Catia Moutinho

Associate Director

Catia Moutinho

Cátia completed her Bachelor of Science in Biology, at the University of Azores, Portugal, before completing her master’s degree in Medicine and Molecular Oncology at the University of Porto, Portugal. Afterwards, Cátia did her PhD in Biomedicine at University of Barcelona, Spain, graduating in 2014

Biography

Cátia completed her Bachelor of Science in Biology, at the University of Azores, Portugal, before completing her master’s degree in Medicine and Molecular Oncology at the University of Porto, Portugal. Afterwards, Cátia did her PhD in Biomedicine at University of Barcelona, Spain, graduating in 2014. With many years of experience as a senior scientist, Cátia moved to Australia to become a group leader of the Single-cell Genomics Development wet lab research team at the Garvan-Weizmann Centre for Cellular Genomics (GWCCG), in the Garvan Institute of Molecular Research in Sydney. Currently, Cátia is the Associate Director of the GWCCG and the leader of the same wet lab research team.

Early on, Cátia was always fascinated by the biology of Cancer and, therefore, joined the biggest cancer research centre in Spain, the group of Prof. Manel Esteller at the Spanish National Cancer Research Centre (CNIO), in Madrid. Later, the group moved to Bellvitge Biomedical Research Institute (IDIBELL) in Barcelona, where Cátia conducted her PhD on the biological and clinical impacts of epigenetics mechanisms in cancer therapy. After her graduation, and during her postdoc years, Cátia obtained another master’s degree in Clinical Trials and Medical Affairs. During her career, C­átia garnered remarkable expertise in the genetics, and epigenetics of cancer. She also grew a passion towards single-cell technology, and, therefore, joined one of the biggest single-cell genomics group in Europe, the Single-Cell Genomics Lab led by Dr. Holger Heyn, at the National Centre of Genomics Analysis (CNAG-CRG) in Barcelona, Spain. Later, and with an extensive experience in the wet lab, Cátia moved to Australia where she is currently working at the GWCCG.   

Through her career, Cátia has played a major role in delivering many milestones in cancer biology. She has made highly significant contributions to the field with more than 50 authored publications. Along with her team, Cátia has played an integral role in developing the single-cell technology that has boosted a number of collaborations the GWCCG is involved in.

Cátia completed her Bachelor of Science in Biology, at the University of Azores, Portugal, before completing her master’s degree in Medicine and Molecular Oncology at the University of Porto, Portugal. Afterwards, Cátia did her PhD in Biomedicine at University of Barcelona, Spain, graduating in 2014. With many years of experience as a senior scientist, Cátia moved to Australia to become a group leader of the Single-cell Genomics Development wet lab research team at the Garvan-Weizmann Centre for Cellular Genomics (GWCCG), in the Garvan Institute of Molecular Research in Sydney. Currently, Cátia is the Associate Director of the GWCCG and the leader of the same wet lab research team.

Early on, Cátia was always fascinated by the biology of Cancer and, therefore, joined the biggest cancer research centre in Spain, the group of Prof. Manel Esteller at the Spanish National Cancer Research Centre (CNIO), in Madrid. Later, the group moved to Bellvitge Biomedical Research Institute (IDIBELL) in Barcelona, where Cátia conducted her PhD on the biological and clinical impacts of epigenetics mechanisms in cancer therapy. After her graduation, and during her postdoc years, Cátia obtained another master’s degree in Clinical Trials and Medical Affairs. During her career, C­átia garnered remarkable expertise in the genetics, and epigenetics of cancer. She also grew a passion towards single-cell technology, and, therefore, joined one of the biggest single-cell genomics group in Europe, the Single-Cell Genomics Lab led by Dr. Holger Heyn, at the National Centre of Genomics Analysis (CNAG-CRG) in Barcelona, Spain. Later, and with an extensive experience in the wet lab, Cátia moved to Australia where she is currently working at the GWCCG.   

Through her career, Cátia has played a major role in delivering many milestones in cancer biology. She has made highly significant contributions to the field with more than 50 authored publications. Along with her team, Cátia has played an integral role in developing the single-cell technology that has boosted a number of collaborations the GWCCG is involved in.

Education

• 2016: Master in Clinical Trials and Medical Affairs, CESIF (Centro de Estudos Superiores de La Industria Farmaceutica (CESIF) - Barcelona, Spain
• 2010-2014: PhD in Biomedicine, University of Barcelona - Spain
• 2013: Radioactive Facilities Supervisor Course for not encapsulated material by Acesoria de Protección y Control en Radiological, sl. - Barcelona, Spain
• 2005-2008: Master in Medicine and Molecular Oncology, Faculty of Medicine, University of Porto - Porto, Portugal
• 2007: Initial Teacher Training Course (CAP). Certform - Porto, Portugal
• 2005: Post-graduate studies in Informed Consent. School of Law, Coimbra University - Coimbra, Portugal
• 2004-2005: Post-graduate studies in Forensic Sciences, Institute of Biomedical Sciences, University of Porto (ICBAS) - Porto, Portugal
• 1999-2002: Bachelor’s degree in Biology, University of Azores - Azores, Portugal

Selected Publications

Selected Publications: [Most recent first; FORMAT – see examples above]

 

Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment. Rubio-Perez C, Planas-Rigol E, Trincado JL, Bonfill-Teixidor E, Arias A, Marchese D, Moutinho C, Serna G, Pedrosa L, Iurlaro R, Martínez-Ricarte F, Escudero L, Cordero E, Cicuendez M, Ruiz S, Parra G, Nuciforo P, Gonzalez J, Pineda E, Sahuquillo J, Tabernero J, Heyn H, Seoane J. Nat Commun. 2021 Mar 8;12(1):1503. doi: 10.1038/s41467-021-21789-x. PMID: 33686071

https://pubmed.ncbi.nlm.nih.gov/33686071/

 

Use of patient derived orthotopic xenograft models for real-time therapy guidance in a pediatric sporadic malignant peripheral nerve sheath tumor. Fernández-Rodríguez J, Morales La Madrid A, Gel B, Castañeda Heredia A, Salvador H, Martínez-Iniesta M, Moutinho C, Morata J, Heyn H, Blanco I, Creus-Bachiller E, Capella G, Farré L, Vidal A, Soldado F, Krauel L, Suñol M, Serra E, Villanueva A, Lázaro C. Ther Adv Med Oncol. 2020 Jul 3;12:1758835920929579. doi: 10.1177/1758835920929579. eCollection 2020. PMID: 32670419

https://pubmed.ncbi.nlm.nih.gov/32670419/

 

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer. Morral C, Stanisavljevic J, Hernando-Momblona X, Mereu E, Álvarez-Varela A, Cortina C, Stork D, Slebe F, Turon G, Whissell G, Sevillano M, Merlos-Suárez A, Casanova-Martí À, Moutinho C, Lowe SW, Dow LE, Villanueva A, Sancho E, Heyn H, Batlle E. Cell Stem Cell. 2020 Jun 4;26(6):845-861.e12. doi: 10.1016/j.stem.2020.04.012. Epub 2020 May 11. PMID: 32396863

https://pubmed.ncbi.nlm.nih.gov/32396863/

 

Sampling time-dependent artifacts in single-cell genomics studies. Massoni-Badosa R, Iacono G, Moutinho C, Kulis M, Palau N, Marchese D, Rodríguez-Ubreva J, Ballestar E, Rodriguez-Esteban G, Marsal S, Aymerich M, Colomer D, Campo E, Julià A, Martín-Subero JI, Heyn H. Genome Biol. 2020 May 11;21(1):112. doi: 10.1186/s13059-020-02032-0. PMID: 32393363

https://pubmed.ncbi.nlm.nih.gov/32393363/


Benchmarking single-cell RNA-sequencing protocols for cell atlas projects.
Mereu E, Lafzi A, Moutinho C, Ziegenhain C, McCarthy DJ, Álvarez-Varela A, Batlle E, Sagar, Grün D, Lau JK, Boutet SC, Sanada C, Ooi A, Jones RC, Kaihara K, Brampton C, Talaga Y, Sasagawa Y, Tanaka K, Hayashi T, Braeuning C, Fischer C, Sauer S, Trefzer T, Conrad C, Adiconis X, Nguyen LT, Regev A, Levin JZ, Parekh S, Janjic A, Wange LE, Bagnoli JW, Enard W, Gut M, Sandberg R, Nikaido I, Gut I, Stegle O, Heyn H.Nat Biotechnol. 2020 Jun;38(6):747-755. doi: 10.1038/s41587-020-0469-4. Epub 2020 Apr 6.PMID: 32518403

https://pubmed.ncbi.nlm.nih.gov/32518403/

 

Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis. Vara C, Paytuví-Gallart A, Cuartero Y, Le Dily F, Garcia F, Salvà-Castro J, Gómez-H L, Julià E, Moutinho C, Aiese Cigliano R, Sanseverino W, Fornas O, Pendás AM, Heyn H, Waters PD, Marti-Renom MA, Ruiz-Herrera A. Cell Rep. 2019 Jul 9;28(2):352-367.e9. doi: 10.1016/j.celrep.2019.06.037. PMID: 31291573

https://pubmed.ncbi.nlm.nih.gov/31291573/

 

Epigenetic loss of the endoplasmic reticulum-associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming. Llinàs-Arias P, Rosselló-Tortella M, López-Serra P, Pérez-Salvia M, Setién F, Marin S, Muñoz JP, Junza A, Capellades J, Calleja-Cervantes ME, Ferreira HJ, de Moura MC, Srbic M, Martínez-Cardús A, de la Torre C, Villanueva A, Cascante M, Yanes O, Zorzano A, Moutinho C, Esteller M.JCI Insight. 2019 Mar 7;5(8):e125888. doi: 10.1172/jci.insight.125888.PMID: 30843871 

https://pubmed.ncbi.nlm.nih.gov/30843871/

 

Germline variation in O6-methylguanine-DNA methyltransferase (MGMT) as cause of hereditary colorectal cancer. Belhadj S, Moutinho C, Mur P, Setien F, Llinàs-Arias P, Pérez-Salvia M, Pons T, Pineda M, Brunet J, Navarro M, Capellá G, Esteller M, Valle L. Cancer Lett. 2019 Apr 10;447:86-92. doi: 10.1016/j.canlet.2019.01.019. Epub 2019 Jan 21.PMID: 30677446

 https://pubmed.ncbi.nlm.nih.gov/30677446/

 

Tutorial: guidelines for the experimental design of single-cell RNA sequencing studies. Lafzi A, Moutinho C, Picelli S, Heyn H. Nat Protoc. 2018 Dec;13(12):2742-2757. doi: 10.1038/s41596-018-0073-y. PMID: 30446749

 https://pubmed.ncbi.nlm.nih.gov/30446749/

 

In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma. Pérez-Salvia M, Aldaba E, Vara Y, Fabre M, Ferrer C, Masdeu C, Zubia A, Sebastian ES, Otaegui D, Llinàs-Arias P, Rosselló-Tortella M, Berdasco M, Moutinho C, Setien F, Villanueva A, González-Barca E, Muncunill J, Navarro JT, Piris MA, Cossio FP, Esteller M. Haematologica. 2018 Nov;103(11):e537-e540. doi: 10.3324/haematol.2018.189241. Epub 2018 Jun 7.

PMID: 29880608

https://pubmed.ncbi.nlm.nih.gov/28881673/


Epigenetic inactivation of the BRCA1 interactor SRBC and resistance to oxaliplatin in colorectal cancer.
Moutinho C, Martinez-Cardús A, Santos C, Navarro-Pérez V, Martínez-Balibrea E, Musulen E, Carmona FJ, Sartore-Bianchi A, Cassingena A, Siena S, Elez E, Tabernero J, Salazar R, Abad A, Esteller M.J Natl Cancer Inst. 2014 Jan;106(1):djt322. doi: 10.1093/jnci/djt322. Epub 2013 Nov 22.PMID: 24273214 

https://pubmed.ncbi.nlm.nih.gov/24273214/

 

Epidermal growth factor receptor structural alterations in gastric cancer.

Moutinho C, Mateus AR, Milanezi F, Carneiro F, Seruca R, Suriano G.BMC Cancer. 2008 Jan 16;8:10. doi: 10.1186/1471-2407-8-10.PMID: 18199332 

https://pubmed.ncbi.nlm.nih.gov/18199332/