Dr Matthew Hobbs

As a student I trained in genetics and then molecular biology. As a postdoctoral researcher at the University of Queensland, and later at the University of Sydney, I worked on projects analysing sequences of genes responsible for production of prominent polymorphic bacterial surface antigens. Subseq

Biography

As a student I trained in genetics and then molecular biology. As a postdoctoral researcher at the University of Queensland, and later at the University of Sydney, I worked on projects analysing sequences of genes responsible for production of prominent polymorphic bacterial surface antigens.

Subsequently I abandoned experimental benchwork and pursued my interest in computational biology. I worked as a bioinformatician with the Australian National Genomic Information Service and also with private companies providing bioinformatics services and training.

When genomic sequencing approaches were introduced to research in animal species I joined a group at the University of Sydney applying genomic technologies to the Australian dairy industry. While with this group I was involved in the bovine genome sequencing project.

Immediately before joining Garvan I was with the Australian Museum’s Wildlife Genomics group working on the transcriptome and genome of the koala. I remain involved in the maintenance and development of the Online Mendelian Inheritance in Animals (OMIA) database and website.

At the Garvan Institute I am working on a project characterising the roles of tiny RNAs in animal epigenetics.

As a student I trained in genetics and then molecular biology. As a postdoctoral researcher at the University of Queensland, and later at the University of Sydney, I worked on projects analysing sequences of genes responsible for production of prominent polymorphic bacterial surface antigens.

Subsequently I abandoned experimental benchwork and pursued my interest in computational biology. I worked as a bioinformatician with the Australian National Genomic Information Service and also with private companies providing bioinformatics services and training.

When genomic sequencing approaches were introduced to research in animal species I joined a group at the University of Sydney applying genomic technologies to the Australian dairy industry. While with this group I was involved in the bovine genome sequencing project.

Immediately before joining Garvan I was with the Australian Museum’s Wildlife Genomics group working on the transcriptome and genome of the koala. I remain involved in the maintenance and development of the Online Mendelian Inheritance in Animals (OMIA) database and website.

At the Garvan Institute I am working on a project characterising the roles of tiny RNAs in animal epigenetics.

Education

1990 - PhD, University of New South Wales - Australia
1983 - BSc (Hons), University of New South Wales - Australia

Selected Publications

Hobbs, M., Pavasovic, A., King, A.G., Prentis, P.J., Eldridge, M.D., Chen, Z., Colgan, D.J., Polkinghorne, A., Wilkins, M.R., Flanagan, C., Gillett, A., Hanger, J., Johnson, R.N., Timms, P. (2014). A transcriptome resource for the koala (Phascolarctos cinereus): insights into koala retrovirus transcription and sequence diversity. BMC Genomics 15:786.

Nicholas, F.W. and Hobbs, M. (2013). Mutation discovery for Mendelian traits in non-laboratory animals: a review of achievements up to 2012. Animal Genetics 45:157–170.

Whan, V., Hobbs, M., McWilliam, S., Lynn, D.J., Strandberg Lutzow, Y., Khatkar, M., Barendse, W., Raadsma, H. and Tellam, R.L. (2010). Bovine proteins containing poly-glutamine repeats are often polymorphic and enriched for components of transcriptional regulatory complexes. BMC Genomics 11:654.

Khatkar, M.S., Hobbs, M., Neuditschko, M., Sölkner, J., Nicholas, F.W. and Raadsma, H.W. (2010). Assignment of chromosomal locations for unassigned SNPs/scaffolds based on pair-wise linkage disequilibrium estimates. BMC Bioinformatics 11:171.

The Bovine Genome Annotation and Sequencing Consortium. (2009). The genome sequence of taurine cattle: A window to ruminant biology and evolution. Science 324 (5926):522-8.

International Bovine BAC Mapping Consortium (2007). A physical map of the bovine genome. Genome Biol 8(8): R165.

Liao, W., Collins, A., Hobbs, M., Khatkar, M.S., Luo, J., Nicholas, F.W. (2007). A comparative location database (CompLDB): map integration within and between species. Mamm Genome 18(5): 287-99.

Clarke, B.C., Hobbs, M., Skylas, D. and Appels, R. (2000) Genes active in developing wheat endosperm. Funct Integr Genomics 1:44-55

Stevenson, G., Neal, B., Liu, D., Hobbs, M., Packer, N.H., Batley, M., Redmond, J.W., Lindquist, L. and Reeves, P.R. (1994) Structure of the O-antigen of E. coli K-12 and the sequence of its rfb gene cluster. J Bacteriol 176: 4144-4156.

Hobbs, M., and Mattick, J.S. (1993) Common components in the assembly of type 4 fimbriae, DNA transfer systems, filamentous phage and protein-secretion apparatus: a general system for the formation of surface-associated protein complexes. Mol Microbiol 10:233-43