-
Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth
The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently ...
Located in
Research
/
…
/
CIRCA
/
CIRCA publications
-
Behavioural characteristics of the Prader-Willi syndrome related biallelic Snord116 mouse model
Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric ...
Located in
Research
/
Publications Search
-
Accelerating functional gene discovery in osteoarthritis
Osteoarthritis causes debilitating pain and disability, resulting in a considerable socioeconomic burden, yet no drugs are available that prevent disease onset ...
Located in
Research
/
…
/
CIRCA
/
CIRCA publications
-
Alpha-actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle
Approximately one billion people worldwide are homozygous for a stop codon polymorphism in the ACTN3 gene (R577X) which results in complete deficiency of the ...
Located in
Research
/
Publications Search
-
Direct evidence for transport of RNA from the mouse brain to the germline and offspring
BACKGROUND: The traditional concept that heritability occurs exclusively from the transfer of germline-restricted genetics is being challenged by the ...
Located in
Research
/
…
/
CIRCA
/
CIRCA publications
-
The NSAID sulindac is chemopreventive in the mouse distal colon but carcinogenic in the proximal colon
BACKGROUND AND AIMS: The non-steroidal anti-inflammatory drug sulindac is an effective chemopreventive agent in sporadic colorectal cancer but its potential ...
Located in
Research
/
Publications Search
-
Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo
Parkinson's disease is a chronic neurodegenerative disease characterized by a significant loss of dopaminergic neurons within the substantia nigra pars ...
Located in
Research
/
Publications Search
-
Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signaling networks and conserved oncogenic pathways
IntroductionAlthough aberrant tyrosine kinase signaling characterizes particular breast cancer subtypes, a global analysis of tyrosine phosphorylation in mouse ...
Located in
Research
/
Publications Search
-
A/Prof Maija Kohonen-Corish
Professor Kohonen-Corish has 25-year track record of discovery in cancer research, including cancer genetics, translational research and the development of ...
Located in
About us
/
People
-
The RalA GTPase Is a Central Regulator of Insulin Exocytosis from Pancreatic Islet Beta Cells
RalA is a small GTPase that is thought to facilitate exocytosis through its direct interaction with the mammalian exocyst complex. In this study, we report an ...
Located in
Research
/
Publications Search
