-
B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans
Humoral immune defects are described in 9 patients from 5 families with STK4 deficiency. A mouse model carrying the novel p.Y88del show that these defects are ...
Located in
Research
/
…
/
CIRCA
/
CIRCA publications
-
Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes
AIMS/HYPOTHESIS: Type 2 diabetes mellitus is associated with reduced incretin effects. Although previous studies have shown that hyperglycaemia contributes to ...
Located in
Research
/
Publications Search
-
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored ...
Located in
Research
/
…
/
CIRCA
/
CIRCA publications
-
Do transmembrane domain neuregulin 1 mutant mice exhibit a reliable sensorimotor gating deficit?
Evidence suggests that the heterozygous transmembrane domain mutant mouse model for the schizophrenia candidate gene neuregulin 1 (Nrg1 HET) exhibits a deficit ...
Located in
Research
/
Publications Search
-
Projections from the ventral nucleus of the lateral lemniscus to the cochlea in the mouse
Auditory efferents originate in the central auditory system and project to the cochlea. Although the specific anatomy of the olivocochlear (OC) efferents can ...
Located in
Research
/
…
/
CIRCA
/
CIRCA publications
-
Rho kinase inhibition blocks pancreatic ductal adenocarinoma invasion and tumor growth
The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently ...
Located in
Research
/
…
/
CIRCA
/
CIRCA publications
-
Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin
Prolactin (PRL) is one of several polypeptide factors known to exert trophic effects on the prostate. We have previously reported a dramatic prostate ...
Located in
Research
/
Publications Search
-
Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth
The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently ...
Located in
Research
/
…
/
CIRCA
/
CIRCA publications
-
Alpha-actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle
Approximately one billion people worldwide are homozygous for a stop codon polymorphism in the ACTN3 gene (R577X) which results in complete deficiency of the ...
Located in
Research
/
Publications Search
-
Behavioural characteristics of the Prader-Willi syndrome related biallelic Snord116 mouse model
Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric ...
Located in
Research
/
Publications Search
