The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis
The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extrinsic factors of the tumour stroma, such as the ECM and ECM remodelling; together determine the fate and behaviour of cancer cells. As a consequence, tumour progression, metastatic spread and response to therapy are ultimately controlled by ECM-driven fine-tuning of intracellular kinase signalling. The ability to target and uncouple this interaction presents an emerging and promising potential in the treatment of cancer.
|ISBN||1933-6926 (Electronic) 1933-6918 (Linking)|
|Authors||Skhinas, J. N.; Cox, T. R.|
|Responsible Garvan Author|
|Publisher Name||Cell Adhesion & Migration|
|Published Date||2017-12-29 00:00:00|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/29168660|