Prof Jacqueline Center

Lab Head - Clinical Studies and Epidemiology

Senior Research Fellow

Conjoint/Adjunct Role(s)

Senior Staff Specialist, Dept of Endocrinology, St Vincent’s Hospital

Prof Jacqueline Center qualified as an endocrinologist in 1993, obtained a Master of Epidemiology in 1995 and a PhD in 1999.  She has been working on clinical and epidemiological studies related to osteoporotic fracture and its outcomes for over 18 years and has been one of the principle researchers in the Dubbo Osteoporosis Epidemiology Study. She has pioneered work on consequences of fracture including the high risk of refracture and premature mortality that has resulted in international collaborations involving investigators from several large epidemiological studies throughout Europe, Canada and the US. 

She has also been involved in other areas of translational research and led one of the first set of studies that demonstrated a lack of treatment for osteoporosis following hip fracture and that improvement in treatment rates only occurred after initiation of treatment by hospital personnel and not information alone. This work has resulted in involvement in and recently chair of the Osteoporosis working group for the NSW Musculoskeletal Agency for Clinical Innovation (ACI) and the American Society for Bone and Mineral Research (ASBMR) Taskforce on Osteoporotic Fracture Secondary Prevention.

She is also involved in several national and international organizations including the Scientific Advisory Board of OsteoporosisAustralia, Research Committee of the Australian and New Zealand Bone and Mineral Society, and Editorial board member of BMC Geriatrics.  As a practicing endocrinologist, primarily working in the bone field she gives regular educational talks to the general public and medical practitioners.

Research Interests

Osteoporosis and its epidemiology
Fracture prediction
Fracture outcomes
Causes of mortality post fracture
Bariatric surgery and effect on bone
Regulation of bone loss

Awards and Honours

2013-2015 - John Shine Translational Fellowship
2011-2015 - NH&MRC Practitioner Fellowship
2002 - Young Investigator Award, American Society for Bone and Mineral Research
1999 - Garvan Institute of Medical Research, award for best thesis
1996 - US Endocrine Society Travel Award
1995-1998 - NH&MRC Medical Postgraduate Scholarship
1992 - RNSH Medical Staff Council Fellowship for Outstanding Achievement
1981/2 - AMSA - AMA - J. G. Hunter Research Fellowship
1981/2 - National Heart Foundation Vacation Scholarship


1999 - PhD, University of New South Wales, Sydney - Australia
1995 - MS Epidemiology, Harvard School of Public Health - USA
1993 - FRACP
1987 - MBBS (Hons) University of Sydney - Australia

Selected Publications

Center JR, White CP. Obesity: Bariatric surgery, weight loss and bone. Nat Rev Endocrinol. 2013 Nov;9(11):630-2. doi: 10.1038/nrendo.2013.189. Epub 2013 Oct 1.

Bliuc D, Nguyen ND, Nguyen TV, Eisman JA, Center JR. Compound risk of high mortality following osteoporotic fracture and re-fracture in elderly women and men. J Bone Miner Res. 2013; Apr 24. doi: 10.1002/jbmr.1968. [Epub ahead of print]

Ahmed LA, Center JR, Bjørnerem A, Bluic D, Joakimsen RM, Jørgensen L, Meyer HE, Nguyen ND, Nguyen TV, Omsland TK, Størmer J, Tell GS, van Geel TA, Eisman JA, Emaus N. Progressively increasing fracture risk with advancing age following initial incident fragility fracture. The Tromsø Study. J Bone Miner Res. 2013 Apr 9. doi: 10.1002/jbmr.1952. [Epub ahead of print]

Brzozowska MM, Sainsbury A, Eisman JA, Baldock PA, Center JR. Bariatric surgery, bone loss, obesity and possible mechanisms. Obes Rev. 2013; 14(1):52-67.

Nair P, Lee P, Reynolds C, Nguyen ND, Myburgh J, Eisman JA, Center JR. Significant perturbation of vitamin D-parathyroid-calcium axis and adverse clinical outcomes in critically ill patients. Intensive Care Med. 2013; 39(2):267-74.

Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR et al, Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet. 2012; 44(5):491-501.

Center JR, Bliuc D, Nguyen ND, Nguyen TV, Eisman JA. Osteoporosis medication and reduced mortality risk in elderly women and men. J Clin Endocrinol Metab. 2011; 96(4):1006-14.

Lee P, Eisman JA, Center JR. Vitamin D Deficiency in Critically Ill Patients is Highly Prevalent and Associated with Adverse Outcome. N Engl J Med 2009; 360(18):1912-4.

Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR. Mortality risk associated with low trauma osteoporotic fracture and subsequent fracture in men and women. JAMA 2009; 301:513-521.

Kuo I, Bluic D, Eisman JA Center JR. Successful direct intervention for osteoporosis in patients with minimal trauma fractures. Osteoporosis Int. 2007; 18(12):1633-9.

Center JR, Bliuc D, Nguyen TV, Eisman JA.  Risk of subsequent fracture after low-trauma fracture in men and women. JAMA. 2007; 297(4):387-94.

Bliuc D, Eisman JA, Center JR.  A randomized study of two different information-based interventions on the management of osteoporosis in minimal and moderate trauma fractures. Osteoporosis Int, 2006; 17(9):1309-17.

Center JR, Nguyen T, Eisman JA.  Volumetric bone density at the femoral neck provides a unitary measure of hip fracture risk for men and women.  Journal of Clinical Endocrinology and Metabolism.  2004; 89:2776-82

Center JR, Nguyen TV, Sambrook PN, Eisman JA. Hormonal and Biochemical Parameters in the Determination of Osteoporosis in Elderly Men. Journal of Clinical Endocrinology and Metabolism. 1999; 84:3626-3635.

Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA. Mortality after all Major types of Osteoporotic Fractures in Men and Women: an Observational Study. Lancet. 1999; 353:878-882.

Prof Jacqueline Center