Cancer Biology

Selected Publications

Gallego-Ortega D, Oakes SR, and Ormandy CJ. Elf5 and breast cancer. Future Medicine Breast Cancer Management. 2013; 2:489-498

Lee, H.J., D. Gallego-Ortega, A. Ledger, D. Schramek, P. Joshi, M.M. Szwarc, C. Cho, J.P. Lydon, R. Khokha, J.M. Penninger, and C.J. Ormandy, Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development, 2013; 140(7):1397-1401.

Lee, H.J. and C.J. Ormandy, Elf5, hormones and cell fate. Trends in Endocrinology and Metabolism, 2012; 23(6):292-298.

Kalyuga, M., D. Gallego-Ortega, H.J. Lee, D.L. Roden, M.J. Cowley, C.E. Caldon, A. Stone, S.L. Allerdice, F. Valdes-Mora, R. Launchbury, A.L. Statham, N. Armstrong, M.C. Alles, A. Young, A. Egger, W. Au, C.L. Piggin, C.J. Evans, A. Ledger, T. Brummer, S.R. Oakes, W. Kaplan, J.M.W. Gee, R.I. Nicholson, R.L. Sutherland, A. Swarbrick, M.J. Naylor, S.J. Clark, J.S. Carroll, and C.J. Ormandy, ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer. Plos Biology, 2012; 10(12)

Lee, H.J., R.A. Hinshelwood, T. Bouras, D. Gallego-Ortega, F. Valdes-Mora, K. Blazek, J.E. Visvader, S.J. Clark, and C.J. Ormandy, Lineage Specific Methylation of the Elf5 Promoter in Mammary Epithelial Cells. Stem Cells, 2011; 29(10):1611-1619.

Alles, M.C., M. Gardiner-Garden, D.J. Nott, Y.X. Wang, J.A. Foekens, R.L. Sutherland, E.A. Musgrove, and C.J. Ormandy, Meta-Analysis and Gene Set Enrichment Relative to ER Status Reveal Elevated Activity of MYC and E2F in the "Basal" Breast Cancer Subgroup. Plos One, 2009; 4(3)

Oakes, S.R., M.J. Naylor, M.L. Asselin-Labat, K.D. Blazek, M. Gardiner-Garden, H.N. Hilton, M. Kazlauskas, M.A. Pritchard, L.A. Chodosh, P.L. Pfeffer, G.J. Lindeman, J.E. Visvader, and C.J. Ormandy, The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes & Development, 2008; 22(5):581-586.

Oakes, S.R., F.G. Robertson, J.G. Kench, M. Gardiner-Garden, M.P. Wand, J.E. Green, and C.J. Ormandy, Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions. Oncogene, 2007; 26(4):543-553

Harris, J., P.M. Stanford, K. Sutherland, S.R. Oakes, M.J. Naylor, F.G. Robertson, K.D. Blazek, M. Kazlauskas, H.N. Hilton, S. Wittlin, W.S. Alexander, G.J. Lindeman, J.E. Visvader, and C.J. Ormandy, Socs2 and Elf5 mediate prolactin-induced mammary gland development. Molecular Endocrinology, 2006. 20(5):1177-1187

Naylor, M.J., E. Ginsburg, T.P. Iismaa, B.K. Vonderhaar, D. Wynick, and C.J. Ormandy, The neuropeptide galanin augments lobuloalveolar development. Journal of Biological Chemistry, 2003; 278(31):29145-29152.

Brisken, C., S. Kaur, T.E. Chavarria, N. Binart, R.L. Sutherland, R.A. Weinberg, P.A. Kelly, and C.J. Ormandy, Prolactin controls mammary gland development via direct and indirect mechanisms. Developmental Biology, 1999; 210(1):96-106.

Ormandy, C.J., A. Camus, J. Barra, J.D. Damotte, B. Lucas, H. Buteau, M. Edery, N. Brousse, C. Babinet, N. Binart, and P.A. Kelly, Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes & Development, 1997; 11(2):167-178.


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