Dr Swetansu Pattnaik

Data Scientist Research Officer - Genomic Cancer Medicine

Dr Swetansu Pattnaik

Swetansu gained predoctoral experience in Bioinformatics and Biophysics from Indian Institute of Sciences, Bangalore. His doctoral studies focussed on deriving structural and functional insights into catalytically active RNA molecules, ribozymes, utilising a combination of experimental and computati

Biography

Swetansu gained predoctoral experience in Bioinformatics and Biophysics from Indian Institute of Sciences, Bangalore. His doctoral studies focussed on deriving structural and functional insights into catalytically active RNA molecules, ribozymes, utilising a combination of experimental and computational approaches. This work lead to a conceptual advancement in understanding RNA mediated catalysis which materialised from a prestigious collaboration between SUNY Buffalo, USA and University of Tokyo, Japan. 

Prior to joining Garvan, Swetansu's post doctoral experience in the Industry (Strand LifeSciences and DuPont Pioneer) allowed him to solve problems in diverse areas of bioinformatics research. His work has contributed towards biomarker discovery in oral cancer cohorts, whole genome/transcriptome assembly and annotation of non-model plant species, development of gene discovery and prioritisation algorithms for improving complex traits of agriculturally relevant crops. 

Presently, at Garvan, Swetansu develops computational approaches towards understanding the underlying mechanisms of acquired resistance in ovarian cancer patients, the molecular basis of evolution of cold tumours along with developing algorithms to improve patient stratification by leveraging diverse omics datasets. 

Swetansu gained predoctoral experience in Bioinformatics and Biophysics from Indian Institute of Sciences, Bangalore. His doctoral studies focussed on deriving structural and functional insights into catalytically active RNA molecules, ribozymes, utilising a combination of experimental and computational approaches. This work lead to a conceptual advancement in understanding RNA mediated catalysis which materialised from a prestigious collaboration between SUNY Buffalo, USA and University of Tokyo, Japan. 

Prior to joining Garvan, Swetansu's post doctoral experience in the Industry (Strand LifeSciences and DuPont Pioneer) allowed him to solve problems in diverse areas of bioinformatics research. His work has contributed towards biomarker discovery in oral cancer cohorts, whole genome/transcriptome assembly and annotation of non-model plant species, development of gene discovery and prioritisation algorithms for improving complex traits of agriculturally relevant crops. 

Presently, at Garvan, Swetansu develops computational approaches towards understanding the underlying mechanisms of acquired resistance in ovarian cancer patients, the molecular basis of evolution of cold tumours along with developing algorithms to improve patient stratification by leveraging diverse omics datasets. 

Education

PhD SUNY-Buffalo USA and University of Tokyo Japan
2009

Selected Publications

Elizabeth L. Christie, Swetansu Pattnaik, Jessica Beach, Anthony Copeland, Nineveh Rashoo, Sian Fereday, Joy Hendley, Kathryn Alsop, Samuel L. Brady, Greg Lamb, Ahwan Pandey, Anna deFazio, Heather Thorne, Andrea Bild & David D.L. Bowtell. Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer. Nature Communications 2019,10:1295

Swetansu Pattnaik, Saurabh Gupta, Arjun A Rao and Binay Panda. SInC: an accurate and fast error-model based simulator for SNPs, Indels and CNVs coupled with a read generator for short-read sequence data. BMC Bioinformatics 2014,15:40

Neeraja M Krishnan*, Swetansu Pattnaik*, Prachi Jain, Prakhar Gaur, Rakshit Choudhary, Srividya Vaidyanathan, SA Deepak, Arun K Hariharan, PG Bharath Krishna, Jayalakshmi Nair, Linu Varghese, Naveen K Valivarthi, Kunal Dhas, Krishna Ramaswamy and Binay Panda. A draft of the genome and four transcriptomes of a medicinal and pesticidal angiosperm Azadirachta indica. BMC Genomics 2012, 13:464

Shinya Tsukiji, Swetansu Pattnaik & Hiroaki Suga. An alcohol dehydrogenase ribozyme. Nature Structural Biology 2003, 10: 713717