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Emerging data and future directions for CDK4/6 inhibitor treatment of patients with hormone receptor positive HER2-non-amplified metastatic breast cancer


Cyclin-dependent kinase (CDK4/6) inhibitors in combination with endocrine therapy are currently the optimal first line treatment for hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) non-amplified metastatic breast cancer (MBC). However, not all patients benefit from this treatment and all patients will inevitably progress. Identifying therapeutic strategies in this setting is therefore of immediate clinical importance. We present an overview of the mechanisms of resistance to CDK4/6 inhibitors and review potential biomarkers that may guide therapy selection. We also discuss the use of CDK4/6 inhibitors in the context of non-HR-positive/HER2-non-amplified breast cancer and in combination with therapies other than endocrine therapy.

Type Journal
ISBN 1743-7555
Authors Lim, E.; Beith, J.; Boyle, F.; de Boer, R.; Hui, R.; McCarthy, N.; Redfern, A.; Wade, T.; Woodward, N.
Responsible Garvan Author Prof Elgene Lim
Publisher Name Asia-Pacific Journal of Clinical Oncology
Published Date 2018-10-01
Published Volume 14 Suppl 4
Published Pages 12-21
Status Published in-print
DOI 10.1111/ajco.13065