-
Endogenous peptide YY and neuropeptide Y inhibit colonic ion transport, contractility and transit differentially via Y(1) and Y(2) receptors
Background & purpose: Peptide YY (PYY) and neuropeptide Y (NPY) activate Y receptors, targets under consideration as treatments for diarrhoea and other ...
Located in
Research
/
Publications Search
-
An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance
A common nonsense polymorphism (R577X) in the ACTN3 gene results in complete deficiency of the fast skeletal muscle fiber protein alpha-actinin-3 in an ...
Located in
Research
/
Publications Search
-
Dr Daniel Suan
Dan grew up in Perth and studied medicine at UWA before moving to Sydney to train as an Immunologist at Westmead Hospital and St Vincent's Hospital. After ...
Located in
About us
/
People
-
Investigation of the role of prolactin in the development and function of the lacrimal and harderian glands using genetically modified mice
PURPOSE: To determine whether prolactin receptor is essential for normal development and function of the lacrimal gland and whether hyperprolactinemia can ...
Located in
Research
/
Publications Search
-
p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes
While current thinking posits that insulin signaling to glucose transporter 4 (GLUT4) exocytic translocation and glucose uptake in skeletal muscle and ...
Located in
Research
/
Publications Search
-
Insulin action under arrestin
Insulin signaling is key to the etiology of metabolic syndrome. Recent work (Luan et al., 2009) uncovers a role for beta-arrestin, previously known to control ...
Located in
Research
/
Publications Search
-
The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets
AIMS/HYPOTHESIS: We determined whether high-glucose-induced beta cell dysfunction is associated with oxidative stress in the DBA/2 mouse, a mouse strain ...
Located in
Research
/
Publications Search
-
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
Resisting and tolerating microbes are alternative strategies to survive infection, but little is known about the evolutionary mechanisms controlling this ...
Located in
Research
/
…
/
CIRCA
/
CIRCA publications
-
Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation
Elf5 is an epithelial-specific ETS factor. Embryos with a null mutation in the Elf5 gene died before embryonic day 7.5, indicating that Elf5 is essential ...
Located in
Research
/
Publications Search
-
Bidirectional GPR119 Agonism Requires Peptide YY and Glucose for Activity in Mouse and Human Colon Mucosa
The lipid sensor G protein-coupled receptor 119 (GPR119) is highly expressed by enteroendocrine L-cells and pancreatic beta-cells that release the hormones, ...
Located in
Research
/
…
/
CIRCA
/
CIRCA publications
