Institute of Molecular Medicine, Hospital de Santa Maria
The Oncology Division at Hospital de Santa Maria has focused on bone metastases since 1995 and has been involved in 12 clinical trials (breast, colon, prostate cancer and other solid tumours, and bone metastases), and is currently active in 17 international clinical studies.
Research focuses on the role of collagen fragments as growth/survival factors for cancer cells and the hypothesis that matrix metalloproteases have a central role in bone metastasis progression and resistance to bisphosphonates. Since 2007 the Division has developed a program of biobanking bone metastases, with serum and urine samples from the same patients. The Division has also been involved in the discovery of bone metastasis gene signatures in human samples and participated in phase 2 and phase 3 trials with new bone-target agents to treat bone metastases.