Cancer Cell Plasticity Lab

Selected Publications

  1. San Juan BP, Garcia-Leon MJ, Rangel L, Goetz JG, Chaffer CL. (2019) The Complexities of Metastasis. Cancers. Oct 16;11(10):1575
  2. Castaño Z, San Juan BP, Spiegel A, Pant A, DeCristo MJ, Laszewski T, Ubellacker JM, Janssen SR, Dongre A, Reinhardt F, Henderson A, Del Rio AG, Gifford AM, Herbert ZT, Hutchinson JN, Weinberg RA, Chaffer CL, McAllister SS. (2018) IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization. Nat Cell Biol. Sep;20(9):1084-1097
  3. Bierie B, Pierce SE, Kroeger C, Stover DG, Pattabiraman DR, Thiru P, Liu Donaher J, Reinhardt F, Chaffer CL, Keckesova Z, Weinberg RA. (2017) Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells. PNAS. Mar 21;114(12)
  4. Chaffer CL, San Juan BP, Lim E, Weinberg RA. (2016) EMT, cell plasticity and metastasis. Cancer Met Rev. 35(4):645-654
  5. Katajisto P, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic ND, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM. (2015) Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Science. 348(6232):340-3
  6. Chaffer CL, Marjanovic ND, Lee TI, Bell G, Kleer CG, Reinhardt F, D’Alessio AC, Young RA, Weinberg RA. (2013) Poised chromatin at the ZEB1 promoter enables cell plasticity and enhances tumorigenicity. Cell. 154(1):61-74
  7. Marjanovic ND, Weinberg RA, Chaffer CL. (2013). Poised with purpose: cell plasticity enhances tumorigenicity. Cell Cycle. 12(17):2713-4
  8. Scheel C, Ng Eaton E, Li SHJ, Chaffer CL, Reinhardt F, Kah KJ, Bell G, Guo W, Richardson AL, Weinberg RA. (2011) Formation and maintenance of mesenchymal and stem-cell states in the breast by paracrine and autocrine signals. Cell. 145(6):926-40
  9. Chaffer CL, and Weinberg RA. (2011). A perspective on cancer cell metastasis. Science. 331(6024):1559-64
  10. Chaffer CL, Brueckmann I, Scheel C, Kaestli AJ, Wiggins PA, Rodrigues LO, Reinhardt F, Su Y, Polyak K, Arendt LM, Kuperwasser C, Bierie B, Brooks M, Weinberg RA. (2011). Normal and neoplastic epithelial cells can spontaneously dedifferentiate to a stem-like state. PNAS. 108(19):7950-5
  11. Chaffer CL, Brennan JP, Slavin JL, Blick T, Thompson EW, Williams ED. (2006). Mesenchymal to epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Research. 66:11271-8

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