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Pseudoprogression Associated with Clinical Deterioration and Worsening Quality of Life in Malignant Pleural Mesothelioma

Abstract

Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related malignancy with limited treatment options. Immune checkpoint inhibition has demonstrated promising activity in MPM with the use of single-agent pembrolizumab in a mostly chemotherapy-resistant population.1 Here we report significant responses to pembrolizumab after pseudoprogression in two patients with MPM and corresponding patient-reported outcomes (PROs) related to quality of life.

Type Journal
ISBN 1556-1380 (Electronic) 1556-0864 (Linking)
Authors Barnet, M. B.; Zielinski, R. R.; Warby, A.; Lewis, C. R.; Kao, S.
Responsible Garvan Author Megan Barnet
Publisher Name Journal of Thoracic Oncology
Published Date 2018-01-01 00:00:00
Published Volume 12
Published Issue 12
Published Pages e1-e2
Status ePublication
DOI 10.1016/j.jtho.2017.09.001
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/28919393