TCR tuning of T cell subsets
After selection in the thymus, the post-thymic T cell compartments comprise heterogenous subsets of naive and memory T cells that make continuous T cell receptor (TCR) contact with self-ligands bound to major histocompatibility complex (MHC) molecules. T cell recognition of self-MHC ligands elicits covert TCR signaling and is particularly important for controlling survival of naive T cells. Such tonic TCR signaling is tightly controlled and maintains the cells in a quiescent state to avoid autoimmunity. Here, we review how naive and memory T cells are differentially tuned and wired for TCR sensitivity to self and foreign ligands.
|ISBN||1600-065X (Electronic) 0105-2896 (Linking)|
|Authors||Cho, J. H.; Sprent, J.|
|Responsible Garvan Author|
|Publisher Name||IMMUNOLOGICAL REVIEWS|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/29664578|