Dr Dominique Hess

Dominique Hess (Gatto) received her PhD from the Swiss Federal Institute of Technology in Zurich in 2005 and subsequently joined the Garvan Institute to undertake post-doctoral studies. Her doctoral and post-doctoral research focused on the regulation of antibody responses and led to the discovery o
Manager, Genomic Cancer Medicine

Group Leader

Conjoint/Adjunct Role(s)

Conjoint Senior Lecturer, St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney

Dominique Hess (Gatto) received her PhD from the Swiss Federal Institute of Technology in Zurich in 2005 and subsequently joined the Garvan Institute to undertake post-doctoral studies. Her doctoral and post-doctoral research focused on the regulation of antibody responses and led to the discovery of a novel receptor guiding leukocyte migration.

In her current role as Program Manager within the Genomic Cancer Medicine Program, Dominique coordinates the Molecular Screening and Therapeutics (MoST) Program, a research program that uses genomic information to identify new therapeutic opportunities for patients with advanced rare or neglected cancers.  

Her main research interest is the clinical development of precision immunotherapy approaches for tailoring treatment with immunotherapy to individual patients.

Research Interests

Precision Oncology
Cancer Immunotherapy
Rare Cancers
Clinical Trials

Awards and Honours

2014-2018 - NHMRC Career Development Fellowship
2011-2013 - NHMRC Project Grant
2009 - US Alliance for Lupus Research Pilot grant
2008-2011 - NHMRC Early Career Fellowship
2005 - Swiss Federal Institute of Technology Medal of Distinction for PhD Thesis

Education

2005 - PhD, Swiss Federal Institute of Technology, Zurich - Switzerland
2000 - MSc, Swiss Federal Institute of Technology, Zurich - Switzerland

Selected Publications

Gatto, D., Wood, K., Caminschi, I., Murphy-Durland, D., Schofield, P., Christ, D., Karupiah, G. & Brink, R. The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells. Nat. Immunol. 2013; 14:446-453.

Gatto, D. & Brink, R. B cell localization: regulation by EBI2 and its oxysterol ligand. Trends Immunol. 2013; 34:336-342.

Gatto, D., Wood, K. & Brink, R. EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center. J. Immunol. 2011; 187:4621-4628.

Gatto, D. & Brink, R. The germinal center reaction. J. Allergy. Clin. Immunol. 2010; 126:898-907.

Gatto, D., Paus, D., Basten, A., Mackay, C.R. & Brink, R. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 2009; 31:259-269.

Chan, T.D., Gatto, D., Wood, K., Camidge, T., Basten, A. & Brink, R. Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts. J. Immunol. 2009; 183:3139-3149.

Gatto, D., Martin, S.W., Bessa, J., Pellicioli, E., Saudan, P., Hinton, H.J. & Bachmann, M.F. Regulation of memory antibody levels: the role of persisting antigen versus plasma cell life span. J. Immunol. 2007; 178:67-76.

Gatto, D., Pfister, T., Jegerlehner, A., Martin, S.W., Kopf, M. & Bachmann, M.F. Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1. J. Exp. Med. 2005; 201:993-1005.

Gatto, D. & Bachmann, M.F. Function of marginal zone B cells in antiviral B-cell responses. Crit. Rev. Immunol. 2005; 25:331-342.

Gatto, D., Ruedl, C., Odermatt, B. & Bachmann, M.F. Rapid response of marginal zone B cells to viral particles. J. Immunol. 2004; 173:4308-4316.

Macpherson, A.J., Gatto, D., Sainsbury, E., Harriman, G.R., Hengartner, H. & Zinkernagel, R.M. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 2000; 288:2222-2226.

Person portrait

Dr Dominique Hess