Tumour Progression Lab

Publications

Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications
McCart Reed, A. E.; Kalaw, E.; Nones, K.; Bettington, M.; Lim, M.; Bennett, J.; Johnstone, K.; Kutasovic, J. R.; Saunus, J. M.; Kazakoff, S.; Xu, Q.; Wood, S.; Holmes, O.; Leonard, C.; Reid, L. E.; Black, D.; Niland, C.; Ferguson, K.; Gresshoff, I.; Raghavendra, A.; Harvey, K.; Cooper, C.; Liu, C.; Kalinowski, L.; Reid, A. S.; Davidson, M.; Pearson, J. V.; Pathmanathan, N.; Tse, G.; Papadimos, D.; Pathmanathan, R.; Harris, G.; Yamaguchi, R.; Tan, P. H.; Fox, S.; O'Toole, S. A.; Simpson, P. T.; Waddell, N.; Lakhani, S. R.
JOURNAL OF PATHOLOGY 247(2):214-227, 2019
Screening for ROS1 gene rearrangements in non-small-cell lung cancers using immunohistochemistry with FISH confirmation is an effective method to identify this rare target
Selinger, C. I.; Li, B. T.; Pavlakis, N.; Links, M.; Gill, A. J.; Lee, A.; Clarke, S.; Tran, T. N.; Lum, T.; Yip, P. Y.; Horvath, L.; Yu, B.; Kohonen-Corish, M. R.; O'Toole, S. A.; Cooper, W. A.
HISTOPATHOLOGY 70(3):402-411, 2017
The hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy
Hui, M.; Cazet, A.; Nair, R.; Watkins, D.N.; O'Toole, S.; Swarbrick, A.;
BREAST CANCER RES 15(2):203, 2013
Proteomic Analysis of Urine to Identify Breast Cancer Biomarker Candidates Using a Label-Free LC-MS/MS Approach
Beretov, J.
; Wasinger, V. C.
; Millar, E. K.
; Schwartz, P.
; Graham, P. H.
; Li, Y.;
PLoS One 10(11):e0141876, 2015
Cytoplasmic localization of B-catenin is a marker of a poor outcome in breast cancer patients
Lopez-Knowles, E., Zardawi, S.J., McNeil, C.M., Millar, E.K.A., Crea, P., Musgrove, E.A., Sutherland, R.L.; O'Toole, S.A.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 19(1):301-309, 2010
Optimise not compromise: The importance of a multidisciplinary breast cancer patient pathway in the era of oncoplastic and reconstructive surgery
Strach, M. C.; Prasanna, T.; Kirova, Y. M.; Alran, S.; O'Toole, S.; Beith, J. M.; Poortmans, P.; McNeil, C. M.; Carroll, S.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY 134:10-21, 2019
Therapeutic targets in triple negative breast cancer
O'Toole, S.; Beith, M.J.; Millar, E.K.; West, R.; McLean, A.; Cazet, A.; Swarbrick, A.; Oakes, S.R;
JOURNAL OF CLINICAL PATHOLOGY :10.1136/jclinpath-2012-201361, 2013
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma
Swarbrick, A.; Woods, S. L.; Shaw, A.; Balakrishnan, A.; Phua, Y.; Nguyen, A.; Chanthery, Y.; Lim, L.; Ashton, L. J.; Judson, R. L.; Huskey, N.; Blelloch, R.; Haber, M.; Norris, M. D.; Lengyel, P.; Hackett, C. S.; Preiss, T.; Chetcuti, A.; Sullivan, C. S.; Marcusson, E. G.; Weiss, W.; L'Etoile, N.; Goga, A.;
NATURE MEDICINE 16(10):1134-40, 2010
MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene
Phua, Y. W.; Nguyen, A.; Roden, D. L.; Elsworth, B.; Deng, N.; Nikolic, I.; Yang, J.; McFarland, A.; Russell, R.; Kaplan, W.; Cowley, M. J.; Nair, R.; Zotenko, E.; O'Toole, S.; Tan, S. X.; James, D. E.; Clark, S. J.; Kouros-Mehr, H.; Swarbrick, A.;
BREAST CANCER RES 17:83, 2015
Fluorescent in situ hybridization in surgical pathology practice
Gupta, R.; Cooper, W. A.; Selinger, C.; Mahar, A.; Anderson, L.; Buckland, M. E.; O'Toole, S. A.
Advances in Anatomic Pathology 25(4):223-237, 2018
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors
Hendry, S.; Salgado, R.; Gevaert, T.; Russell, P. A.; John, T.; Thapa, B.; Christie, M.; van de Vijver, K.; Estrada, M. V.; Gonzalez-Ericsson, P. I.; Sanders, M.; Solomon, B.; Solinas, C.; Van den Eynden, Gggm; Allory, Y.; Preusser, M.; Hainfellner, J.; Pruneri, G.; Vingiani, A.; Demaria, S.; Symmans, F.; Nuciforo, P.; Comerma, L.; Thompson, E. A.; Lakhani, S.; Kim, S. R.; Schnitt, S.; Colpaert, C.; Sotiriou, C.; Scherer, S. J.; Ignatiadis, M.; Badve, S.; Pierce, R. H.; Viale, G.; Sirtaine, N.; Penault-Llorca, F.; Sugie, T.; Fineberg, S.; Paik, S.; Srinivasan, A.; Richardson, A.; Wang, Y.; Chmielik, E.; Brock, J.; Johnson, D. B.; Balko, J.; Wienert, S.; Bossuyt, V.; Michiels, S.; Ternes, N.; Burchardi, N.; Luen, S. J.; Savas, P.; Klauschen, F.; Watson, P. H.; Nelson, B. H.; Criscitiello, C.; O'Toole, S.; Larsimont, D.; de Wind, R.; Curigliano, G.; Andre, F.; Lacroix-Triki, M.; van de Vijver, M.; Rojo, F.; Floris, G.; Bedri, S.; Sparano, J.; Rimm, D.; Nielsen, T.; Kos, Z.; Hewitt, S.; Singh, B.; Farshid, G.; Loibl, S.; Allison, K. H.; Tung, N.; Adams, S.; Willard-Gallo, K.; Horlings, H. M.; Gandhi, L.; Moreira, A.; Hirsch, F.; Dieci, M. V.; Urbanowicz, M.; Brcic, I.; Korski, K.; Gaire, F.; Koeppen, H.; Lo, A.; Giltnane, J.; Rebelatto, M. C.; Steele, K. E.; Zha, J.; Emancipator, K.; Juco, J. W.; Denkert, C.; Reis-Filho, J.; Loi, S.; Fox, S. B.
Advances in Anatomic Pathology 24(6):311-335, 2017
Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome
Millar, E. K.; Dean, J. L.; McNeil, C. M.; O'Toole, S. A.; Henshall, S. M.; Tran, T.; Lin, J.; Quong, A.; Comstock, C. E.; Witkiewicz, A.; Musgrove, E. A.; Rui, H.; Lemarchand, L.; Setiawan, V. W.; Haiman, C. A.; Knudsen, K. E.; Sutherland, R. L.; Knudsen, E. S.;
ONCOGENE 28(15):1812-20, 2009
Massive parallel sequencing of solid tumours - challenges and opportunities for pathologists
Harris, G.; O'Toole, S.; George, P.; Browett, P.; Print, C.
HISTOPATHOLOGY 70(1):123-133, 2017
Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma
Zilberg, C.; Lee, M. W.; Yu, B.; Ashford, B.; Kraitsek, S.; Ranson, M.; Shannon, K.; Cowley, M.; Iyer, N. G.; Palme, C. E.; Ch'ng, S.; Low, T. H.; O'Toole, S.; Clark, J. R.; Gupta, R.
MODERN PATHOLOGY 31(2):275-287, 2018
The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma
Coulson, R.; Liew, S. H.; Connelly, A. A.; Yee, N. S.; Deb, S.; Kumar, B.; Vargas, A. C.; O'Toole, S. A.; Parslow, A. C.; Poh, A.; Putoczki, T.; Morrow, R. J.; Alorro, M.; Lazarus, K. A.; Yeap, E. F. W.; Walton, K. L.; Harrison, C. A.; Hannan, N. J.; George, A. J.; Clyne, C. D.; Ernst, M.; Allen, A. M.; Chand, A. L.
Oncotarget 8(12):18640-18656, 2017
Prediction of outcome of early ER+ breast cancer is improved using a biomarker panel, which includes Ki-67 and p53.
Millar, E. K.; Graham, P. H.; McNeil, C. M.; Browne, L.; O'Toole, S. A.; Boulghourjian, A.; Kearsley, J. H.; Papadatos, G.; Delaney, G.; Fox, C.; Nasser, E.; Capp, A.; Sutherland, R. L.;
British Journal of Cancer 105(2):272-80, 2011
Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion
Duivenvoorden, H. M.; Rautela, J.; Edgington-Mitchell, L. E.; Spurling, A.; Greening, D. W.; Nowell, C. J.; Molloy, T. J.; Robbins, E.; Brockwell, N. K.; Lee, C. S.; Chen, M.; Holliday, A.; Selinger, C. I.; Hu, M.; Britt, K. L.; Stroud, D. A.; Bogyo, M.; Moller, A.; Polyak, K.; Sloane, B. F.; O'Toole, S. A.; Parker, B. S.
JOURNAL OF PATHOLOGY 243(4):496-509, 2017
Extramedullary haematopoiesis in axillary lymph nodes following neoadjuvant chemotherapy for locally advanced breast cancer?a potential diagnostic pitfall.
Millar, E.K.A.; Inder, S.; Lynch, J.
HISTOPATHOLOGY 54(5):622-3, 2009
Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer
O'Toole, S. A.; Machalek, D. A.; Shearer, R. F.; Millar, E. K.; Nair, R.; Schofield, P.; McLeod, D.; Cooper, C. L.; McNeil, C. M.; McFarland, A.; Nguyen, A.; Ormandy, C. J.; Qiu, M. R.; Rabinovich, B.; Martelotto, L. G.; Vu, D.; Hannigan, G. E.; Musgrove, E. A.; Christ, D.; Sutherland, R. L.; Watkins, D. N.; Swarbrick, A.;
CANCER RESEARCH 71(11):4002-4014, 2011
Equivocal ALK fluorescence in-situ hybridization (FISH) cases may benefit from ancillary ALK FISH probe testing
Selinger, C.; Cooper, W.; Lum, T.; McNeil, C.; Morey, A.; Waring, P.; Amanuel, B.; Millward, M.; Peverall, J.; Van Vliet, C.; Christie, M.; Tran, Y.; Diakos, C.; Pavlakis, N.; Gill, A. J.; O'Toole, S.
HISTOPATHOLOGY 67:654-663, 2015
Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer
Pang, J. B.; Savas, P.; Fellowes, A. P.; Mir Arnau, G.; Kader, T.; Vedururu, R.; Hewitt, C.; Takano, E. A.; Byrne, D. J.; Choong, D. Y.; Millar, E. K.; Lee, C. S.; O'Toole, S. A.; Lakhani, S. R.; Cummings, M. C.; Mann, G. B.; Campbell, I. G.; Dobrovic, A.; Loi, S.; Gorringe, K. L.; Fox, S. B.
MODERN PATHOLOGY 30(7):952-963, 2017
Assessing tumor-infiltrating lymphocytes in solid tumors: A practical review for pathologists and proposal for a standardized method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the host immune response, TILs in invasive breast carcinoma and ductal carcinoma in situ, metastatic tumor deposits and areas for further research
Hendry, S.; Salgado, R.; Gevaert, T.; Russell, P. A.; John, T.; Thapa, B.; Christie, M.; van de Vijver, K.; Estrada, M. V.; Gonzalez-Ericsson, P. I.; Sanders, M.; Solomon, B.; Solinas, C.; Van den Eynden, Gggm; Allory, Y.; Preusser, M.; Hainfellner, J.; Pruneri, G.; Vingiani, A.; Demaria, S.; Symmans, F.; Nuciforo, P.; Comerma, L.; Thompson, E. A.; Lakhani, S.; Kim, S. R.; Schnitt, S.; Colpaert, C.; Sotiriou, C.; Scherer, S. J.; Ignatiadis, M.; Badve, S.; Pierce, R. H.; Viale, G.; Sirtaine, N.; Penault-Llorca, F.; Sugie, T.; Fineberg, S.; Paik, S.; Srinivasan, A.; Richardson, A.; Wang, Y.; Chmielik, E.; Brock, J.; Johnson, D. B.; Balko, J.; Wienert, S.; Bossuyt, V.; Michiels, S.; Ternes, N.; Burchardi, N.; Luen, S. J.; Savas, P.; Klauschen, F.; Watson, P. H.; Nelson, B. H.; Criscitiello, C.; O'Toole, S.; Larsimont, D.; de Wind, R.; Curigliano, G.; Andre, F.; Lacroix-Triki, M.; van de Vijver, M.; Rojo, F.; Floris, G.; Bedri, S.; Sparano, J.; Rimm, D.; Nielsen, T.; Kos, Z.; Hewitt, S.; Singh, B.; Farshid, G.; Loibl, S.; Allison, K. H.; Tung, N.; Adams, S.; Willard-Gallo, K.; Horlings, H. M.; Gandhi, L.; Moreira, A.; Hirsch, F.; Dieci, M. V.; Urbanowicz, M.; Brcic, I.; Korski, K.; Gaire, F.; Koeppen, H.; Lo, A.; Giltnane, J.; Rebelatto, M. C.; Steele, K. E.; Zha, J.; Emancipator, K.; Juco, J. W.; Denkert, C.; Reis-Filho, J.; Loi, S.; Fox, S. B.
Advances in Anatomic Pathology 24(5):235-251, 2017
LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness
Pang, J. B.; Molania, R.; Chand, A.; Knower, K.; Takano, E. A.; Byrne, D. J.; Mikeska, T.; Millar, E. K. A.; Lee, C. S.; O'Toole, S. A.; Clyne, C.; Gorringe, K. L.; Dobrovic, A.; Fox, S. B.
Oncotarget 8(48):83626-83636, 2017
Molecular assays in breast cancer pathology.
O'Toole, S.A.; Selinger, T.; Millar, E.K.A.; Lum, T.; Beith, J.M.
PATHOLOGY 43(2):116-27, 2011
MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells
Plummer, P.; Freeman, R.; Taft, R.; Vider, J.; Sax, M.; Umer, B.A.; Gao, D.; Johns, C.; Mattick, J.S.; Wilton, S.D.; Ferro, V.; McMillan, N.A.J.; Swarbrick, A.; Mittal, V.; Mellick, A.S.;
CANCER RESEARCH 73(1):341-52, 2013
Prediction of local recurrence, distant metastases and death following breast-conserving therapy in early-stage invasive breast cancer using a five biomarker panel.
Millar, E.K.A.; Graham, P.H.; O'Toole, S.A.; McNeil, C.M.; Browne, L.; Morey, A.L.; Eggleton, S.; Beretov, J.; Theocharous, C.; Capp, A.; Nasser, E.; Kearsley, J.H.; Delaney, G.; Papadatos, G.; Fox, C.; Sutherland, R.L.
JOURNAL OF CLINICAL ONCOLOGY 27(28):4701-4708, 2009
Somatic mutations in salivary duct carcinoma and potential therapeutic targets
Khoo, T. K.; Yu, B.; Smith, J. A.; Clarke, A. J.; Luk, P. P.; Selinger, C. I.; Mahon, K. L.; Kraitsek, S.; Palme, C.; Boyer, M. J.; Dinger, M. E.; Cowley, M. J.; O'Toole, S. A.; Clark, J. R.; Gupta, R.
Oncotarget 8(44):75893-75903, 2017
Tumor PIK3CA genotype and prognosis in early-stage breast cancer: a pooled analysis of individual patient data
Zardavas, D.; Te Marvelde, L.; Milne, R. L.; Fumagalli, D.; Fountzilas, G.; Kotoula, V.; Razis, E.; Papaxoinis, G.; Joensuu, H.; Moynahan, M. E.; Hennessy, B. T.; Bieche, I.; Saal, L. H.; Stal, O.; Iacopetta, B.; Jensen, J. D.; O'Toole, S.; Lopez-Knowles, E.; Barbaraeschi, M.; Noguchi, S.; Azim, H. A., Jr.; Lerma, E.; Bachelot, T.; Wang, Q.; Perez-Tenorio, G.; Can de Velde, C. J. H.; Rea, D. W.; Sabine, V.; Bartlett, J. M. S.; Sotiriou, C.; Michiels, S.; Loi, S.
JOURNAL OF CLINICAL ONCOLOGY 36(10):981-990, 2018
Could the properties of IL-27 make it an ideal adjuvant for anticancer immunotherapy?
Swarbrick, A.; Junankar, S. R.; Batten, M.;
Oncoimmunology 2(8):e25409, 2013
The Hedgehog signalling pathway as a therapeutic target in early breast cancer development
O'Toole, S.A.; Swarbrick, A.; Sutherland, R.L.
EXPERT OPINION ON THERAPEUTIC TARGETS 13(9):1095-1103, 2009
FISH analysis of selected soft tissue tumors: Diagnostic experience in a tertiary center
Vargas, A. C.; Selinger, C.; Satgunaseelan, L.; Cooper, W. A.; Gupta, R.; Stalley, P.; Brown, W.; Soper, J.; Schatz, J.; Boyle, R.; Thomas, D. M.; Tattersall, M. H. N.; Bhadri, V.; Maclean, F.; Bonar, S. F.; Scolyer, R. A.; Karim, R. Z.; McCarthy, S. W.; Mahar, A.; O'Toole, S. A.
Asia-Pacific Journal of Clinical Oncology 15(1):38-47, 2019
New insights into the role of ID proteins in breast cancer metastasis: a MET affair
Teo, W. S.; Nair, R.; Swarbrick, A.
BREAST CANCER RESEARCH 16(2):305, 2014
Toll-like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2
Liu, Y. D.; Yu, L.; Ying, L.; Balic, J.; Gao, H.; Deng, N. T.; West, A.; Yan, F.; Ji, C. B.; Gough, D.; Tan, P.; Jenkins, B. J.; Li, J. K.
INTERNATIONAL JOURNAL OF CANCER 144(12):3056-3069, 2019
Cell cycle marker expression in benign and malignant intraductal papillary lesions of the breast
Loh, S. F.
; Cooper, C.
; Selinger, C. I.
; Barnes, E. H.
; Chan, C.
; Carmalt, H.
; West, R.
; Gluch, L.
; Beith, J. M.
; Caldon, C. E.
; O'Toole, S.;
JOURNAL OF CLINICAL PATHOLOGY 68(3):187-191, 2015
mtDNA heteroplasmy level and copy number indicate disease burden in m.3243A > G mitochondrial disease
Grady, J. P.; Pickett, S. J.; Ng, Y. S.; Alston, C. L.; Blakely, E. L.; Hardy, S. A.; Feeney, C. L.; Bright, A. A.; Schaefer, A. M.; Gorman, G. S.; McNally, R. J. Q.; Taylor, R. W.; Turnbull, D. M.; McFarland, R.
EMBO Molecular Medicine 10(6) 2018
The atypical kinase RIOK1 promotes tumor growth and invasive behavior
Weinberg, F.; Reischmann, N.; Fauth, L.; Taromi, S.; Mastroianni, J.; Kohler, M.; Halbach, S.; Becker, A. C.; Deng, N.; Schmitz, T.; Uhl, F. M.; Herbener, N.; Riedel, B.; Beier, F.; Swarbrick, A.; Lassmann, S.; Dengjel, J.; Zeiser, R.; Brummer, T.
EBioMedicine 20:79-97, 2017
Discovering cancer vulnerabilities using high-throughput micro-RNA screening
Nikolic, I.; Elsworth, B.; Dodson, E.; Wu, S. Z.; Gould, C. M.; Mestdagh, P.; Marshall, G. M.; Horvath, L. G.; Simpson, K. J.; Swarbrick, A.
NUCLEIC ACIDS RESEARCH 45(22):12657-12670, 2017
The magnitude of androgen receptor positivity in breast cancer is critical for reliable prediction of disease outcome
Ricciardelli, C.; Bianco-Miotto, T.; Jindal, S.; Butler, L. M.; Leung, S.; McNeil, C. M.; O'Toole, S. A.; Ebrahimie, E.; Millar, E. K. A.; Sakko, A. J.; Ruiz, A. I.; Vowler, S. L.; Huntsman, D. G.; Birrell, S. N.; Sutherland, R. L.; Palmieri, C.; Hickey, T. E.; Tilley, W. D.
CLINICAL CANCER RESEARCH 24(10):2328-2341, 2018