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Search results for mouse

568 items matching your search terms.
  1. Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse

    The small GTPase RhoA is a master regulator of signalling in cell-extracellular matrix interactions. RhoA signalling is critical to many cellular processes ...

    Located in Research / … / CIRCA / CIRCA publications
  2. Characterization of neuropeptide Y2 receptor protein expression in the mouse brain. I. Distribution in cell bodies and nerve terminals

    Neuropeptide Y (NPY), a 36-amino-acid peptide, mediates biological effects by activating Y1, Y2, Y5, and y6 receptors. NPY neurons innervate many brain ...

    Located in Research / Publications Search
  3. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

    Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death; identifying PDAC enablers may reveal potential therapeutic targets. Expression of the ...

    Located in Research / Publications Search
  4. The Delta133p53 isoform and its mouse analogue Delta122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2

    A number of naturally occurring isoforms of the tumour suppressor protein p53 have been discovered, which appear to have differing roles in tumour prevention ...

    Located in Research / Publications Search
  5. The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer

    Hedgehog (Hh) signaling regulates cell fate and self-renewal in development and cancer. Canonical Hh signaling is mediated by Hh ligand binding to the receptor ...

    Located in Research / Publications Search
  6. Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer

    The zinc finger protein LMO4 is overexpressed in a high proportion of breast carcinomas. Here, we report that overexpression of a mouse mammary tumor virus ...

    Located in Research / Publications Search
  7. Single cell transcriptome atlas of mouse mammary epithelial cells across development

    BACKGROUND: Heterogeneity within the mouse mammary epithelium and potential lineage relationships have been recently explored by single-cell RNA profiling. To ...

    Located in Research / Publications Search
  8. Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of Elf5

    BACKGROUND: Elf5, an epithelial specific Ets transcription factor, plays a crucial role in the pregnancy-associated development of the mouse mammary gland. ...

    Located in Research / Publications Search
  9. Molecular Genetics Located in Research / Research services
  10. miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma

    Inactivation of the p53 tumor suppressor pathway allows cell survival in times of stress and occurs in many human cancers; however, normal embryonic stem cells ...

    Located in Research / Publications Search
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Latest news

ACRF INCITe Centre for world-class cancer imaging launches at the Garvan Institute

ACRF INCITe Centre for world-class cancer imaging launches at the Garvan Institute

30 June 2022
Clinical trial to test potential new combination therapy for aggressive breast cancer

Clinical trial to test potential new combination therapy for aggressive breast cancer

21 June 2022
Refining the teaching tools by creating better scientific animations

Refining the teaching tools by creating better scientific animations

10 June 2022
Stem-cell models reveal glaucoma secrets

Stem-cell models reveal glaucoma secrets

09 June 2022
More news

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We acknowledge the Gadigal and Gundangara peoples, the traditional custodians of the lands on which the Garvan Institute and the ABR are located. We pay respects to Elders, past, present and future, and recognise their continuing connection and contribution to this land.

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