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Single Cell RNA Sequencing of Rare Immune Cell Populations


Single-cell RNA sequencing (scRNA-Seq) is transforming our ability to characterize cells, particularly rare cells that are often overlooked in bulk population analytical approaches. This has lead to the discovery of new cell types and cellular states that echo the underlying heterogeneity and plasticity in the immune system. Technologies for the capture, sequencing, and bioinformatic analysis of single cells are rapidly improving, and scRNA-Seq is now becoming much more accessible to non-specialized laboratories. Here, we describe our experiences in adopting scRNA-Seq to the study of rare immune cells in their microanatomical niches.

Type Journal
ISBN 1664-3224 (Print) 1664-3224 (Linking)
Authors Nguyen, A.; Khoo, W. H.; Moran, I.; Croucher, P. I.; Phan, T. G.
Responsible Garvan Author Prof Tri Phan
Publisher Name Frontiers in Immunology
Published Date 2018-07-04
Published Volume 9
Published Pages 1553
Status Always Electronic
DOI 10.3389/fimmu.2018.01553
URL link to publisher's version