasimhan, S.;Hughes, W. E.;Wasinger, V. C.;Corthals, G. L.;Okuda, T.;Kondoh, H.;Biden, T. J.;Schmitz-Peiffer, C. :
JOURNAL OF BIOLOGICAL CHEMISTRY 279 (18) :18623-32, 2004
Phospholipase D1 regulates secretagogue-stimulated insulin release in pancreatic beta-cells
Hughes, W. E.;Elgundi, Z.;Huang, P.;Frohman, M. A.;Biden, T. J. :
JOURNAL OF BIOLOGICAL CHEMISTRY 279 (26) :27534-41, 2004
Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice
Cooney, G. J.;Lyons, R. J.;Crew, A. J.;Jensen, T. E.;Molero, J. C.;Mitchell, C. J.;Biden, T. J.;Ormandy, C. J.;James, D. E.;Daly, R. J. :
EMBO JOURNAL 23 (3) :582-93, 2004