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Preparation of an awake mouse for recording neural responses and injecting tracers
It is well known that anesthesia alters neural response properties in various regions of the brain. In the auditory system, fundamental response properties of ...
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Metabolomic analysis of insulin resistance across different mouse strains and diets
Insulin resistance is a major risk factor for many diseases. However, its underlying mechanism remains unclear in part because it is triggered by a complex ...
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Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes
AIMS/HYPOTHESIS: Type 2 diabetes mellitus is associated with reduced incretin effects. Although previous studies have shown that hyperglycaemia contributes to ...
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Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored ...
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Do transmembrane domain neuregulin 1 mutant mice exhibit a reliable sensorimotor gating deficit?
Evidence suggests that the heterozygous transmembrane domain mutant mouse model for the schizophrenia candidate gene neuregulin 1 (Nrg1 HET) exhibits a deficit ...
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Projections from the ventral nucleus of the lateral lemniscus to the cochlea in the mouse
Auditory efferents originate in the central auditory system and project to the cochlea. Although the specific anatomy of the olivocochlear (OC) efferents can ...
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Rho kinase inhibition blocks pancreatic ductal adenocarinoma invasion and tumor growth
The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently ...
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Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin
Prolactin (PRL) is one of several polypeptide factors known to exert trophic effects on the prostate. We have previously reported a dramatic prostate ...
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Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth
The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently ...
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Behavioural characteristics of the Prader-Willi syndrome related biallelic Snord116 mouse model
Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric ...
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