Our goal is to transform the future of intravital imaging: 5x Faster. 5x Brighter. 5x Deeper.
By looking into tumour cell microenvironments, where interactions between cancer cells and immune cells are complex,
dynamic and changing, we can see in ways we've never been able to see before — in vivo — that is, inside living tissue.
The new technologies use cutting-edge molecular probes in combination with rapid and sensitive imaging and adaptive optics. New endomicroscopic lenses, which are the width of a hair, allow the study of deeply buried tumours with greater clarity. Fluorescence lifetime imaging is a powerful technology to watch, track and quantify cell biology events as they happen. This allows a precise spatiotemporal readout of molecular and cellular behaviour during tissue homeostasis as well as disease initiation, progression and response to treatment. Using optical window imaging coupled with motion-corrected FLIM-FRET read-out of protein activity inside the primary tumour further allows for a temporal resolution of pharmacodynamics of cancer relevant protein inhibition at the primary tumour site.
The insights we'll gain will help us 'reprogram' the immunosuppressive environment of all cancers. The possibilities for advancing our research are infinite.
Galene Image Stabilization (eLife, 2018)
Immune cells swarming with molecular activity (Cell Reports, 2017)