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Sex-difference in bone architecture and bone fragility in Vietnamese


This study sought to define the sex-difference in trabecular and cortical bone parameters in Vietnamese individuals. The study involved 1404 women and 864 men aged between 20 and 86 years who were recruited from Ho Chi Minh City, Vietnam. Trabecular and cortical volumetric BMD were measured at the proximal tibia and proximal radius at 4%, 38%, and 66% points, using a peripheral quantitative computed tomography XCT2000 (Stratec, Germany). Polar strength strain index was estimated from cortical bone parameters. Changes in bone parameters were assessed by the multiple linear regression model. Among individuals aged 20-39 years, women had significantly lower peak trabecular BMD at both the radius (40%) and tibia (16%) than men, but the age-related reduction in trabecular BMD were similar between two sexes. For cortical BMD, peak values in women and men were comparable, but the age-related diminution was greater in women than men. At any age, polar strength strain index in women was lower than men, and the difference was mainly attributable to cortical bone area and total bone mass. We conclude that in the elderly, sex-related difference in trabecular BMD is originated during growth, but sex-related difference in cortical BMD is determined by differential age-related bone loss.

Type Journal
ISBN 2045-2322 (Electronic) 2045-2322 (Linking)
Authors Ho-Pham, L. T.; Ho-Le, T. P.; Mai, L. D.; Do, T. M.; Doan, M. C.; Nguyen, T. V.
Responsible Garvan Author (missing name)
Publisher Name Scientific Reports
Published Date 2018-05-16
Published Volume 8
Published Issue 1
Published Pages 7707
Status Always Electronic
DOI 10.1038/s41598-018-26053-9
URL link to publisher's version