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A randomized phase II trial of geriatric assessment and management for older cancer patients


PURPOSE: Geriatric assessment and management (GAM) can identify current health issues and recommend interventions to optimize well-being of older adults, but no randomized trial has yet been completed in oncology. Therefore, a randomized phase 2 trial was conducted. METHODS: A two-group parallel single-blinded randomized phase II trial ( Identifier: NCT02222259) enrolled patients aged >/=70 years, diagnosed with stage 2-4 gastrointestinal, genitourinary, or breast cancer within 6 weeks of commencing chemotherapy at Princess Margaret Cancer Centre. The coprimary feasibility outcomes were the proportion of eligible patients enrolled and retained. The coprimary clinical outcomes were quality of life (QOL) (EORTC QLQ C30) and modification of cancer treatment. Descriptive and regression analyses using intent-to-treat analysis were conducted. RESULTS: Sixty-one persons (64%) agreed to participate (31 allocated to intervention arm and 30 to control group). In the control group, more participants died and refused follow-up. The benefit of intervention over control on QOL at 3 months was greater for those who survived 6 months (difference 9.28; 95% CI -10.35 to 28.91) versus those who survived only 3 months (difference 6.55; 95% CI -9.63 to 22.73). CONCLUSIONS: This trial showed that it was feasible to recruit and retain older adults for a GAM study. Those who survived at least 6 months seemed to receive a greater QOL benefit than those who died or withdrew.

Type Journal
ISBN 1433-7339 (Electronic) 0941-4355 (Linking)
Authors Puts, M. T. E.; Sattar, S.; Kulik, M.; MacDonald, M. E.; McWatters, K.; Lee, K.; Brennenstuhl, S.; Jang, R.; Amir, E.; Krzyzanowska, M. K.; Joshua, A. M.; Monette, J.; Wan-Chow-Wah, D.; Alibhai, S. M. H.
Responsible Garvan Author Prof Anthony Joshua
Published Date 2018-01-01
Published Pages doi: 10.1007/s00520-017-3820-7
Status Published in-print
DOI 10.1007/s00520-017-3820-7
URL link to publisher's version