Dr David Herrmann

Senior Research Officer

I completed my Diploma and PhD studies in the field of Developmental Biology in Freiburg, Germany. Due to the strong similarities between embryonic development and cancerogenesis I became interested in joining Dr Paul Timpson’s research group to work on invasion and metastasis, moving to Sydney to join the Garvan Institute in 2012.

Research Interests

Cell migration and motility
Signaling and biosensor read-outs

Awards and Honours

2016 - Young Garvan Finalist:
2010 - Traveling grant from the CDB Riken Center, Japan to attend the meeting “Frontiers in Organogenesis”, Kobe
2009 - Member of the GRK1104 “From Cells to Organs: Molecular Mechanisms of Organogenesis”
2008 - Alumni-Diploma Award, University of Freiburg, Faculty of Biology


2012 - PhD, Albert-Ludwigs-University, Freiburg - Germany
2007 - Diploma, Albert-Ludwigs-University, Freiburg - Germany

Selected Publications

Vennin C, Chin VT, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec P, Walters SN, del Monte-Nieto G, Conway JRW, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam ASA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NLE, Phan T, Jain R, Weninger W,  McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP,  Biankin AV, Australian Pancreatic Cancer Genome Initiative, Evans J, Anderson KI, Grey ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M and Timpson P (2017) Transient tissue ‘priming’ via ROCK manipulation uncouples pancreatic cancer progression, chemo-resistance and the onset of the metastatic niche. Science Translational Medicine, 9(384). doi: 10.1126/scitranslmed.aai8504.

Harris NLE, Vennin C, Conway JRW, Vine KL, Pinese M, Cowley MJ, Shearer RF, Lucas MC, Herrmann D, Allam AH, Pajic M, Morton JP, Australian Pancreatic Cancer Genome Initiative, Biankin AV, Ranson M, Timpson P and Saunders DN (2017) SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer. Oncogene, Mar 27. doi: 10.1038/onc.2017.63.

Herrmann D, Vennin C, Lucas MC, Timpson P.  Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression. F1000Research 2016;5(F1000 Faculty Rev):892

Herrmann D, Erami Z et al. Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue. Cell Rep 2016;14, 152-67.

Gallego-Ortega D, Ledger A, Roden DL, Law AM, Magenau A, Kikhtyak Z, Cho C, Allerdice SL, Lee HJ, Valdes-Mora F, Herrmann D, Salomon R, Young AI, Lee BY, Sergio CM, Kaplan W, Piggin C, Conway JR, Rabinovich B, Millar EK, Oakes SR, Chtanova T, Swarbrick A Naylor MJ, O'Toole S, Green AR, Timpson P, Gee JM, Ellis IO, Clark SJ, Ormandy CJELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells. PLoS Biol 2015;Dec 30;13(12)

Pajic M, Herrmann D, Vennin C, Conway JR, Chin VT, Johnsson AK, Welch HC, Timpson P. The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment. Small GTPases 2015;6(2):123-33

Belle L, Ali N, Lonic A, Li X, Paltridge JL, Roslan S, Herrmann D, Conway JR, Gehling FK, Bert AG, Crocker LA, Tsykin A, Farshid G, Goodall GJ, Timpson P, Daly RJ, Khew-Goodall Y. The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking. Sci Signal 2015 Feb 17;8(364).

Nobis M, McGhee EJ, Herrmann D, Magenau A, Morton JP, Anderson KI, Timpson P. Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging. Cell Adhesion & Migration 2014;8(5).

Herrmann D, Conway JRW, Vennin C, Magenau A, Hughes WE, Morton JP and Timpson P. Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment. Carcinogenesis 2014 Aug;35(8):1671-9.

Herrmann D, Ferrer-Vaquer A, Lahsnig C, Firnberg N, Leibbrandt A, Neubüser A. Expression and Regulation of ANTXR1 in the Chick Embryo. Dev Dyn. 2010;239(2):680-7

Fuchs A, Inthal A, Herrmann D, Cheng S, Nakatomi M, Peters H, Neubüser A. Regulation of Tbx22 during facial and palatal development. Dev Dyn. 2010;239(11):2860-74.

Dr David Herrmann