Network Biology Lab

Publications

Applications of personalised signalling network models in precision oncology
Hastings, J. F.; O'Donnell, Y. E. I.; Fey, D.; Croucher, D. R.
PHARMACOLOGY & THERAPEUTICS 212:107555, 2020
A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers
Filipcik, P.; Latham, S. L.; Cadell, A. L.; Day, C. L.; Croucher, D. R.; Mace, P. D.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117(35):21308-21318, 2020
Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases
Trevelyan, S. J.; Brewster, J. L.; Burgess, A. E.; Crowther, J. M.; Cadell, A. L.; Parker, B. L.; Croucher, D. R.; Dobson, R. C. J.; Murphy, J. M.; Mace, P. D.
Science Signaling 13(622) 2020
Histone deacetylases and histone deacetylase inhibitors in neuroblastoma
Phimmachanh, M.; Han, J. Z. R.; O'Donnell, Y. E. I.; Latham, S. L.; Croucher, D. R.
Front Cell Dev Biol 8:578770, 2020
A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells
Croucher, D. R.;Saunders, D. N.;Stillfried, G. E.;Ranson, M. :
BIOCHEMICAL JOURNAL 408(2):203-10, 2007
Myosin XVIII
Taft, M. H.; Latham, S. L.
Advances in Experimental Medicine and Biology 1239:421-438, 2020
Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients.
Fey, D.; Halasz, M.; Dreidax, D.; Kennedy, S.P.; Hastings, J.; Rauch, N.; Garcia Munoz, A.; Pilkington, R.; Fischer, M.; Westermann, F.; Kolch, W.; Kholodenko, B.N.; Croucher, D.R.;
SCIENCE SIGNALLING 8(408):ra130, 2015
Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma
Hastings, J. F.; Gonzalez Rajal, A.; Latham, S. L.; Han, J. Z.; McCloy, R. A.; O'Donnell, Y. E.; Phimmachanh, M.; Murphy, A. D.; Nagrial, A.; Daneshvar, D.; Chin, V.; Watkins, D. N.; Burgess, A.; Croucher, D. R.
eLife 9:e53367, 2020
Dissecting multi-protein signaling complexes by Bimolecular Complementation Affinity Purification (BiCAP)
Hastings, J. F.; Han, J. Z. R.; Shearer, R. F.; Kennedy, S. P.; Iconomou, M.; Saunders, D. N.; Croucher, D. R.
Jove-Journal of Visualized Experiments (136):e57109, 2018
Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma
Gonzalez-Rajal, A.; Hastings, J. F.; Watkins, D. N.; Croucher, D. R.; Burgess, A.
Frontiers in Cell and Developmental Biology 8:305, 2020
Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
Kennedy, S. P.; Han, J. Z. R.; Portman, N.; Nobis, M.; Hastings, J. F.; Murphy, K. J.; Latham, S. L.; Cadell, A. L.; Miladinovic, D.; Marriott, G. R.; O'Donnell, Y. E. I.; Shearer, R. F.; Williams, J. T.; Munoz, A. G.; Cox, T. R.; Watkins, D. N.; Saunders, D. N.; Timpson, P.; Lim, E.; Kolch, W.; Croucher, D. R.
BREAST CANCER RESEARCH 21(1):43, 2019
Myosin-18B regulates higher-order organization of the cardiac sarcomere through thin filament cross-linking and thick filament dynamics
Latham, S. L.; Weiss, N.; Schwanke, K.; Thiel, C.; Croucher, D. R.; Zweigerdt, R.; Manstein, D. J.; Taft, M. H.
Cell Reports 32(9):108090, 2020