Network Biology Lab

Network Biology Lab

NETWORK BIOLOGY

The Network Biology research group focuses on combining computational approaches with novel proteomics (Croucher et al., Science Signaling, 2016) and single-cell technologies to understand how altered signalling pathway dynamics can lead to tumour progression and therapeutic resistance. We use these advances to develop patient-specific simulations of drug response as clinically-relevant biomarkers (Fey et al., Science Signaling, 2015), dissect non-intuitive mechanisms of drug resistance (Kennedy et al., Breast Cancer Research, 2019; Marini et al., Science Translational Medicine, 2018) and develop rationalised strategies to target pleiotropic signalling pathways.