Prof Vanessa Hayes

Prof Hayes completed a PhD at the University of Groningen, The Netherlands in 1999, defining the genetic landscape of key regulator genes driving common human cancers. Returning to South Africa briefly, she headed a Genetics Laboratory focused on genetic risk factors associated with HIV/AIDS. Her in

Research Level

Professor

Biography

Prof Hayes completed a PhD at the University of Groningen, The Netherlands in 1999, defining the genetic landscape of key regulator genes driving common human cancers. Returning to South Africa briefly, she headed a Genetics Laboratory focused on genetic risk factors associated with HIV/AIDS. Her interest in prostate cancer sparked by the late Prof Chris Heyns (1949-2014).

In 2003, she joined the Garvan Institute of Medical Research where she led a Cancer Genetics group focused on defining prostate cancer genetic risk factors in Australian men. This work awarded her the Cancer Institute of New South Wales Premier’s Award for Cancer Research Fellow (2007), an Australian Young Tall Poppy Award for Science (2008) and the Australian Academy of Science Inaugural Ruth Stephens Gani Medal for Human Genetics (2008).

Driven by advances in technology, in 2008 she moved to the Children’s Cancer Institute of Australia to establish one of the countries first next generation sequencing research laboratories. She used this technology to drive two large efforts, namely the Southern African Genome Project (Nature 2010) and the Tasmanian Devil Genome Project (PNAS 2011). These efforts resulted in representing Australia as a Fulbright Professional Scholar (Penn State University) and a Professorship at the J. Craig Venter Institute in San Diego. 

In 2014, Prof Hayes returned full-time to Australia and the Garvan Institute of Medical Research as the University of Sydney’s Petre Chair of Prostate Cancer Research, where she is continuing her research efforts in human comparative and prostate cancer genomics. She has maintained her interest in technology development.

Find out more

Video

Prof Hayes completed a PhD at the University of Groningen, The Netherlands in 1999, defining the genetic landscape of key regulator genes driving common human cancers. Returning to South Africa briefly, she headed a Genetics Laboratory focused on genetic risk factors associated with HIV/AIDS. Her interest in prostate cancer sparked by the late Prof Chris Heyns (1949-2014).

In 2003, she joined the Garvan Institute of Medical Research where she led a Cancer Genetics group focused on defining prostate cancer genetic risk factors in Australian men. This work awarded her the Cancer Institute of New South Wales Premier’s Award for Cancer Research Fellow (2007), an Australian Young Tall Poppy Award for Science (2008) and the Australian Academy of Science Inaugural Ruth Stephens Gani Medal for Human Genetics (2008).

Driven by advances in technology, in 2008 she moved to the Children’s Cancer Institute of Australia to establish one of the countries first next generation sequencing research laboratories. She used this technology to drive two large efforts, namely the Southern African Genome Project (Nature 2010) and the Tasmanian Devil Genome Project (PNAS 2011). These efforts resulted in representing Australia as a Fulbright Professional Scholar (Penn State University) and a Professorship at the J. Craig Venter Institute in San Diego. 

In 2014, Prof Hayes returned full-time to Australia and the Garvan Institute of Medical Research as the University of Sydney’s Petre Chair of Prostate Cancer Research, where she is continuing her research efforts in human comparative and prostate cancer genomics. She has maintained her interest in technology development.

Find out more

Video

Education

1999 - PhD (Cancer Genetics), University of Groningen, The Netherlands
1996 - MSc (Human Genetics), University of Stellenbosch, South Africa
1993 - BSc Honours (Human Genetics), University of Stellenbosch, South Africa
1992 - BSc, University of Stellenbosch, South Africa

Selected Publications

Petersen DC, Jaratlerdsiri W, van Wyk A, Chan EKF, Fernandez P, Lyons RJ, Mutambirw SBA, van der Merwe A, Venter PA, Bates W, Bornman MSR, Hayes VMAfrican KhoeSan ancestry linked to high-risk prostate cancer. BMC Med Genomics. 2019 Jun 4;12(1):82.

Blackburn J, Vecchiarelli S, Heyer EE, Patrick SM, Lyons RJ, Jaratlerdsiri W, van Zyl S, Bornman MSR, Mercer TR, Hayes VMTMPRSS2-ERG fusions linked to prostate cancer racial health disparities: A focus on Africa. Prostate. 2019 Jul;79(10):1191-1196.

Heyer EE, Deveson IW, Wooi D, Selinger CI, Lyons RJ, Hayes VM, O'Toole SA, Ballinger ML, Gill D, Thomas DM, Mercer TR, Blackburn J. Diagnosis of fusion genes using targeted RNA sequencing. Nat Commun. 2019 Mar 27;10(1):1388.

Hayes VM, Jaratlerdsiri W, Bornman MSR. Prostate cancer genomics and racial health disparity. Oncotarget. 2018 Nov 30;9(94):36650-36651.

Jaratlerdsiri W, Chan EKF, Gong T, Petersen DC, Kalsbeek AMF, Venter PA, Stricker PD, Bornman MSR, Hayes VMWhole-Genome Sequencing Reveals Elevated Tumor Mutational Burden and Initiating Driver Mutations in African Men with Treatment-Naïve, High-Risk Prostate Cancer. Cancer Res. 2018 Dec 15;78(24):6736-6746.

Chan EKF, Cameron DL, Petersen DC, Lyons RJ, Baldi BF, Papenfuss AT, Thomas DM, Hayes VMOptical mapping reveals a higher level of genomic architecture of chained fusions in cancer. Genome Res. 2018 May;28(5):726-738.

Kalsbeek AMF, Chan EKF, Grogan J, Petersen DC, Jaratlerdsiri W, Gupta R, Lyons RJ, Haynes AM, Horvath LG, Kench JG, Stricker PD, Hayes VMAltered mitochondrial genome content signals worse pathology and prognosis in prostate cancer. Prostate. 2018 Jan;78(1):25-31.

Skoglund P, Thompson JC, Prendergast ME, Mittnik A, Sirak K, Hajdinjak M, Salie T, Rohland N, Mallick S, Peltzer A, Heinze A, Olalde I, Ferry M, Harney E, Michel M, Stewardson K, Cerezo-Román JI, Chiumia C, Crowther A, Gomani-Chindebvu E, Gidna AO, Grillo KM, Helenius IT, Hellenthal G, Helm R, Horton M, López S, Mabulla AZP, Parkington J, Shipton C, Thomas MG, Tibesasa R, Welling M, Hayes VM, Kennett DJ, Ramesar R, Meyer M, Pääbo S, Patterson N, Morris AG, Boivin N, Pinhasi R, Krause J, Reich D. Reconstructing Prehistoric African Population Structure. Cell. 2017 Sep 21;171(1):59-71.e21.

Jaratlerdsiri W, Chan EKF, Petersen DC, Yang C, Croucher PI, Bornman MSR, Sheth P, Hayes VMNext generation mapping reveals novel large genomic rearrangements in prostate cancer. Oncotarget. 2017 Apr 4;8(14):23588-23602.

Kalsbeek AM, Chan EF, Grogan J, Petersen DC, Jaratlerdsiri W, Gupta R, Lyons RJ, Haynes AM, Horvath LG, Kench JG, Stricker PD, Hayes VMMutational load of the mitochondrial genome predicts pathological features and biochemical recurrence in prostate cancer. Aging (Albany NY). 2016 Oct 5;8(11):2702-2712.

McCrow JP, Petersen DC, Louw M, Chan EK, Harmeyer K, Vecchiarelli S, Lyons RJ, Bornman MS, Hayes VMSpectrum of mitochondrial genomic variation and associated clinical presentation of prostate cancer in South African men. Prostate. 2016 Mar;76(4):349-58.

Chan EK, Hardie RA, Petersen DC, Beeson K, Bornman RM, Smith AB, Hayes VMRevised timeline and distribution of the earliest diverged human maternal lineages in southern Africa. PLoS One. 2015 Mar 25;10(3):e0121223.

Morris AG, Heinze A, Chan EK, Smith AB, Hayes VMFirst ancient mitochondrial human genome from a prepastoralist southern African. Genome Biol Evol. 2014 Sep 10;6(10):2647-53.

Petersen DC, Libiger O, Tindall EA, Hardie RA, Hannick LI, Glashoff RH, Mukerji M; Indian Genome Variation Consortium, Fernandez P, Haacke W, Schork NJ, Hayes VMComplex patterns of genomic admixture within southern Africa. PLoS Genet. 2013;9(3):e1003309.

Schuster SC, Miller W, Ratan A, Tomsho LP, Giardine B, Kasson LR, Harris RS, Petersen DC, Zhao F, Qi J, Alkan C, Kidd JM, Sun Y, Drautz DI, Bouffard P, Muzny DM, Reid JG, Nazareth LV, Wang Q, Burhans R, Riemer C, Wittekindt NE, Moorjani P, Tindall EA, Danko CG, Teo WS, Buboltz AM, Zhang Z, Ma Q, Oosthuysen A, Steenkamp AW, Oostuisen H, Venter P, Gajewski J, Zhang Y, Pugh BF, Makova KD, Nekrutenko A, Mardis ER, Patterson N, Pringle TH, Chiaromonte F, Mullikin JC, Eichler EE, Hardison RC, Gibbs RA, Harkins TT, Hayes VMComplete Khoisan and Bantu genomes from southern Africa. Nature. 2010 Feb 18;463(7283):943-7.