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TCR tuning of T cell subsets


After selection in the thymus, the post-thymic T cell compartments comprise heterogenous subsets of naive and memory T cells that make continuous T cell receptor (TCR) contact with self-ligands bound to major histocompatibility complex (MHC) molecules. T cell recognition of self-MHC ligands elicits covert TCR signaling and is particularly important for controlling survival of naive T cells. Such tonic TCR signaling is tightly controlled and maintains the cells in a quiescent state to avoid autoimmunity. Here, we review how naive and memory T cells are differentially tuned and wired for TCR sensitivity to self and foreign ligands.

Type Journal
ISBN 1600-065X (Electronic) 0105-2896 (Linking)
Authors Cho, J. H.; Sprent, J.
Responsible Garvan Author Prof Jonathan Sprent
Published Date 2018-05-01
Published Volume 283
Published Issue 1
Published Pages 129-137
Status Always Electronic
DOI 10.1111/imr.12646
URL link to publisher's version