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The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis

Abstract

The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. The interplay between the intrinsic factors of cancer cells themselves, including their genotype and signalling networks; and the extrinsic factors of the tumour stroma, such as the ECM and ECM remodelling; together determine the fate and behaviour of cancer cells. As a consequence, tumour progression, metastatic spread and response to therapy are ultimately controlled by ECM-driven fine-tuning of intracellular kinase signalling. The ability to target and uncouple this interaction presents an emerging and promising potential in the treatment of cancer.

Type Journal
ISBN 1933-6926 (Electronic) 1933-6918 (Linking)
Authors Skhinas, J. N.; Cox, T. R.
Responsible Garvan Author Dr Thomas Cox
Publisher Name Cell Adhesion & Migration
Published Date 2017-12-31
Published Pages https://doi.org/10.1080/19336918.2017.1405208
Status ePublication
DOI 10.1080/19336918.2017.1405208
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/29168660