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Effects of intracerebroventricularly administered neostigmine on sympathetic neural activities of peripheral tissues in rats


Sympathetic nervous activity (SNA) in the liver, heart, pancreas and interscapular brown adipose tissue was examined 60 min after the third cerebroventricular injection of neostigmine (5 x 10(-8) mol) in rats. We employed the technique of specific gas chromatography-mass spectrometry for simultaneous analysis of norepinephrine (NE) and its primary neuronal metabolite, 3,4-dihydroxyphenylethyleneglycol (DHPG) and used the ratio DHPG/NE as an index of SNA. Neostigmine produced significant increases in the DHPG/NE ratio in all tissues investigated. Co-administration of atropine with neostigmine completely inhibited this neostigmine-induced effect. These findings suggest that the central cholinergic-muscarinic activation with neostigmine stimulates SNA in the peripheral tissues examined.

Type Journal
ISBN 0006-8993 (Print) 0006-8993 (Linking)
Authors Gotoh, M.; Smythe, G. A.
Published Date 1991-05-01
Published Volume 548
Published Issue 1-2
Published Pages 326-8
Status Published in-print
URL link to publisher's version