Dr Marcia Munoz

Senior Research Officer

I started my career as a cancer biologist focusing on the study of cell-intrinsic tumour-promoting signalling pathways. As I progressed, I developed a deep interest in the inflammatory tumour microenvironment, which led me to join Professor Wolfgang Weninger’s Immune Imaging Lab at the Centenary Institute. During my time with Professor Weninger I acquired valuable insight in immunological concepts and the opportunity to apply live imaging to study immune cell behaviour in vivo.

I have recently joined Prof Mike Rogers in the Bone Biology Division to study the interactions between tumour and stroma, and in particular, to investigate the effects of bisphosphonate drugs on the immune component of the tumour microenvironment.

Research Interests

• Tumourigenesis and the metastatic process
• Live cell imaging and intravital microscpopy
• Tumour Immunology
• Immune cell migration


2006 - PhD, Cancer Biology, Garvan Institute of Medical Research / University of New South Wales - Australia
1998 - BSc (Hons) (First Class) in Biology, Simon Bolivar University, Caracas - Venezuela

Selected Publications

*Prakash, M. D., *Munoz, M. A., Jain, R., Tong, P. L., Koskinen, A., Regner, M., Kleifeld, O., Ho, B., Olson, M., Turner, S. J., Mrass, P., Weninger, W. and Bird, P. I. (2014). "Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling." Immunity 41(6): 960-972.(Prakash et al. 2014) *Equal author contribution

Munoz, M. A., Biro, M. and Weninger, W. (2014). "T cell migration in intact lymph nodes in vivo." Current opinion in cell biology 30: 17-24.

*Biro, M., *M. A. Munoz and W. Weninger (2014). "Targeting Rho-GTPases in immune cell migration and inflammation." Br J Pharmacol. *Equal author contribution

Cheung, L., C. L. Flemming, F. Watt, N. Masada, D. M. Yu, T. Huynh, G. Conseil, A. Tivnan, A. Polinsky, A. V. Gudkov, M. A. Munoz, A. Vishvanath, D. M. Cooper, M. J. Henderson, S. P. Cole, J. I. Fletcher, M. Haber and M. D. Norris (2014). "High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)." Biochem Pharmacol 91(1): 97-108.

Haass, N. K., K. A. Beaumont, D. S. Hill, A. Anfosso, P. Mrass, M. A. Munoz, I. Kinjyo and W. Weninger (2014). "Real-time cell cycle imaging during melanoma growth, invasion, and drug response." Pigment Cell Melanoma Res 27(5): 764-776.

Beaumont, K. A., M. A. Munoz and W. Weninger (2013). "Mesenchymal cells hold the key to immune cell recruitment to and migration within melanoma." J Invest Dermatol 133(9): 2138-2140.

Henderson, M. J., M. Haber, A. Porro, M. A. Munoz, N. Iraci, C. Xue, J. Murray, C. L. Flemming, J. Smith, J. I. Fletcher, S. Gherardi, C. K. Kwek, A. J. Russell, E. Valli, W. B. London, A. B. Buxton, L. J. Ashton, A. C. Sartorelli, S. L. Cohn, M. Schwab, G. M. Marshall, G. Perini and M. D. Norris (2011). "ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux." J Natl Cancer Inst 103(16): 1236-1251.

Porro, A., M. Haber, D. Diolaiti, N. Iraci, M. Henderson, S. Gherardi, E. Valli, M. A. Munoz, C. Xue, C. Flemming, M. Schwab, J. H. Wong, G. M. Marshall, G. Della Valle, M. D. Norris and G. Perini (2010). "Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells." J Biol Chem 285(25): 19532-19543.

Pasquier, E., S. Sinnappan, M. A. Munoz and M. Kavallaris (2010). "ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties." Mol Cancer Ther 9(5): 1408-1418.

Dr Marcia Munoz

Collaborative Program

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