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Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure


Cocaine- and amphetamine-regulated transcript (CART) is widely expressed in the hypothalamus and an important regulator of energy homeostasis; however, the specific contributions of different CART neuronal populations to this process are not known. Here, we show that depolarization of mouse arcuate nucleus (Arc) CART neurons via DREADD technology decreases energy expenditure and physical activity, while it exerts the opposite effects in CART neurons in the lateral hypothalamus (LHA). Importantly, when stimulating these neuronal populations in the absence of CART, the effects were attenuated. In contrast, while activation of CART neurons in the LHA stimulated feeding in the presence of CART, endogenous CART inhibited food intake in response to Arc CART neuron activation. Taken together, these results demonstrate anorexigenic but anabolic effects of CART upon Arc neuron activation, and orexigenic but catabolic effects upon LHA-neuron activation, highlighting the complex and nuclei-specific functions of CART in controlling feeding and energy homeostasis.

Type Journal
ISBN 2050-084X (Electronic) 2050-084X (Linking)
Authors Farzi, A.; Lau, J.; Ip, C. K.; Qi, Y.; Shi, Y. C.; Zhang, L.; Tasan, R.; Sperk, G.; Herzog, H.
Responsible Garvan Author Prof Herbert Herzog
Publisher Name eLife
Published Date 2018-08-21
Published Volume 7
Published Issue 7
Published Pages e36494
Status Always Electronic
DOI 10.7554/eLife.36494
URL link to publisher's version