Our group is concerned with the identification of markers for therapeutic responsiveness, prognostic markers, and new markers of early prostate disease. We take a multidisciplinary approach that utilises expertise from a number of cancer researchers within and outside the Garvan, as well as clinicians and pathologists. Our research aims to identify genes and pathways whose expression changes can predict the development of aggressive life-threatening prostate cancer or resistance to chemotherapy used for the treatment of advanced stage prostate cancer.

Selected Publications

Mahon KL, Lin HM, Castillo L, Lee BY, Lee-Ng M, Chatfield MD, Chiam K, Breit SN, Brown DA, Molloy MP, Marx GM, Pavlakis N, Boyer MJ, Stockler MR, Daly RJ, Henshall SM, Horvath LG. Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer. Br J Cancer. 2015: 112 (8):1340-1348 

Lee BY, Timpson P, Horvath LG, Daly RJ. FAK signaling in human cancer as a target for therapeutics. Pharmacol Ther. 2015; 146:132-149 

Birch SE, Kench JG, Takano E, Chan P, Chan AL, Chiam K, Veillard AS, Stricker P, Haupt S, Haupt Y, Horvath L, Fox SB. Expression of E6AP and PML predicts for prostate cancer progression and cancer-specific death. Ann Oncol. 2014; 25(12):2392-2397

Galletti G, Matov A, Beltran H, Fontugne J, Miguel Mosquera J, Cheung C, MacDonald TY, Sung M, O'Toole S, Kench JG, Suk Chae S, Kimovski D, Tagawa ST, Nanus DM, Rubin MA, Horvath LG, Giannakakou P, Rickman DS. ERG induces taxane resistance in castration-resistant prostate cancer. Nat Commun. 2014; 5:5548

Mahon KL, Qu W, Devaney J, Paul C, Castillo L, Wykes RJ, Chatfield MD, Boyer MJ, Stockler MR, Marx G, Gurney H, Mallesara G, Molloy PL, Horvath LG, Clark SJ; PRIMe consortium. Methylated Glutathione S-transferase 1 (mGSTP1) is a potential plasma free DNA epigenetic marker of prognosis and response to chemotherapy in castrate-resistant prostate cancer. Br J Cancer. 2014; 111(9):1802-1809

Lin H-M, Castillo L, Mahon KL, Chiam K, Lee BY, Nguyen Q, Boyer MJ, Stockler MR, Pavlakis N, Marx G, Mallesara G, Gurney H, Clark SJ, Swarbrick A, Daly RJ and Horvath LG (2014). Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer. Br J Cancer 110:2462-2471.

Thompson JE, Moses D, Shnier R, Brenner P, Delprado W, Ponsky L, Pulbrook M, Böhm M, Haynes A-M, Hayen A and Stricker PD (2014). Multi-parametric magnetic resonance imaging guiding diagnostic biopsy detects significant prostate cancer, and could reduce unnecessary biopsies and over-detection: a prospective study. J Urol advance online publication 8 Feb 2014.

Lee BY, Hochgrafe F, Lin HM, Castillo L, Wu J, Raftery M, Shreeve SM, Horvath LG and Daly RJ (2014). Phosphoproteomic profiling identifies focal adhesion kinase as a mediator of docetaxel resistance in castrate-resistant prostate cancer. Mol Cancer Ther 13: 190-201.

Thompson JE, Egger S, Böhm M, Haynes A-M, Matthews J, Rasiah K and Stricker PD (2014). Superior quality of life and improved surgical margins are achievable with robotic radical prostatectomy after a long learning curve: a prospective single-surgeon study of 1552 consecutive cases. Eur Urol 65:521-531.

Savdie R, Horvath LG, Pe Benito R, Rasiah KK, Haynes A-M, Chatfield M, Stricker PD, Turner JJ, Delprado W, Henshall SM, Sutherland RL and Kench JG (2012). High Gleason grade carcinoma at a positive surgical margin predicts biochemical failure after radical prostatectomy and may guide adjuvant radiotherapy. BJU Int 109: 1794-800.

More Garvan Publications

Staff in the Group

Quoc Nguyen

Administrative Director - APCRC-NSW

Anne-Maree Haynes

Biobank/Data Manager Prostate Group

Anaiis Zaratzian

Histopathology & Biospecimen Manager

Thomas Cusick

Research Assistant

Prof James Kench

Visiting Scientist

Dr Kate Mahon

Visiting PhD student

Dr Maret Boehm

Clinical Data Manager

Michael Tayao

Laboratory Technician

Andrew Da Silva

Histology Technician

Dr Krishan Rasiah

Visiting Urology Scientist

Judith Grogan

Visiting Pathologist

Louise Emmett

Honorary Nuclear Medicine Specialist

Matthys Scheltema

Research Fellow

Blossom Mak

Visiting Student

Rohan Nandurkar

Medical Student

Natasha Masand

Research Assistant

Nicole Yeung

Research Assistant

Leeda Zamiri

Blood Processing Technician

James Symons

VMO Urologist

Dr Alexander Blazevski

Urology Research Fellow

Dr Brian Yuen

Visiting Urology Fellow

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