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Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice
Non-alcoholic steatohepatitis (NASH) is a liver disease with the potential to lead to cirrhosis and hepatocellular carcinoma. Interleukin-6 (IL-6) has been ...
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Beta-cell function and human islet transplantation: can we improve?
Islet transplantation, a therapeutic option to treat type 1 diabetes, is not yet as successful as whole-pancreas transplantation as a treatment for diabetes. ...
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Disentangling Tfr cells from Treg cells and Tfh cells: How to untie the Gordian knot
T follicular regulatory (Tfr) cells are a subpopulation of Treg cells that have adopted the T follicular helper cell program to localize to the B-cell ...
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Hypoxia-inducible factor-1? regulates ? cell function in mouse and human islets
Hypoxia-inducible factor-1? (HIF-1?) is a transcription factor that regulates cellular stress responses. While the levels of HIF-1? protein are tightly ...
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A monoclonal antibody suitable for the radioimmunoassay of prolactin in human serum
Monoclonal antibodies directed toward human PRL (hPRL) have been produced by fusion of mouse myeloma cells (Sp2/0-Ag 14) with spleen cells from mice immunized ...
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Rapid phenotyping of knockout mice to identify genetic determinants of bone strength.
The genetic determinants of osteoporosis remain poorly understood and there is a large unmet need for new treatments in our aging society. Thus, new approaches ...
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B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans
Humoral immune defects are described in 9 patients from 5 families with STK4 deficiency. A mouse model carrying the novel p.Y88del show that these defects are ...
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Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family
A novel gene product, GPR74, with homology to the seven transmembrane-domain receptor superfamily, has been cloned. GPR74 has been identified from the ...
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Behavioural profile of a new mouse model for NPY deficiency
The abundantly expressed neuropeptide Y (NPY) plays an important role in anxiety and stress reactivity, as exogenous NPY administration reduces anxiety-like ...
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Differentiation of adult mouse olfactory precursor cells into hair cells in vitro
Many forms of deafness result from degeneration of the sensory cells for hearing, the hair cells in the cochlea. Stem cells offer a potential cell-based ...
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