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B cells race the clock to get a second wind

Abstract

Co-stimulatory second signals delivered through TLRs or CD40 rescue antigen-stimulated B cells from metabolic dysfunction and apoptosis. This identifies a critical time-limited window during which B cells integrate sequential signals to successfully initiate humoral immunity.

Type Journal
ISBN 1529-2916 (Electronic) 1529-2908 (Linking)
Authors Phan, T. G.; Tangye, S. G.
Responsible Garvan Author Prof Stuart Tangye
Publisher Name NATURE IMMUNOLOGY
Published Date 2018-07-09
Published Volume 19
Published Pages 791-793
Status Published in-print
DOI 10.1038/s41590-018-0166-3
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/29988092