Dr Sean Warren
After graduating from the University of Cambridge in Experimental Physics I moved to London to start an interdisciplinary PhD in Prof Paul French’s group at Imperial College London. My PhD project was a collaboration with the Katan lab at the Institute of Cancer Research and involved developing microscopy techniques to image the activation of multiple proteins in live cells during chemotaxis.
My project involved developing tools for fluorescence lifetime imaging (FLIM) and polarisation-resolved imaging. After my PhD I joined Dr Paul Timpson’s Lab to develop these techniques and apply them in an in-vivo context to study invasion and metastasis.
In the NewsAnnual awards celebrate key Garvan researchers - May 09, 2017
2010 - MRes, Imperial College London - UK
2008 - MSci, University of Cambridge - UK
Vennin C, Chin VT, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec P, Walters SN, del Monte-Nieto G, Conway JRW, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam ASA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NLE, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV, Australian Pancreatic Cancer Genome Initiative, Evans J, Anderson KI, Grey ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M and Timpson P (2017) . Science Translational Medicine, 9(384). doi: 10.1126/scitranslmed.aai8504.
Conway JRW, Warren SC and Timpson P (2017) Context-dependent intravital imaging of therapeutic response using intramolecular FRET biosensors. Methods doi: 10.1016/j.ymeth.2017.04.014.
Erami Z, Herrmann D, Warren SC, Nobis M, McGhee EJ, Lucas MC, Leung W, Reischmann N, Mrowinska A, Schwarz JP, Kadir S, Conway, JRW, Vennin C, Karim SA, Campbell AD, Gallego-Ortega D, Magenau A, Murphy KJ, Ridgway RA, Law AM, Walters SN, Grey ST, Croucher DR, Zhang L, Herzog H, Hardeman EC, Gunning PW, Ormandy CJ, T.R. Evans J, Strathdee D, Sansom OJ, Morton JP, Anderson KI and Timpson P (2016) Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue, Cell reports 14, 152-167.
Warren SC, Margineanu A, Katan M, Dunsby C, French PM, Homo-FRET Based Biosensors and Their Application to Multiplexed Imaging of Signalling Events in Live Cells. International Journal of Molecular Sciences 16 (7), 14695-14716
Sherlock B, Warren SC, Stone J, Neil M, Paterson C, Knight J, French PM, Dunsby C. Fibre-coupled multiphoton microscope with adaptive motion compensation. Biomedical Optics Express 6 (5), 1876-1884
Sparks H, Warren SC, Guedes J, Yoshida N, Charn TC, Guerra N, Tatla T, Dunsby C French, PM. A flexible wide-field FLIM endoscope utilising blue excitation light for label-free contrast of tissue. Journal of Biophotonics. 2014, 10.1002/jbio.201300203
Warren SC, Margineanu A, Alibhai D, Kelly DJ, Talbot CB, Alexandrov Y, Munro I, Katan, M, Dunsby, C, French PM. Rapid global fitting of large fluorescence lifetime imaging microscopy datasets. PLoS ONE. 2013, 8(8): e70687
Martins M, Warren SC, Kimberley C, Margineanu A, Peschard P, McCarthy A, Yeo M, Marshall CJ, Dunsby C, French PM, Katan M. Activity of phospholipase C epsilon contributes to chemotaxis of fibroblasts towards platelet-derived growth factor. Journal of Cell Science. 2012, 125(23): 5758–5769.