Joanne’s research focuses on autoimmune diseases, particularly the origin and role of autoantibodies. Joanne completed her PhD at Flinders University, investigating antigen expression and autoantibody specificity in Sjogren’s syndrome and lupus.
Upon completion of her PhD she received an NHMRC Fellowship to undertake postdoctoral training at New York University. At NYU, Joanne studied how autoantibodies mediate tissue injury in neonatal lupus.
In 2013 Joanne returned to Australia and joined Prof Christopher Goodnow’s group at the Australian National University, with the goal of developing new genomic approaches to study autoimmune disease. She then moved with Prof Goodnow in 2015 to establish an Immunogenomics lab at the Garvan Institute.
Joanne's current research uses next generation sequencing and single cell transcriptomics to study antibody repertoires and genetic variants in patients with autoimmune disease.
Awards and Honours
2017 - Lupus Travel Grant and Scientific Presentation Award
2017 - NSW Health Early - Mid Career Fellowship
2017 - Young Garvan Award
2016 - Arthritis Australia SA LSS Support Group Grant
2013 - Lupus Foundation of America Grant
2012 – Arthritis Foundation of America Postdoctoral Fellowship
2012 – American Heart Association Postdoctoral Fellowship
2011 – Sjogren’s syndrome Foundation of America Outstanding Abstract Award
2010 – NHMRC CJ Martin Overseas Training Fellowship
2009 – Australian Rheumatology Association New Investigator Award
2008/7/6 – Australian Rheumatology Association Philip Alper’s Prize and Travel Grant
2004 – Amgen Prize for best honours thesis in South Australia
2004 – Australian Biotechnology Association honours thesis prize
2004 – University Medal
2004 – Bachelor of Biotechnology (Honours – First Class), Flinders University of South Australia - Australia
Burnett DL, Langley DB, Schofield P, Hermes JR, Chan TD, Jackson J, Bourne K, Reed JH, Patterson K, Porebski BT, Brink R, Christ D, Goodnow CC. (2018) Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination. Science, 360: 223-6.
Reed, J.H., Gorny, M.K., Li, L., J.P. Buyon and Clancy, R.M. (2017) Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus. J Autoimmun, 79: 99-104.
Reed, J.H., Jackson, J., Christ, D., Goodnow, C.C. (2016) Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization. J Exp Med 213(7):1255-65.
Sabouri Z, Perotti S, Spierings E, Humburg P, Yabas M, Bergmann H, Horikawa K, Roots C, Lambe S, Young C, Andrews TD, Field M, Enders A, Reed JH, Goodnow CC (2016) IgD attenuates the IgM-induced anergy response in transitional and mature B cells. Nat Commun, 7:103381.
Reed, J.H. and Gordon, T.P. (2016) Ro60-associated RNA takes its toll on disease pathogenesis. Nat Rev Rheumatol, 12(3): 136-8.
Reed, J.H., Sim, S., Wolin, S.L., Clancy, R.M. and J.P. Buyon (2013). Ro60 requires Y RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus. J Immunol, 191: 110-116
Reed, J.H., Jain, M., Lee, K., Kandimalla, E.R., Faridi, M.H., Buyon, J.P., Gupta, V. and R. M. Clancy (2013). Complement Receptor 3 influences Toll-like receptor 7/8 dependent inflammation: Implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins. J Biol Chem, 288: 9077-9083
Reed, J.H., Clancy, R.M., Lee, K.H., Saxena, A., Izmirly, P.M. and J.P. Buyon (2012). Umbilical cord blood levels of maternal antibodies reactive with p200 and full length Ro52 in the assessment of risk for cardiac manifestations of neonatal lupus. Arthritis Care Res 64, 1373-1381
Reed, J.H., Clancy, R.M., Purcell, A.W., Kim, M.Y., Gordon, T.P. and J.P. Buyon (2011). Beta2-glycoprotein I and protection from anti-SSA/Ro60-associated cardiac manifestations of neonatal lupus. J Immunol, 187: 520-526.
Reed, J.H., Jackson, M.W. and T.P. Gordon (2010). A Ro60 apotope is cryptic on the intracellular autoantigen. Lupus, 19: 107-108
Reed, J.H., Dudek, N.L., Osborne, S.E., Kaufman, K.M., Jackson, M.W., Purcell, A.W. and T.P. Gordon (2010). Reactivity with dichotomous determinants of Ro60 stratifies autoantibody responses in lupus and primary Sjogren’s syndrome. Arthritis Rheum 6: 1448-1456
Reed, J.H., Thurgood, L., Gordon, D.L. and T.P. Gordon (2010). Differential activation of complement by apoptotic cells opsonized with anti-Ro60 and anti-La autoantibodies. Scand J Immunol, 72: 260-261.
Reed, J.H., Giannakopoulos, B., Jackson, M.W., Krilis, S.A. and T.P. Gordon (2009). Ro60 functions as a receptor for beta2-glycoprotein I on apoptotic cells. Arthritis and Rheumatism, 60: 860-869 (with accompanying editorial: Clancy R.M. Arthritis Rheum 60: 636-8)
Reed, J.H., Jackson, M.W. and T.P. Gordon (2008). A B cell apotope of Ro60 in systemic lupus erythematosus. Arthritis Rheum, 58: 1125-1129
Reed, J.H., Neufing, P.J., Jackson, M.W., Clancy, R.M., Macardle, P.J., Buyon, J.P. and T.P. Gordon (2007). Different temporal expression of immunodominant Ro60/60kD-SSA and La/SSB apotopes. Clin Exp Immunol, 148: 153-160