Deborah Burnett

Research Officer - Immunogenomics Lab

Deborah Burnett

Deborah originally trained as a veterinarian, working in emergency practice in Australia and New Zealand before transitioning into medical research. She undertook her honours at the WEHI under the supervision of Prof Ben Kile, investigating the mechanisms of platelet survival. In 2015-2019 she compl

Research Level

Research Officer

Biography

Deborah originally trained as a veterinarian, working in emergency practice in Australia and New Zealand before transitioning into medical research. She undertook her honours at the WEHI under the supervision of Prof Ben Kile, investigating the mechanisms of platelet survival. In 2015-2019 she completed a PhD at the Garvan in the laboratory of Prof Chris Goodnow. Her PhD investigated the role of B cells in tolerance and immunity. It had joint aims of understanding the mechanisms of the autoimmune diseases, LRBA deficiency and understanding the role of self-binding B cells in immune responses.

In 2019 she was awarded a DAAD visiting Scholar Fellowship and in 2020 she was awarded an NHMRC Emerging Leadership Fellowship allowing her to continue her research. 

Deborah originally trained as a veterinarian, working in emergency practice in Australia and New Zealand before transitioning into medical research. She undertook her honours at the WEHI under the supervision of Prof Ben Kile, investigating the mechanisms of platelet survival. In 2015-2019 she completed a PhD at the Garvan in the laboratory of Prof Chris Goodnow. Her PhD investigated the role of B cells in tolerance and immunity. It had joint aims of understanding the mechanisms of the autoimmune diseases, LRBA deficiency and understanding the role of self-binding B cells in immune responses.

In 2019 she was awarded a DAAD visiting Scholar Fellowship and in 2020 she was awarded an NHMRC Emerging Leadership Fellowship allowing her to continue her research. 

Awards and Honours

Awarded NHMRC, Emerging Leadership 1 Investigator Grant (2020-ongoing).
Award for Outstanding Contribution to Research by a Higher Degree Student, UNSW Medicine Education and Research Awards (2019).
Dean’s Award for Outstanding PhD Theses, UNSW Graduate Research School (2019).
Garvan Best PhD Thesis Award (2019).
DAAD Short Term Research Grant at the DKFZ, Germany (2019).
Research Excellence Award, University of NSW, (2015- 2018).
Australian Postgraduate Award, University of NSW (2015- 2018).
Immunology and Cell Biology Journal Publication of the Year Award (2018).
Australian Society of Immunology New Investigator, Finalist (2018).
The H.R. Carne Medal for First Place in BSc(Vet) (Hons) Degree (2010).
University of Sydney Honours Scholarship (2010).
Alan W Harris Honours Medical Research Scholarship (2010).
University College Graduate Scholarship (2010).

Selected Publications

Burnett, DL, Schofield, P, Langley, DL, Jackson, J, Bourne, K, Wilson, E, Porebski, BT, Buckle, A, Brink, R, Goodnow, CC & Christ, D 2020 ‘Confirmational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens’ PNAS 

Singh, M, Jackson, JL, Wang, JJ, Schofield, P, Field, MA, Koppstein, D, Peters, TJ, Burnett, DL…. Reed, JH 2020 ‘Lymphoma driver mutations in the pathogenic evolution of an iconic human autoantibody’ Cell, DOI:10.1016/j.cell.2020.01.029

Burnett, DL, Reed, JH, Christ, D & Goodnow CC 2019 ‘Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity’ Immunol Rev, DOI:10.1111/imr.12808.

Burnett, DL, Langley, DB, Schofield, P, Hermes, JR, Chan, TD, Jackson, J, Bourne, K, Reed, JH, Patterson, K, Porebski, BT, Christ, D & Goodnow, CC 2018 ‘Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination’ Science, DOI:10.1126/science.aao3859

Burnett, D, Parish, I, Masle-Farquhar, E, Brink, R & Goodnow, C 2017 ‘Murine LRBA-deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation’, Immunol Cell Biol, DOI:10.1038/icb.2017.50