Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: Preliminary findings


Translation of radiomics into the clinic may require a more comprehensive understanding of the underlying morphologic tissue characteristics they reflect. In the context of prostate cancer (PCa), some studies have correlated gross histological measurements of gland lumen, epithelium, and nuclei with disease appearance on MRI. Quantitative histomorphometry (QH), like radiomics for radiologic images, is the computer based extraction of features for describing tumor morphology on digitized tissue images. In this work, we attempt to establish the histomorphometric basis for radiomic features for prostate cancer by (1) identifying the radiomic features from T2w MRI most discriminating of low vs. intermediate/high Gleason score, (2) identifying QH features correlated with the most discriminating radiomic features previously identified, and (3) evaluating the discriminative ability of QH features found to be correlated with spatially co-localized radiomic features. On a cohort of 36 patients (23 for training, 13 for validation), Gabor texture features were identified as being most predictive of Gleason grade on MRI (AUC of 0.69) and gland lumen shape features were identified as the most predictive QH features (AUC = 0.75). Our results suggest that the PCa grade discriminability of Gabor features is a consequence of variations in gland shape and morphology at the tissue level.

Type Journal
ISBN 1932-6203
Authors Penzias, G.; Singanamalli, A.; Elliott, R.; Gollamudi, J.; Shih, N.; Feldman, M.; Stricker, P. D.; Delprado, W.; Tiwari, S.; Bohm, M.; Haynes, A. M.; Ponsky, L.; Fu, P.; Tiwari, P.; Viswanath, S.; Madabhushi, A.
Responsible Garvan Author Anne-Maree Haynes
Publisher Name PLoS One
Published Date 2018-08-31
Published Volume 13
Published Issue 8
Published Pages e0200730
Status Always Electronic
DOI 10.1371/journal.pone.0200730
URL link to publisher's version
OpenAccess link to author's accepted manuscript version