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Tumor endothelial marker 8 promotes cancer progression and metastasis

Abstract

Every year more than 8 million people suffer from cancer-related deaths worldwide [1]. Metastasis, the spread of cancer to distant sites, accounts for 90% of these deaths. A promising target for blocking tumor progression, without causing severe side effects [2], is Tumor Endothelial Marker 8 (TEM8), an integrin-like cell surface protein expressed predominantly in the tumor endothelium and in cancer cells [3, 4]. Here, we have investigated the role of TEM8 in cancer progression, angiogenesis and metastasis in invasive breast cancer, and validated the main findings and important results in colorectal cancer. We show that the loss of TEM8 in cancer cells results in inhibition of cancer progression, reduction in tumor angiogenesis and reduced metastatic burden in breast cancer mouse models. Furthermore, we show that TEM8 regulates cancer progression by affecting the expression levels of cell cycle-related genes. Taken together, our findings may have broad clinical and therapeutic potential for breast and colorectal primary tumor and metastasis treatment by targeting TEM8.

Type Journal
ISBN 1949-2553
Authors Hoye, A. M.; Tolstrup, S. D.; Horton, E. R.; Nicolau, M.; Frost, H.; Woo, J. H.; Mauldin, J. P.; Frankel, A. E.; Cox, T. R.; Erler, J. T.
Responsible Garvan Author Dr Thomas Cox
Publisher Name Oncotarget
Published Date 2018-07-10
Published Volume 9
Published Issue 53
Published Pages 30173-30188
Status Published in-print
DOI 10.18632/oncotarget.25734
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/?term=PMC6059023
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/14654