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Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach

Abstract

Prediabetes affects approximately 40% of American adults. Randomized trials report that a proportion of individuals with prediabetes develop diabetes despite caloric restriction, physical activity, and/or when treated with metformin, the first-line medication for patients with type 2 diabetes mellitus (T2DM). Currently, there are no valid predictors of the effectiveness of these measures in determining who will and who will not progress to the T2DM state. Few studies have examined the clinical and phenotypic predictors of better and worse glycemic response to lifestyle interventions and metformin in prediabetes and diabetes. Further studies incorporating 'omic' approaches to discover novel markers of phenotypes and treatment effectiveness may pave the way to personalizing the treatment of prediabetes and diabetes.

Type Journal
ISBN 1879-3061 (Electronic) 1043-2760 (Linking)
Authors Samocha-Bonet, D.; Debs, S.; Greenfield, J. R.
Responsible Garvan Author Dr Dorit Samocha-Bonet
Publisher Name TRENDS IN ENDOCRINOLOGY AND METABOLISM
Published Date 2018-04-14
Published Pages pii: S1043-2760(18)30059-6
Status Always Electronic
DOI 10.1016/j.tem.2018.03.014
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/29665986
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/14532