CIRCA is a national, Garvan-led collaboration of medical and scientific professionals that investigates the genetic causes of rare immune diseases.
Our mission is to understand the genetic causes of immunological diseases in individual patients. We then use these findings to help improve outcomes for the patient, their families and other individuals with similar immune diseases.
Through CIRCA, we work closely with other scientists and health professionals to accelerate the discovery and diagnosis of rare diseases.
The CIRCA program has already transformed the lives of over 30 patients (many of whom are children).
Our key aims
- To use state-of-the-art genetics and genomics to understand the cause of disease in patients with rare or novel gene mutations;
- To understand the impact of unknown genetic variations, to improve our understanding of the immune system. This will allow for improved treatment of both the rare diseases underpinned by these genetic variations, as well as common immunological diseases in which the same pathways may be active.
Read more about our research and diagnostic process.
CIRCA partners are affiliated with:
- The Garvan Institute of Medical Research
- The Children’s Hospital at Westmead
- Sydney Children’s Hospital Randwick
- Royal Prince Alfred Hospital
- Liverpool Hospital
- St Vincent’s Hospital Sydney
- St Vincent’s Centre for Applied Medical Research
- Kirby Institute UNSW
- John Hunter Hospital Newcastle
- Sir Charles Gairdner Hospital (Perth)
- Perth Children’s Hospital
- Lady Cilento Children's Hospital (Brisbane)
- Starship Child Health (Auckland, NZ)
- The Immune Deficiencies Foundation of Australia (IDFA).
- Read the full list of members.