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Latest News07 Sep 2016

'Forgotten molecule' takes centre stage in cancer gene silencing

Research from Garvan 's Genomics and Epigenetics Division has shed new light on how genes are silenced in cancer. The findings reveal how DNA becomes chemically decorated (methylated) at key sites across the genome in cancer cells, leading to gene silencing – and show that the protein MBD2 plays a direct role in determining the location of these sites.