Dr Eva Chan

Senior Research Officer/ Analyst - Human Comparative and Prostate Cancer Genomics Lab

Dr Eva Chan

Dr Eva Chan is a senior Bioinformatics Scientist in the Human Comparative and Prostate Cancer Genomics Lab at The Garvan Institute of Medial Research. She has over a decade of experience in the development and application of computational and statistical approaches for genetics and genomics studies.

Biography

Dr Eva Chan is a senior Bioinformatics Scientist in the Human Comparative and Prostate Cancer Genomics Lab at The Garvan Institute of Medial Research. She has over a decade of experience in the development and application of computational and statistical approaches for genetics and genomics studies. Eva's research passion is in understanding genetic variation and how it translates to phenotypic differences, including diseases and population diversity.

Prior to joining Garvan in 2013, Eva was immersed in agricultural bioinformatics research spending several years leading a Statistical Genetics team at Monsanto, and as a post-doctoral fellow at the University of California-Davis in USA and at CSIRO's Livestock Industries in Queensland. 

At the Garvan, Eva's research is focused on human genomic diversity and cancer genomics, with particular interest in large-scale structural variations.

Dr Eva Chan is a senior Bioinformatics Scientist in the Human Comparative and Prostate Cancer Genomics Lab at The Garvan Institute of Medial Research. She has over a decade of experience in the development and application of computational and statistical approaches for genetics and genomics studies. Eva's research passion is in understanding genetic variation and how it translates to phenotypic differences, including diseases and population diversity.

Prior to joining Garvan in 2013, Eva was immersed in agricultural bioinformatics research spending several years leading a Statistical Genetics team at Monsanto, and as a post-doctoral fellow at the University of California-Davis in USA and at CSIRO's Livestock Industries in Queensland. 

At the Garvan, Eva's research is focused on human genomic diversity and cancer genomics, with particular interest in large-scale structural variations.

Awards and Honours

2019 Ridley Ken Davies Award

Education

B.Sc Biochemistry, University of Queensland (2001)
B.Sc Hon. (Bioinformatics), University of New South Wales (2002)
Ph.D. Computational Genetics, University of New South Wales (2007)

Patents

Garcia-Andres S, Bachlava E, Chan EKF, Joobeur T, King JJ, et al. Melon Plants with Improved Disease Tolerance. U.S. patent US14/880,050 filed 09 October 2015 and granted 16 October 2018.

Braun CJ III, Chan EKF, Garvey GS, Jones CM, Just BJ, et al. Selection of mature fruit color in pepper plants. U.S. patent US14/304,722, filed 13 June 2014 and granted 08 August 2017.

Black L, Chan EKF, Colcol JF, Jones R, Kramer C, Xiang W. Disease resistance loci in Onion. U.S. patent US14/550,705 filed 21 November 2014.

Caldwell D, Chan EKF, De Vries J, Joobeur T, King J, et al. Methods and Compositions for identifying Downy Mildew resistance in cucumber plants. U.S. patent US12/910,478 filed October 2010 and granted 19 August 2014.

Selected Publications

Gong T, Hayes VM, Chan EKFC. Shiny-SoSV: A web app for interactive evaluation of somatic structural variant calls. bioRxiv. 2019; doi 10.1101/668723.

Jaratlerdsiri W, Chan EKF, Gong T, et al. Whole Genome Sequencing Reveals Elevated Tumor Mutational Burden and Initiating Driver Mutations in African Men with Treatment-Naive High-Risk Prostate Cancer. Cancer Research. 2019; 78 (24), 6736-6746.

Chan EKF, Cameron DL, Petersen DC, et al. Optical mapping reveals a higher level of genomic architecture of chained fusions in cancer. Genome Research. 2018; 28(5): 726-738.

Jaratlerdsiri W*, Chan EKF*, Petersen DC*, et al. Next generation mapping reveals novel large genomic rearrangements in prostate cancer. Oncotarget. 2017; 8(14): 23588-23602. (* equal first authors)

Chan EKF, Hardie RA, Petersen DC, et al. Revised timeline and distribution of the earliest diverged human maternal lineages in southern Africa. PLoS ONE. 2015; 10(3): e0121223.

Morris A, Heinze A, Chan EKF, Smith AB, Hayes VM. First Ancient Mitochondrial Genome from a Pre-Pastoralist Southern African. Genome Biology and Evolution. 2014; 6(10): 2647-2653.

Chan EKF, Rowe HC, Corwin JA, Joseph B, Kliebenstein  DJ. Combining genome wide association mapping and transcriptional networks to identify novel genes controlling glucosinolates in Arabidopsis thaliana. PloS Biology. 2011; 9(8): e1001125.

Chan EKF, Rowe HC, Hansen BG, Kliebenstein DJ. The Complex Genetic Architecture of the Metabolome. PLoS Genetics. 2010; 6(11): e1001198.

Chan EKF, Rowe HC, Kliebenstein DJ. Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide association mapping. Genetics. 2010; 185: 991 – 1007.

Chan EKF, Nagaraj SH, Reverter A. The evolution of tropical adaptation: Comparing Taurine and Zebu cattle. Animal Genetics. 2010; 41(5): 467 – 477.

Chan EKF and Reverter A.  The combined effect of SNP-marker and phenotype attributes in genomewide association studies. Animal Genetics. 2009; 40(2): 149-156.

Reverter A, Chan EKF. Combining partial correlation and an information theory approach to the reversed-engineering of gene co-expression networks. Bioinformatics. 2008; 24(21):2491-2497.