Kendelle J. Murphy, Daniel A. Reed, Claire Vennin, James R.W. Conway, Morghan C. Lucas, Sean C. Warren, Joanna N. Skhinas, Max Nobis, Cecilia R Chambers, Astrid Magneau, Xanthe L. Metcalf, Elysse C Filipe, Gretel Major, Ashleigh Parkin, Brooke A Pereira, Romain Bidanel, Anaiis Zaratzian, Andrew Da Silva, Lea Abdulkhalek, Australian Pancreatic Genome Initiative (APGI), Anthony J Gill , Angela Chou, Amber L. Johns, Andrew Burgess, C Elizabeth Caldon, Lisa Horvath, Roger Daly1, Nikolaj Gadegaard, Andrew V Biankin, Jaswinder Samra, Owen J. Sansom, Jennifer P. Morton, Yingxiao Wang, Thomas R. Cox, Marina Pajic, David Herrmann# and Paul Timpson#. |
James R. W. Conway et al., Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse.Sci. Adv.9,eadf9063(2023).DOI:10.1126/sciadv.adf9063 Apoptotic cell fragments locally activate tingible body macrophages in the germinal center Grootveld AK, Kyaw W, Panova V, Lau AWY, Ashwin E, Seuzaret G, Dhenni R, Bhattacharyya ND, Khoo WH, Biro M, Mitra T, Meyer-Hermann M, Bertolino P, Tanaka M, Hume DA, Croucher PI, Brink R, Nguyen A, Bannard O, Phan TG.Cell. 2023 Mar 16;186(6):1144-1161.e18. doi: 10.1016/j.cell.2023.02.004. Epub 2023 Mar 2.PMID: 36868219 Free article.
Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy Yam AO, Bailey J, Lin F, Jakovija A, Youlten SE, Counoupas C, Gunzer M, Bald T, Woodruff TM, Triccas JA, Goldstein LD, Gallego-Ortega D, Grey ST, Chtanova T.Cancer Res. 2023 Apr 14;83(8):1315-1328. doi: 10.1158/0008-5472.CAN-21-4025.PMID: 36787115 Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma Hastings JF, Latham SL, Kamili A, Wheatley MS, Han JZR, Wong-Erasmus M, Phimmachanh M, Nobis M, Pantarelli C, Cadell AL, O'Donnell YEI, Leong KH, Lynn S, Geng FS, Cui L, Yan S, Achinger-Kawecka J, Stirzaker C, Norris MD, Haber M, Trahair TN, Speleman F, De Preter K, Cowley MJ, Bogdanovic O, Timpson P, Cox TR, Kolch W, Fletcher JI, Fey D, Croucher DR.Sci Adv. 2023 Mar 3;9(9):eabp8314. doi: 10.1126/sciadv.abp8314. Epub 2023 Mar 3.PMID: 36867694
Claire Vennin#, Venessa T. Chin#, Sean C. Warren, Morghan C. Lucas, David Herrmann, Pauline Melenec, Stacey N. Walters, Astrid Magenau, Amr H. Allam, Rachael A. McCloy, James R.W. Conway, Mark Pinese, Alice Boulghourjian, Anaiis Zaratzian, Celine Heu, Adnan M. Nagrial, Angela Chou, Angela Steinmann, Alison Drury, Danielle Froio, Marc Giry-Laterriere, Nathanial L.E. Harris, Ewan J. McGhee, Renee Whan, Shane Grey, Amber L. Johns, Jaswinder S. Samra, Lorraine Chantrill, Anthony J. Gill, Andrew V. Biankin, Australian Pancreatic Cancer Genome Initiative, Yingxiao Wang, T.R. Jeffry Evans, Kurt I. Anderson, Michael S. Samuel, Andrew Burgess, Owen J. Sansom, Jennifer P. Morton, Tom Cox, Marina Pajic#* and Paul Timpson#* Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy and the onset of the metastatic niche. Science Translational Medicine, (2017).
Floerchinger A*, Murphy KJ*, Warren SC, McCulloch AT, Kyung-Lee Y, Stoehr J, Melenec P, Latham S, Metcalf X, Lee V, Rolo S, McDonald L, Mason SM, Ferrari N, Johnsson A-KE, Sansom OJ, Morton JP, Welch HCE, Blyth K, Herrmann D, Anderson KI, Timpson P# and Nobis M#. Optimizing Metastatic-Cascade-Dependent Rac1 Targeting in Breast Cancer: guidance using Optical Windows-based FRET imaging. Cell Reports, 2021 2021 Sep 14;36;11https://doi.org/10.1016/j.celrep.2021.109689
James Conway, David Herrmann, Jeff Evans, Jennifer Morton and Paul Timpson#. Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalized medicine. Gut, IF 17, (2019).
James Conway, Sean Warren, David Herrmann, Robert Shearer, Monica Killen, Pauline Melenec, Mark Pinese, Astrid Magenau, Jody Haigh, Yingxiao Wang, David Croucher, Owen Sansom, Marina Pajic, Jennifer Morton#, and Paul Timpson# Intravital imaging to monitor therapeutic response in moving hypoxic regions resistant to PI3K pathway targeting in pancreatic cancer, Cell Reports (2018).
James R.W. Conway, Claire Vennin, Sean C. Warren, Lena Wullkopf, Alice Boulghourjian, Anaiis Zaratzian, David Herrmann, Kendelle J. Murphy, Marina Pajic, Jennifer P. Morton, Thomas R. Cox# and Paul Timpson#. Three-dimensional organotypic matrices from alternative collagen sources as pre- clinical models for cell biology. Scientific Reports (2017).
Junankar S, Shay G, Jurczyluk J, Ali N, Down J, Pocock N, Parker A, Nguyen A, Sun S, Kashemirov B, McKenna CE, Croucher PI, Swarbrick A, Weilbaecher K, Phan TG, Rogers MJ. Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer. Cancer discovery 2015;5(1):35-42. doi: 10.1158/2159-8290.CD-14-0621 [published Online First: 2014/10/15]
Khoo WH, Ledergor G, Weiner A, Roden DL, Terry RL, McDonald MM, Chai RC, De Veirman K, Owen KL, Opperman KS, Vandyke K, Clark JR, Seckinger A, Kovacic N, Nguyen A, Mohanty ST, Pettitt JA, Xiao Y, Corr AP, Seeliger C, Novotny M, Lasken RS, Nguyen TV, Oyajobi BO, Aftab D, Swarbrick A, Parker B, Hewett DR, Hose D, Vanderkerken K, Zannettino ACW, Amit I, Phan TG, Croucher PI. A niche-dependent myeloid transcriptome signature defines dormant myeloma cells. Blood 2019;134(1):30-43. doi: 10.1182/blood.2018880930 [published Online First: 2019/04/27] Lawson MA, McDonald MM, Kovacic N, Hua Khoo W, Terry RL, Down J, Kaplan W, Paton-Hough J, Fellows C, Pettitt JA, Neil Dear T, Van Valckenborgh E, Baldock PA, Rogers MJ, Eaton CL, Vanderkerken K, Pettit AR, Quinn JM, Zannettino AC, Phan TG, Croucher PI. Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche. Nature communications 2015;6:8983. doi: 10.1038/ncomms9983 [published Online First: 2015/12/04]
Max Nobis, Morghan Lucas, Sean Warren, Kendelle Murphy, David Herrmann# and Paul Timpson#. Moving molecular mobility to in vivo disease settings. Journal of Cell Science (2018)
Max Nobis*, David Herrmann*, Sean C. Warren*, Douglas Strathdee, Thomas R. Cox, Kurt I. Anderson# and Paul Timpson#. Shedding new light on RhoA signalling as a drug target in vivo using a novel FRET biosensor mouse. Small GTPases. Max Nobis*, David Herrmann*, Sean C. Warren*, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, Morghan C. Lucas, David Stevenson, Nadine Reischmann, Claire Vennin, James R.W. Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M. Law, David Gallego-Ortega, Christopher J. Ormandy, Stacey N. Walters, Shane T. Grey, Jacqueline Bailey, Tatyana Chtanova, Julian Quinn, Paul A. Baldock, Peter Croucher, Juliana P. Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C Hardeman, Peter W Gunning, Gonzalo del Monte-Nieto, Richard P. Harvey, Marina Pajic, Ewan J. McGhee, Anna-Karin E. Johnsson, Owen J. Sansom, Heidi C.E. Welch, Jennifer P. Morton, Douglas Strathdee, Kurt I. Anderson# and Paul Timpson#. A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts. Cell Reports, # Corresponding (2017).
McDonald MM, Khoo WH, Ng PY, Xiao Y, Zamerli J, Thatcher P, Kyaw W, Pathmanandavel K, Grootveld AK, Moran I, Butt D, Nguyen A, Corr A, Warren S, Biro M, Butterfield NC, Guilfoyle SE, Komla-Ebri D, Dack MRG, Dewhurst HF, Logan JG, Li Y, Mohanty ST, Byrne N, Terry RL, Simic MK, Chai R, Quinn JMW, Youlten SE, Pettitt JA, Abi-Hanna D, Jain R, Weninger W, Lundberg M, Sun S, Ebetino FH, Timpson P, Lee WM, Baldock PA, Rogers MJ, Brink R, Williams GR, Bassett JHD, Kemp JP, Pavlos NJ, Croucher PI, Phan TG. Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption. Cell 2021;184(5):1330-47 e13. doi: 10.1016/j.cell.2021.02.002 [published Online First: 2021/02/27] McDonald MM, Reagan MR, Youlten SE, Mohanty ST, Seckinger A, Terry RL, Pettitt JA, Simic MK, Cheng TL, Morse A, Le LMT, Abi-Hanna D, Kramer I, Falank C, Fairfield H, Ghobrial IM, Baldock PA, Little DG, Kneissel M, Vanderkerken K, Bassett JHD, Williams GR, Oyajobi BO, Hose D, Phan TG, Croucher PI. Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood 2017;129(26):3452-64. doi: 10.1182/blood-2017-03-773341 [published Online First: 2017/05/19] Phan TG, Croucher PI. The dormant cancer cell life cycle. Nature reviews Cancer 2020;20(7):398-411. doi: 10.1038/s41568-020-0263-0 [published Online First: 2020/06/04]
Quantifying and visualising the nuances of cellular dynamics in vivo using intravital imaging Sean C. Warren#, Astrid Magenau, Max Nobis, Yousuf H. Mohammed, Pauline Mélénec, Tri Phan, Michael S. Roberts and Paul Timpson#. Galene: Correcting physiological motion blurring at the subcellular level in intravital FLIM data. eLife (2018). Palmer Prize for Innovation. |
Read more
