Cancer Biology Lab

Publications

Regulation of prolactin receptor expression by the tumour promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human breast cancer cells
Ormandy, C. J.;Lee, C. S.;Kelly, P. A.;Sutherland, R. L. :
JOURNAL OF CELLULAR BIOCHEMISTRY 52(1):47-56, 1993
Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions
Oakes, S. R.;Robertson, F. G.;Kench, J. G.;Gardiner-Garden, M.;Wand, M. P.;Green, J. E.;Ormandy, C. J. :
ONCOGENE 26(4):543-53, 2007
Andy's Algorithms: new automated digital image analysis pipelines for FIJI
Law, A. M. K.; Yin, J. X. M.; Castillo, L.; Young, A. I. J.; Piggin, C.; Rogers, S.; Caldon, C. E.; Burgess, A.; Millar, E. K. A.; O'Toole, S. A.; Gallego-Ortega, D.; Ormandy, C. J.; Oakes, S. R.
Scientific Reports 7(1):15717, 2017
Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer
Caldon, C. E.; Musgrove, E.A.
Cell Division 5:2, 2010
Prolactin signaling influences the timing mechanism of the hair follicle: analysis of hair growth cycles in prolactin receptor knockout mice
Craven, A. J.;Ormandy, C. J.;Robertson, F. G.;Wilkins, R. J.;Kelly, P. A.;Nixon, A. J.;Pearson, A. J. :
ENDOCRINOLOGY 142(6):2533-9, 2001
Cdk2 regulates metastasis suppressor BRMS1
Caldon, C. E.;
CELL CYCLE 15(6):779-80, 2016
Prolactin regulates mammary epithelial cell proliferation via autocrine/paracrine mechanism
Naylor, M. J.;Lockefeer, J. A.;Horseman, N. D.;Ormandy, C. J. :
ENDOCRINE 20(1-2):111-4, 2003
The neuropeptide galanin augments lobuloalveolar development
Naylor, M. J.;Ginsburg, E.;Iismaa, T. P.;Vonderhaar, B. K.;Wynick, D.;Ormandy, C. J. :
JOURNAL OF BIOLOGICAL CHEMISTRY 278(31):29145-52, 2003
Coordinate regulation of oestrogen and prolactin receptor expression by sodium butyrate in human breast cancer cells
Ormandy, C. J.;de Fazio, A.;Kelly, P. A.;Sutherland, R. L. :
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 182(2):740-5, 1992
Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells.
Caldon, C.E.; Sergio, C.M.; Kang, J.; Muthukaruppan, A.; Boersma, M.; Stone, A.; Barraclough, J. Lee, C.S.L.; Black, M.A.; Miller, L.D.; Gee, J.M.; Nicholson, R.I.; Sutherland, R.L.; Print, C.G.; Musgrove, E.A.
MOLECULAR CANCER THERAPEUTICS 11(7):1488-99, 2012
Estradiol induction of retinoic acid receptors in human breast cancer cells
Roman, S. D.;Ormandy, C. J.;Manning, D. L.;Blamey, R. W.;Nicholson, R. I.;Sutherland, R. L.;Clarke, C. L. :
CANCER RESEARCH 53(24):5940-5, 1993
Prolactin controls mammary gland development via direct and indirect mechanisms
Brisken, C.;Kaur, S.;Chavarria, T. E.;Binart, N.;Sutherland, R. L.;Weinberg, R. A.;Kelly, P. A.;Ormandy, C. J. :
DEVELOPMENTAL BIOLOGY 210(1):96-106, 1999
The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium
Oakes, S. R.;Hilton, H. N.;Ormandy, C. J. :
BREAST CANCER RES 8(2):207, 2006
Estrogen signaling and the DNA damage response in hormone dependent breast cancers
Caldon, C. E.;
Frontiers in Oncology 4:106, 2014
Galanin regulates prolactin release and lactotroph proliferation
Wynick, D.;Small, C. J.;Bacon, A.;Holmes, F. E.;Norman, M.;Ormandy, C. J.;Kilic, E.;Kerr, N. C.;Ghatei, M.;Talamantes, F.;Bloom, S. R.;Pachnis, V. :
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95(21):12671-6, 1998
Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse
Ormandy, C. J.;Camus, A.;Barra, J.;Damotte, D.;Lucas, B.;Buteau, H.;Edery, M.;Brousse, N.;Babinet, C.;Binart, N.;Kelly, P. A. :
Genes Dev 11(2):167-78, 1997
SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice
Lindeman, G. J.;Wittlin, S.;Lada, H.;Naylor, M. J.;Santamaria, M.;Zhang, J. G.;Starr, R.;Hilton, D. J.;Alexander, W. S.;Ormandy, C. J.;Visvader, J. :
Genes Dev 15(13):1631-6, 2001
The innate and adaptive infiltrating immune systems as targets for breast cancer immunotherapy
Law, A. M.; Lim, E.; Ormandy, C. J.; Gallego-Ortega, D.
ENDOCRINE-RELATED CANCER 24(4):R123-R144, 2017
Differential expression of oestrogen regulated genes in breast cancer
Manning, D. L.;McClelland, R. A.;Knowlden, J. M.;Bryant, S.;Gee, J. M.;Green, C. D.;Robertson, J. F.;Blamey, R. W.;Sutherland, R. L.;Ormandy, C. J.;et al. :
Acta Oncologica 34(5):641-6, 1995
Transcriptional regulation of prolactin receptor gene expression by sodium butyrate in MCF-7 human breast cancer cells
Ormandy, C. J.;de Fazio, A.;Kelly, P. A.;Sutherland, R. L. :
ENDOCRINOLOGY 131(2):982-4, 1992
Prolactin and the prolactin receptor: new targets of an old hormone
Harris, J.;Stanford, P. M.;Oakes, S. R.;Ormandy, C. J. :
ANNALS OF MEDICINE 36(6):414-25, 2004
Prolactin delays hair regrowth in mice
Craven, A. J.;Nixon, A. J.;Ashby, M. G.;Ormandy, C. J.;Blazek, K.;Wilkins, R. J.;Pearson, A. J. :
JOURNAL OF ENDOCRINOLOGY 191(2):415-25, 2006
Review: Zhu, T et al. Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone. Cancer Research, 2005. 65(1): p. 317-24
Ormandy, C. J. :
Breast Cancer Online (BCO) www.bco.org 2005
Socs2 and elf5 mediate prolactin-induced mammary gland development
Harris, J.;Stanford, P. M.;Sutherland, K.;Oakes, S. R.;Naylor, M. J.;Robertson, F. G.;Blazek, K. D.;Kazlauskas, M.;Hilton, H. N.;Wittlin, S.;Alexander, W. S.;Lindeman, G. J.;Visvader, J. E.;Ormandy, C. J. :
MOLECULAR ENDOCRINOLOGY 20(5):1177-87, 2006
Static droplet array for culturing single live adherent cells in an isolated chemical microenvironment
Hassanzadeh-Barforoushi, A.; Law, A. M. K.; Hejri, A.; Asadnia, M.; Ormandy, C. J.; Gallego-Ortega, D.; Ebrahimi Warkiani, M.
LAB ON A CHIP 18(15):2156-2166, 2018
Immune system development and function in prolactin receptor-deficient mice
Bouchard, B.;Ormandy, C. J.;Di Santo, J. P.;Kelly, P. A. :
JOURNAL OF IMMUNOLOGY 163(2):576-82, 1999
A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation
Oakes, S. R.; Gallego-Ortega, D.; Stanford, P. M.; Junankar, S.; Au, W. W. Y.; Kikhtyak, Z.; von Korff, A.; Sergio, C. M.; Law, A. M. K.; Castillo, L. E.; Allerdice, S. L.; Young, A. I. J.; Piggin, C.; Whittle, B.; Bertram, E.; Naylor, M. J.; Roden, D. L.; Donovan, J.; Korennykh, A.; Goodnow, C. C.; O'Bryan, M. K.; Ormandy, C. J.
PLoS Genetics 13(11):e1007072, 2017
Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1
Caldon, C.E.; Sergio, C.M.; Burgess, A.; Deans, A.J.; Sutherland, R.L.; Musgrove, E.A.;
CELL CYCLE 12(4):606-617, 2013
Prolactin Receptor
Ormandy, C.J.;
Current Biodata - Target Protein Database 2008
Differences in degradation lead to asynchronous expression of cyclin E1 and cyclin E2 in cancer cells
Caldon, C. E.; Sergio, C.M.; Sutherland, R.L.; Musgrove, E.A.;
CELL CYCLE 12(4):596-605, 2013
Estrogen regulation of cyclin E2 requires cyclin D1, but not c-Myc
Caldon, C.E.; Sergio, C.M.; Schutte, J.; Boersma, M.N.; Sutherland, R.L.; Carroll, J.S.; Musgrove, E.A.
MOLECULAR AND CELLULAR BIOLOGY 29(17):4623-4639, 2009
Grid therapy using high definition multileaf collimators: realizing benefits of the bystander effect
Peng, V.; Suchowerska, N.; Rogers, L.; Claridge Mackonis, E.; Oakes, S.; McKenzie, D. R.
Acta Oncologica 56(8):1048-1059, 2017
Prolactin regulation of mammary gland development
Oakes, S. R.;Rogers, R. L.;Naylor, M. J.;Ormandy, C. J. :
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA 13(1):13-28, 2008
Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion
Saunders, D. N.;Hird, S. L.;Withington, S. L.;Dunwoodie, S. L.;Henderson, M. J.;Biben, C.;Sutherland, R. L.;Ormandy, C. J.;Watts, C. K. :
MOLECULAR AND CELLULAR BIOLOGY 24(16):7225-34, 2004
Mechanisms of prolactin receptor regulation in mammary gland
Ormandy, C. J.;Sutherland, R. L. :
MOLECULAR AND CELLULAR ENDOCRINOLOGY 91(1-2):C1-6, 1993
The mammary cellular hierarchy and breast cancer
Oakes, S. R.
; Gallego-Ortega, D.
; Ormandy, C. J.;
CELLULAR AND MOLECULAR LIFE SCIENCES 71(22):4301-24, 2014
Inverse regulation of oestrogen receptor and epidermal growth factor receptor gene expression in MCF-7 breast cancer cells treated with phorbol ester
Lee, C. S.;deFazio, A.;Ormandy, C. J.;Sutherland, R. L. :
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 58(3):267-75, 1996
Prostate development and carcinogenesis in prolactin receptor knockout mice
Robertson, F. G.;Harris, J.;Naylor, M. J.;Oakes, S. R.;Kindblom, J.;Dillner, K.;Wennbo, H.;Tornell, J.;Kelly, P. A.;Green, J.;Ormandy, C. J. :
ENDOCRINOLOGY 144(7):3196-205, 2003
19q12 amplified and non-amplified subsets of high grade serous ovarian cancer with overexpression of cyclin E1 differ in their molecular drivers and clinical outcomes
Aziz, D.; Etemadmoghadam, D.; Caldon, C. E.; Au-Yeung, G.; Deng, N.; Hutchinson, R.; Bowtell, D.; Waring, P.
GYNECOLOGIC ONCOLOGY 151(2):327-336, 2018
Coexpression and cross-regulation of the prolactin receptor and sex steroid hormone receptors in breast cancer
Ormandy, C. J.;Hall, R. E.;Manning, D. L.;Robertson, J. F.;Blamey, R. W.;Kelly, P. A.;Nicholson, R. I.;Sutherland, R. L. :
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 82(11):3692-9, 1997
The role of prolactin and growth hormone in mammary gland development
Kelly, P. A.;Bachelot, A.;Kedzia, C.;Hennighausen, L.;Ormandy, C. J.;Kopchick, J. J.;Binart, N. :
MOLECULAR AND CELLULAR ENDOCRINOLOGY 197(1-2):127-31, 2002
Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin
Kindblom, J.;Dillner, K.;Sahlin, L.;Robertson, F.;Ormandy, C.;Tornell, J.;Wennbo, H. :
ENDOCRINOLOGY 144(6):2269-78, 2003
Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function
Gass, S.;Harris, J.;Ormandy, C.;Brisken, C. :
J Mammary Gland Biol Neoplasia 8(3):269-85, 2003
The antiproliferative effects of progestins in T47D breast cancer cells are tempered by progestin induction of the ETS transcription factor Elf5
Hilton, H. N.; Kalyuga, M.; Cowley, M. J.; Alles, M. C.; Lee, H. J.; Caldon, C. E.; Blazek, K.; Kaplan, W.; Musgrove, E. A.; Daly, R. J.; Naylor, M. J.; Graham, J. D.; Clarke, C. L.; Ormandy, C. J.:
MOLECULAR ENDOCRINOLOGY 24(7):1380-92, 2010
Androgen regulation of prolactin-receptor gene expression in MCF-7 and MDA-MB-453 human breast cancer cells
Ormandy, C. J.;Clarke, C. L.;Kelly, P. A.;Sutherland, R. L. :
INTERNATIONAL JOURNAL OF CANCER 50(5):777-82, 1992
The Ets transcription factor Elf5 specifies mammary alveolar cell fate
Oakes, S. R.;Naylor, M. J.;Asselin-Labat, M. L.;Blazek, K. D.;Gardiner-Garden, M.;Hilton, H. N.;Kazlauskas, M.;Pritchard, M. A.;Chodosh, L. A.;Pfeffer, P. L.;Lindeman, G. J.;Visvader, J. E.;Ormandy, C. J. :
GENES & DEVELOPMENT 22(5):581-6, 2008
Mouse strain-specific patterns of mammary epithelial ductal side branching are elicited by stromal factors
Naylor, M. J.;Ormandy, C. J. :
Dev Dyn 225(1):100-5, 2002
The effect of progestins on prolactin receptor gene transcription in human breast cancer cells
Ormandy, C. J.;Graham, J.;Kelly, P. A.;Clarke, C. L.;Sutherland, R. L. :
DNA AND CELL BIOLOGY 11(10):721-6, 1992
Investigation of the role of prolactin in the development and function of the lacrimal and harderian glands using genetically modified mice
McClellan, K. A.;Robertson, F. G.;Kindblom, J.;Wennbo, H.;Tornell, J.;Bouchard, B.;Kelly, P. A.;Ormandy, C. J. :
Invest Ophthalmol Vis Sci 42(1):23-30, 2001
Meta-analysis and gene set enrichment relative to ER status reveal elevated activity of MYC and E2F in the ""basal"" breast cancer subgroup.
Alles, C.M.; Gardiner-Garden, M.; Nott, D.J.; Wang, Y.; Fuekens, J.A.; Sutherland, R.L.; Musgrove, E.A.; Ormandy, C.J.
PLoS One 4(3):e4710, 2009
Genomic telescopes
Ormandy, C. J. :
J Mammary Gland Biol Neoplasia 8(3):255-6, 2003
Solubilization and characterization of a lactogenic receptor from human placental chorion membranes
Ormandy, C. J.;Clarke, C. L.;Sutherland, R. L. :
JOURNAL OF CELLULAR BIOCHEMISTRY 43(1):1-15, 1990
Mammary gland development in prolactin receptor knockout mice
Ormandy, C. J.;Binart, N.;Kelly, P. A. :
J Mammary Gland Biol Neoplasia 2(4):355-64, 1997
Involvement of human choline kinase alpha and beta in carcinogenesis: A different role in lipid metabolism and biological functions
Gallego-Ortega, D.; Gomez Del Pulgar, T.; Valdes-Mora, F.; Cebrian, A.; Lacal, J.C.
Advances in Enzyme Regulation 51(1):183-94, 2011
Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation
Zhou, J.;Chehab, R.;Tkalcevic, J.;Naylor, M. J.;Harris, J.;Wilson, T. J.;Tsao, S.;Tellis, I.;Zavarsek, S.;Xu, D.;Lapinskas, E. J.;Visvader, J.;Lindeman, G. J.;Thomas, R.;Ormandy, C. J.;Hertzog, P. J.;Kola, I.;Pritchard, M. A. :
EMBO JOURNAL 24(3):635-44, 2005
Null mutation of the prolactin receptor gene produces a defect in maternal behavior
Lucas, B. K.;Ormandy, C. J.;Binart, N.;Bridges, R. S.;Kelly, P. A. :
ENDOCRINOLOGY 139(10):4102-7, 1998
Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development
Grimm, S. L.;Seagroves, T. N.;Kabotyanski, E. B.;Hovey, R. C.;Vonderhaar, B. K.;Lydon, J. P.;Miyoshi, K.;Hennighausen, L.;Ormandy, C. J.;Lee, A. V.;Stull, M. A.;Wood, T. L.;Rosen, J. M. :
MOLECULAR ENDOCRINOLOGY 16(12):2675-91, 2002
Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion
Young, A. I.; Timpson, P.; Gallego-Ortega, D.; Ormandy, C. J.; Oakes, S. R.
Cell Adhesion & Migration 12(6):513-523, 2018
Cell cycle proteins in epithelial cell differentiation: implications for breast cancer
Caldon, C.E., Sutherland, R.L.; Musgrove, E.A.
CELL CYCLE 9(10):1918-1928, 2010
Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue
Nilsson, L.;Binart, N.;Bohlooly, Y. M.;Bramnert, M.;Egecioglu, E.;Kindblom, J.;Kelly, P. A.;Kopchick, J. J.;Ormandy, C. J.;Ling, C.;Billig, H. :
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 331(4):1120-6, 2005
Osteoblasts are a new target for prolactin: analysis of bone formation in prolactin receptor knockout mice
Clement-Lacroix, P.;Ormandy, C.;Lepescheux, L.;Ammann, P.;Damotte, D.;Goffin, V.;Bouchard, B.;Amling, M.;Gaillard-Kelly, M.;Binart, N.;Baron, R.;Kelly, P. A. :
ENDOCRINOLOGY 140(1):96-105, 1999
Gata-3 and mammary cell fate
Naylor, M. J.;Ormandy, C. J. :
BREAST CANCER RES 9(2):302, 2007
Galanin and 11q13 amplification in human breast cancer
Ormandy, C. J.;Hui, R.;Sutherland, R. L. :
Biotech Lab Int Jul/Aug:14-16, 1998
Human growth hormone binds to lactogenic receptors in bovine, ovine and rat adrenals
Teh, L. C.;Ormandy, C. J.;Surus, A. S.;Sutherland, R. L.;Chapman, G. E. :
HORMONE AND METABOLIC RESEARCH 20(5):278-81, 1988
Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration
Binart, N.;Helloco, C.;Ormandy, C. J.;Barra, J.;Clement-Lacroix, P.;Baran, N.;Kelly, P. A. :
ENDOCRINOLOGY 141(7):2691-7, 2000
Mammary gland development
Ormandy, C. J.; Horseman, N. D.; Naylor, M.; Harris, J.; Robertson, F.; Binart, N.; Kelly, P. A.; Horseman, N. D.
Prolactin :pp219-232, 2001
Local insulin-like growth factor-II mediates prolactin-induced mammary gland development
Hovey, R. C.;Harris, J.;Hadsell, D. L.;Lee, A. V.;Ormandy, C. J.;Vonderhaar, B. K. :
MOLECULAR ENDOCRINOLOGY 17(3):460-71, 2003
Investigation of the transcriptional changes underlying functional defects in the mammary glands of prolactin receptor knockout mice
Ormandy, C. J.;Naylor, M.;Harris, J.;Robertson, F.;Horseman, N. D.;Lindeman, G. J.;Visvader, J.;Kelly, P. A. :
RECENT PROG HORM RES 58:297-323, 2003
Cyclin Dependent Kinase 2 inhibitors in cancer therapy: an update
Tadesse, S.; Caldon, E. C.; Tilley, W.; Wang, S.
JOURNAL OF MEDICINAL CHEMISTRY 62(9):4233-4251, 2019
Transcriptional changes underlying the secretory activation phase of mammary gland development
Naylor, M. J.;Oakes, S. R.;Gardiner-Garden, M.;Harris, J.;Blazek, K.;Ho, T. W.;Li, F. C.;Wynick, D.;Walker, A. M.;Ormandy, C. J. :
MOLECULAR ENDOCRINOLOGY 19(7):1868-83, 2005
Mouse prolactin receptor gene: genomic organization reveals alternative promoter usage and generation of isoforms via alternative 3'-exon splicing
Ormandy, C. J.;Binart, N.;Helloco, C.;Kelly, P. A. :
DNA AND CELL BIOLOGY 17(9):761-70, 1998