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Arcadi Cipponi

Dr Arcadi Cipponi

Senior Research Officer
Genomic Cancer Medicine Lab

Dr Arcadi Cipponi completed his degree in Molecular Biology at the University of Milan, Italy in 1998. He became fascinated by the field of cancer immunology and immunotherapy and in 2008 gained a PhD in Molecular and Cellular Pathology at the University of Parma, Italy. His studies shed light on the mechanisms driving anti-tumour immune response elicited by engineered T lymphocytes expressing tumour specific antigens.

He then moved to the Ludwig Institute for Cancer Research in Brussels, where he joined the group of Professor Pierre Coulie as Postdoctoral Fellow. His studies involved some fundamental aspects of the anti-tumour immune response, like the transcriptional profile of tumour infiltrating CD8 T lymphocytes in human melanoma samples, and the characterisation of intratumoral lymphoid neogenesis in human subcutaneous metastasis.

In 2011 he joined the group of Professor David Thomas at the Peter MacCallum Cancer Centre in Melbourne, where he focused his attention on defining the general principles governing how human cancer cells adapt and evolve in response to selective pressures imposed by therapeutics. These studies emphasise the molecular and genetic mechanisms used by tumour cells to increase the levels of genetic instability and accelerate stress-induced adaptive evolution.

In 2014, the group moved to The Kinghorn Cancer Centre at the Garvan Institute of Medical Research in Sydney, and Arcadi is actively involved in the development of in vitro and in silico models to define cancer risks associated with germline mutations in tumour suppressor genes.


  • 2006FNRS (Belgian National Funds for Scientific Research) fellowship
  • 2012Peter MacCallum Cancer Institute Foundation Grant
  • 2015NHMRC Project Grant “Stress-induced genomic instability as a driver of adaptive responses in human cancer cells”.

Selected Publications

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  • 2020
    Science (New York, N.Y.)10.1126/science.aau8768

    MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer.

    Arcadi Cipponi, David L Goode, Justin Bedo, Mark J McCabe, Marina Pajic, David R Croucher, Alvaro Gonzalez Rajal, Simon R Junankar, Darren N Saunders, Pavel Lobachevsky, Anthony T Papenfuss, Danielle Nessem, Max Nobis, Sean C Warren, Paul Timpson, Mark Cowley, Ana C Vargas, Min R Qiu, Daniele G Generali, Shivakumar Keerthikumar, Uyen Nguyen, Niall M Corcoran, Georgina V Long, Jean-Yves Blay, David M Thomas
  • 2019
    Scientific reports10.1038/s41598-019-52000-3

    Development and validation of a targeted gene sequencing panel for application to disparate cancers.

    Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita M C De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, Simon A Mueller, Ruta Gupta, Ann I McCormack, Marcel E Dinger, Mark J Cowley,
  • 2019
    Human mutation10.1002/humu.23739

    A quantitative model to predict pathogenicity of missense variants in the TP53 gene.

    Cristina Fortuno, Arcadi Cipponi, Mandy L Ballinger, Sean V Tavtigian, Magali Olivier, Vatsal Ruparel, Ygal Haupt, Sue Haupt, International Sarcoma Kindred Study, Kathy Tucker, Amanda B Spurdle, David M Thomas, Paul A James
  • 2016
    The Lancet. Oncology10.1016/S1470-2045(16)30147-4

    Monogenic and polygenic determinants of sarcoma risk: an international genetic study.

    Mandy L Ballinger, David L Goode, Isabelle Ray-Coquard, Paul A James, Gillian Mitchell, Eveline Niedermayr, Ajay Puri, Joshua D Schiffman, Gillian S Dite, Arcadi Cipponi, Robert G Maki, Andrew S Brohl, Ola Myklebost, Eva W Stratford, Susanne Lorenz, Sung-Min Ahn, Jin-Hee Ahn, Jeong Eun Kim, Sue Shanley, Victoria Beshay, Robert Lor Randall, Ian Judson, Beatrice Seddon, Ian G Campbell, Mary-Anne Young, Rajiv Sarin, Jean-Yves Blay, Seán I O'Donoghue, David M Thomas,