Dr Hui-Ming Lin

Research Officer

Hui-Ming completed her PhD degree at the University of Auckland in 2010. Her PhD thesis was about the metabolomic analysis of the interleukin-10 knockout mouse model of inflammatory bowel disease.

Prior to her PhD studies, she was an Assistant Research Fellow in the Cancer Genetics Laboratory, University of Otago, New Zealand, from 2004-2006.

Her current research at the Garvan Institute focuses on identifying therapeutic response biomarkers and elucidating the mechanisms of chemotherapy resistance in metastatic prostate cancer.

Research Interests

biomarker discovery
predicting and improving therapeutic response in prostate cancer
role of microRNAs in therapeutic response


2010 - PhD (Molecular Medicine), University of Auckland, New Zealand
2003 - MSc (Biochemistry), University of Canterbury, New Zealand
2000 - BSc (Biochemistry), University of Canterbury, New Zealand

Selected Publications

Mahon KL, Lin HM, Castillo L, Lee BY, Lee-Ng M, Chatfield MD, Chiam K, Breit SN, Brown DA, Molloy MP, Marx GM, Pavlakis N, Boyer MJ, Stockler MR, Daly RJ, Henshall SM, Horvath LG. Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer. Br J Cancer. 2015; 112 (8):1340-1348 

Lin H-M, Castillo L, Mahon KL, Chiam K, Lee BY, Nguyen Q, Boyer MJ, Pavlakis N, Marx G, Mallesara G, Gurney H, Clark SJ, Swarbrick A, Daly RJ, Horvath LG. Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer. Br J Cancer. 2014; 110(10):2462-2471

Lee BY, Hochgrafe F, Lin H-M, Castillo L, Wu J, Raftery MJ, Shreeve SM, Horvath LG, Daly RJ. Phosphoproteomic profiling identifies focal adhesion kinase as a mediator of docetaxel resistance in castrate-resistant prostate cancer. Mol Cancer Ther. 2014;13(1):190-201

Lin H-M and Rowan D. Metabolomics: An important tool for assessing state of health and risk of disease in nutrigenomics research. In Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition. Ferguson L (ed) CRC Press. 2013;p229-242

Lin H-M, Edmunds S, Zhu S, Helsby N, Ferguson LR, Rowan D. Metabolomic analysis reveals differences in urinary excretion of kiwifruit-derived metabolites in a mouse model of inflammatory bowel disease. Mol Nutr Food Res 2011;55(12):1900-1904

Otter D, Cao M, Lin H-M, Fraser K, Edmunds S, Lane G, Rowan D . Identification of urinary biomarkers of colon inflammation in IL10-/- mice using short-column LCMS metabolomics. J Biomed Biotechnol. 2011;2011:974701

Lin H-M, Rowan DD, Helsby NA, Ferguson LR. Using metabolomic analysis to understand inflammatory bowel diseases. Inflamm Bowel Dis. 2010;17(4):1021-1029

Lin H-M, Barnett MP, Roy NC, Joyce NI, Zhu S, Armstrong K, Helsby NA, Ferguson LR, Rowan DD. Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn’s disease. J Proteome Res. 2010;9(4):1965-1975

Lin H-M, Edmunds SJ, Helsby NA, Ferguson LR, Rowan DD. Non-targeted urinary metabolite profiling of a mouse model of Crohn’s disease. J Proteome Res. 2009;8(4):2045-2057

Dr Hui-Ming Lin