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Provenance and risk in transfer of biological materials


Whereas biological materials were once transferred freely, there has been a marked shift in the formalisation of exchanges involving these materials, primarily through the use of Material Transfer Agreements (MTAs). This paper considers how risk aversion dominates MTA negotiations and the impact it may have on scientific progress. Risk aversion is often based on unwarranted fears of incurring liability through the use of a material or loss of control or missing out on commercialisation opportunities. Evidence to date has suggested that complexity tends to permeate even straightforward transactions despite extensive efforts to implement simple, standard MTAs. We argue that in most cases, MTAs need do little more than establish provenance, and any attempt to extend MTAs beyond this simple function constitutes stifling behaviour. Drawing on available examples of favourable practice, we point to a number of strategies that may usefully be employed to reduce risk-averse tendencies, including the promotion of simplicity, education of those engaged in the MTA process, and achieving a cultural shift in the way in which technology transfer office (TTO) success is measured in institutions employing MTAs.

Type Journal
ISBN 1544-9173
Authors Nielsen, J.; Bubela, T.; Chalmers, D. R. C.; Johns, A.; Kahl, L.; Kamens, J.; Lawson, C.; Liddicoat, J.; McWhirter, R.; Monotti, A.; Scheibner, J.; Whitton, T.; Nicol, D.
Responsible Garvan Author Amber Johns
Publisher Name PLOS BIOLOGY
Published Date 2018-08-13
Published Volume 16
Published Issue 8
Published Pages e2006031
Status Always Electronic
DOI 10.1371/journal.pbio.2006031
OpenAccess link to author's accepted manuscript version